Solitary pulmonary nodule (SPN) is a frequent finding on the chest x-ray and computed tomography.... more Solitary pulmonary nodule (SPN) is a frequent finding on the chest x-ray and computed tomography. Nuclear medicine techniques play an important role in the diagnosis and management of SPN. In the current review, we briefly will explain the different nuclear medicine modalities in this regard including positron emission tomography (PET) using 18-F-FDG, and 11-C-Methionine, and single photon emission computerized tomography (SPECT) using somatostatin receptor scintigraphy, 201-Thallium, and 99m-Tc-MIBI.
A recent publication by Mourato et al. on somatostatin receptor (SSTR) PET/CT and its comparison ... more A recent publication by Mourato et al. on somatostatin receptor (SSTR) PET/CT and its comparison with FDG PET/CT in patients with differentiated thyroid cancer (DTC) [1] along with some other recent studies [2, 4–6] intrigued us to prepare a short update review on SSTR application in diagnostic imaging and therapy of DTC patients (Table 1). An important challenge for SSTR PET/CT to be used as a diagnostic tool in DTC patients is finding the best cutoff value for thyroglobulin (Tg) level. Mourato et al. noted that due to lack of enough literature addressing the best cutoff value, it was not feasible to perform a meta-regression. Providing both stimulated and non-stimulated Tg cutoffs might be of interest for endocrinologists, while the former may add marginal benefit for detecting the lesions [7, 8]. Again, this is an issue where more research and publications may add more evidence to what is available. Another challenge is gathering enough evidence to decide whether peptide receptor radionuclide therapy (PRRT) is effective by finding a sufficient number of suitable candidates. Our nuclear medicine center with the experience of more than 3000 DTC cases has only had 41 suitable candidates for SSTR SPECT/CT so far. We have recently presented some of our findings in the SSTR subgroup. Most of these candidates were women (71.4%), mainly either stage I or IV (34.3% for each) iodine-refractory DTCs (88.2% papillary, 11.8% follicular), with mean Tg levels of 154 ng/ mL at the time of their SSTR scintigraphy. These patients were significantly older as compared to the whole dataset (41.5 ± 14.7 years for the entire cohort vs. 54.8 ± 15.6 years for patients undergoing SSTR scintigraphy). Even so, only half of these candidate patients (mainly the younger ones) showed considerable SSTR uptake (45.7% Krenning score III, 5.7% Krenning score IV) [3]. It is of value to note that there are limited published results on the value of PRRT in patients with sufficient SSTR uptake [4]. While some novel radiotracers such as those labeled with integrins and borate are in the pipeline for imaging of DTC patients [9, 10], it is our duty as nuclear medicine specialists to better elucidate how and when to use nuclear medicine imaging modalities. Mourato et al. have beautifully completed this task [1].
ABSTRACT A patient with multiple endocrine neoplasia type 2A syndrome who had exhausted several s... more ABSTRACT A patient with multiple endocrine neoplasia type 2A syndrome who had exhausted several surgeries and radiotherapy was referred to nuclear medicine department for theranostic approaches. [68Ga]-DOTATATE PET/CT and [131I]I-mIBG SPECT/CT were performed, but the degree of uptake was insufficient for using the treatment companion of these tracers. Finally, 1 year later, [68Ga]-FAPI-46 PET/CT showed progressive disease with metastases to the lung, liver, bone, and lymph nodes with intense [68Ga]-FAPI-46 uptake. Treatment with [177Lu]Lu-FAPI-46 was done, and the patient tolerated treatment and showed evidence of clinical improvement following therapy.
Article type Systematic review article Introduction: This systematic review studies the prognosti... more Article type Systematic review article Introduction: This systematic review studies the prognostic value of two conventional imaging tools, sestamibi and gallium scans, for predicting how patients with Hodgkin lymphoma will respond to treatment. Methods: The PubMed database was searched for English-language articles that contained the following search terms: (Hodgkin AND (mibi OR sestamibi OR gallium OR spect) AND response). All articles that were identified during this search were included in the study, regardless of date published. The inclusion criteria were as follows: articles that described studies that were limited to Hodgkin patients and that reported the predictive value of conventional imaging tools. Articles about other types of lymphoma and/or those that focused on the diagnostic and staging accuracy of mibi and gallium scans were excluded. Result: In total, 14 articles were retrieved. Of these, the majority met the inclusion criteria of the systematic review with the ex...
