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Rodrı́guez et al., 2004 - Google Patents

First total synthesis of 7 (S), 16 (R), 17 (S)-Resolvin D2, a potent anti-inflammatory lipid mediator

Rodrı́guez et al., 2004

Document ID
1142164033281230055
Author
Rodrı́guez A
Spur B
Publication year
Publication venue
Tetrahedron letters

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The first total synthesis of 7 (S), 16 (R), 17 (S)-Resolvin D2, a lipid mediator derived from docosahexaenoic acid, has been achieved. The key features of our synthetic strategy encompass a Co-salen hydrolytic kinetic resolution of a terminal epoxide combined with a …
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    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
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