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Thompson et al., 1998 - Google Patents

Animal models for studying the action of topoisomerase I targeted drugs

Thompson et al., 1998

Document ID
8318252092899698823
Author
Thompson J
Stewart C
Houghton P
Publication year
Publication venue
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression

External Links

Snippet

Almost 30 years after the unsuccessful clinical evaluation of camptothecin sodium, there has been a revival in interest in this class of agent that poisons topoisomerase I. Currently there are four camptothecin analogues in clinical trials each at different levels of advancement …
Continue reading at www.sciencedirect.com (other versions)

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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