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Huang et al., 2022 - Google Patents

Decreased spliceosome fidelity inhibits mTOR signalling and promotes longevity via an intron retention event

Huang et al., 2022

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Document ID
12332139745035786095
Author
Huang W
Kew C
Fernandes S
Loerhke A
Han L
Demetriades C
Antebi A
Publication year
Publication venue
bioRxiv

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Snippet

Abstract Changes in splicing fidelity are associated with loss of homeostasis and ageing–, yet only a handful of splicing factors have been shown to be causally required to promote longevity–, and the underlying mechanisms and downstream targets in these paradigms …
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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