Elder, 1997 - Google Patents
The immunologic target: antigenic aspects of basement membranesElder, 1997
- Document ID
- 11020819761322311374
- Author
- Elder M
- Publication year
- Publication venue
- Developments in Ophthalmology
External Links
Snippet
It is postulated that ocular cicatricial pemphigoid (OCP) is triggered by blood-borne antibodies that bind to naturally occurring antigens within the basement membrane zone (BMZ) of skin and mucous membranes. Similar mechanisms exist for bullous skin diseases …
- 210000002469 Basement Membrane 0 title abstract description 40
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Chew et al. | Basement membrane defects in genetic kidney diseases | |
| Kashtan et al. | Distribution of the α1 and α2 chains of collagen IV and of collagens V and VI in Alport syndrome | |
| Denda et al. | Identification of osteopontin as a novel ligand for the integrin α8β1 and potential roles for this integrin–ligand interaction in kidney morphogenesis | |
| Kashtan et al. | Abnormal glomerular basement membrane laminins in murine, canine, and human Alport syndrome: Aberrant laminin α2 deposition is species independent | |
| KR101581733B1 (en) | Antibodies specific for the protofibril form of beta-amyloid protein | |
| Mayne et al. | Collagens of cartilage | |
| JP4863548B2 (en) | Method of detecting, preventing and treating renal injury by modulation, regulation and inhibition of connective tissue growth factor | |
| JP2002512038A (en) | Methods for inhibiting tumor invasion or spread in a subject | |
| Smaniotto et al. | Growth hormone modulates thymocyte development in vivo through a combined action of laminin and CXC chemokine ligand 12 | |
| Fox et al. | Pathogenesis and treatment of Sjögren's syndrome | |
| JP2013126418A (en) | Use of a33 antigen and jam-it | |
| JPH05503070A (en) | A method for inhibiting lymphocyte adhesion to vascular endothelium using a novel extracellular matrix receptor/ligand interaction | |
| RU2770006C2 (en) | Ix padua factor antibodies | |
| JP3497133B2 (en) | A-33 related antigens and their pharmacological uses | |
| Yard et al. | Decreased glomerular expression of agrin in diabetic nephropathy and podocytes, cultured in high glucose medium | |
| EP1977234B1 (en) | Type V collagen for use in a method of treatment of idiopathic pulmonary fibrosis | |
| Enders et al. | Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: α3 (IV) collagen chain expressed at the initiation of spermatogenesis | |
| JP2006501862A5 (en) | ||
| JP2007524605A (en) | Inhibitors of integrin α5β1 and their use for control of tissue granulation | |
| WO1995017673A1 (en) | Ocular diagnostics and therapies | |
| Magner et al. | Aberrant development of thymocytes in mice lacking laminin‐2 | |
| JP2004514649A (en) | Therapeutic approaches to diseases by suppressing nuclear transcription factors of the NURR subfamily | |
| Beaulieu et al. | Expression of the α-5 (IV) collagen chain in the fetal human small intestine | |
| Chai et al. | TGF-β1 induces aberrant laminin chain and collagen type IV isotype expression in the glomerular basement membrane | |
| US20020076799A1 (en) | Compositions and methods for modulating TGF-beta signaling |