Tian et al., 2023 - Google Patents
BMSCs overexpressing hBcl2 can resist myelin-induced apoptosis and promote repair after spinal cord injury in ratsTian et al., 2023
View PDF- Document ID
- 5737237784918459515
- Author
- Tian D
- You X
- Ye J
- Chen G
- Yu H
- Lv J
- Shan F
- Liang C
- Bi Y
- Zheng M
- et al.
- Publication year
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Snippet
After spinal cord injury (SCI), the production of myelin debris at the lesion core worsens parenchymal cell death and hinders axonal regrowth. BMSCs are susceptible to apoptosis after transplantation, and it remains unclear if this process is associated with myelin debris …
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- A—HUMAN NECESSITIES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
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