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Fischer et al., 1986 - Google Patents

Protein-Chemical Identification of the Major Cleavage Sites of the Ca 2⊕ Proteinase on Murine Vimentin, the Mesenchymal Intermediate Filament Protein

Fischer et al., 1986

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Document ID
7371854895093512570
Author
Fischer S
Vandekerckhove J
Ampe C
Traub P
Weber K
Publication year

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Neutral thiol proteinases (calpains), activated by calcium are involved in the intracellular turnover of intermediate filaments but the precise position of the cleavage points has remained unkown. Here we identify by direct sequence analysis the major cleavage sites …
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
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    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
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    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
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