SummaryAim: Hip prosthesis implantation has witnessed a significant increase in recent years. Des... more SummaryAim: Hip prosthesis implantation has witnessed a significant increase in recent years. Despite the advantages of this surgical procedure, it has some complications, the most serious of which is prosthetic infection. This study was conducted to investigate the feasibility of 99mTc-UBI scintigraphy in detection of infectious foci in painful hip prosthesis. UBI (Ubiquicidin 29–41) is an antimicrobial peptide fragment with the ability to target the bacterial colony directly. Patients, methods: 34 patients, aged 20–79 years, with painful hip prosthesis were included. 99mTc-UBI scan and three phase bone scan were performed and two nuclear medicine specialists interpreted the UBI scans with and without bone scan results at hand. Both qualitative and semiquantitative methods were used to interpret the 30 minute post injection images. The patients were actively followed up. According to the surgical findings, microbiological culture and active follow up, final diagnosis was made. Resu...
To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel ... more To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel node mapping in breast carcinoma. Fifty patients with early-stage breast cancer were included in our study. 17.5 MBq Tc-99m-MIBI was injected intradermally to 25 patients and the remainders were injected with the same dose of Tc-99m-antimony sulphide colloid. Anterior and lateral static images were taken at 2 minutes. If sentinel lymph node was not detected, delayed imaging by up to 180 minutes was carried out. The patients were operated on 2-4 hours post-injection. Sentinel lymph node biopsy was performed by the aid of gamma probe and blue dye during surgery. In the Tc-99m-MIBI group, 23 patients had lymph nodes on scintigraphy images, and sentinel nodes were detected during surgery in all 23 patients. In the Tc-99m-antimony sulphide colloid group, 24 patients had lymph nodes on scintigraphy images, and sentinel nodes were identified during surgery in 24 patients. We concluded that 99mT...
Introduction: Sentinel lymph node biopsy is the standard procedure for lymph node staging in inte... more Introduction: Sentinel lymph node biopsy is the standard procedure for lymph node staging in intermediate thickness melanoma. In Iran, this procedure has not been addressed sufficiently. In this study, we report our experience in this area. Methods: Ten consecutive patients with intermediate thickness melanoma where included in our study. 1.5 mCi of Tc-99m antimony sulfide colloid in two divided dose was injected around the tumor. All patients underwent surgery 2-4 hours after injection of the tracer. Patent blue V dye was also used for 8 patients. Using a hand-held gamma probe, the sentinel nodes were harvested and sent to the pathologist for frozen section and H&E review. For patients with positive sentinel nodes, lymph node dissection was performed. Results: At least one sentinel node could be harvested in all patients. The mean number of sentinel nodes was 1.66. Detection rate with radiotracer and blue dye was 100% and 75% respectively. 30% of the patients had positive sentinel ...
Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein, which is anchored i... more Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein, which is anchored in the cell membrane of prostate epithelial cells. It is highly expressed on prostate epithelial cells and strongly up-regulated in prostate cancer. Although, 177Lu-PSMA has been recently introduced for radionuclide therapy of metastatic castration-resistant prostate cancer (mCRPC) with continuously increasing interest and use worldwide. This guideline is intended to assist nuclear medicine physicians in evaluating and managing patients with mRCPC for whom radioligand therapy (RLT) using 177Lu-PSMA is a promising treatment option. In addition, more information could be provided by subsequent investigative studies in the field of RLT.
Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with diffe... more Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. MDS is one of the serious complications of AA. Karyotyping is definitive in the diagnosis of MDS. Better and robust investigations like 18F-Fluoro-deoxy-Glucose Positron Emission Tomography/Computed Tomography (18F-FDG PET-CT) are essential in high risk patients with haematological malignancies and in those relapsing within a short period of time after initiation of therapy or having refractory disease. It might be helpful in the development of individual treatment algorithms for these high-risk patients. There may be unique problems in hematological malignancies where the transformation of one pathology into another may be silent with no biomarkers that can predict this transformation e.g. transformation of MDS from AA. Studies have shown that immune suppression ca...
Nuclear medicine review. Central & Eastern Europe, 2010
BACKGROUND To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) fo... more BACKGROUND To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel node mapping in breast carcinoma. MATERIAL AND METHODS Fifty patients with early-stage breast cancer were included in our study. 17.5 MBq Tc-99m-MIBI was injected intradermally to 25 patients and the remainders were injected with the same dose of Tc-99m-antimony sulphide colloid. Anterior and lateral static images were taken at 2 minutes. If sentinel lymph node was not detected, delayed imaging by up to 180 minutes was carried out. The patients were operated on 2-4 hours post-injection. Sentinel lymph node biopsy was performed by the aid of gamma probe and blue dye during surgery. RESULTS In the Tc-99m-MIBI group, 23 patients had lymph nodes on scintigraphy images, and sentinel nodes were detected during surgery in all 23 patients. In the Tc-99m-antimony sulphide colloid group, 24 patients had lymph nodes on scintigraphy images, and sentinel nodes were identified during surger...
Nuclear medicine review. Central & Eastern Europe, 2020
Brain metastases of PTC are rare and occur in 0.1-5% of the patients, especially in the poorly di... more Brain metastases of PTC are rare and occur in 0.1-5% of the patients, especially in the poorly differentiated types that usually fail to concentrate iodine. We present a rare case of PTC with probable brain metastasis in a 58-year-old woman with a history of poorly differentiated PTC that showed elevated Tg levels and no metastasis was detected in the whole-body iodine scan, despite the positive 99m Tc-octreotide scintigraphy. This imaging modality could be helpful as a diagnostic guide for radionuclide therapy with labeled somatostatin analogs in cases of thyroid carcinoma with elevated Tg levels and negative whole-body iodine scan.
Journal of patient safety and quality improvement, 2019
Introduction: Finding optimum time of post ablation whole body iodine scan in patients with diffe... more Introduction: Finding optimum time of post ablation whole body iodine scan in patients with differentiated thyroid cancer(DTC) treated with I-131.Material and Methods: 20 patients with DTC, who were treated with I131 underwent post ablation whole body iodine scan (WBIS) in days 4, 7 and 9 after treatment. A dual head gamma camera (e-cam, Siemens) equipped with high energy parallel hole collimator was used for imaging. The images were acquired with 7cm/min and stored in a 1024 ×256 matrix. Results: 3 Patients had negative WBIS in all three sets of imaging and 17 patients had postsurgical thyroid remnants on all 3 scans. On days 4 and 7 we detected 11 patients with cervical lymph node metastases while on day 9 only 9 patients showed cervical lymph node metastases.(P=0.135)On all 3 sets of images, we encountered 4 patients with mediastinal lymph node metastases and 1 patient with bone metastasis. In addition, all 3 sets of images detected lung metastases in three patients. The total nu...
Torture : quarterly journal on rehabilitation of torture victims and prevention of torture, 2012
AIM The aim of this study is to evaluate the role of functional imaging for forensic purposes. ME... more AIM The aim of this study is to evaluate the role of functional imaging for forensic purposes. METHODS We reviewed a few outpatient cases that were sent to our department for examination after traumatic events and one case with neuropsychic disturbances. RESULTS Functional imaging showed signs of traumatic lesions in the skeletal system, of brain metabolism and of renal failure. CONCLUSION Functional disturbances following traumatic events are in some cases more important than morphological abnormalities. Targeted scintigraphic examinations could be applied for visualisation of traumatic lesions or evaluation of functional disturbances caused by traumatic events. These examinations can be used as evidence in the courtroom.
A 33-year-old female with a history of total thyroidectomy for papillary thyroid carcinoma was re... more A 33-year-old female with a history of total thyroidectomy for papillary thyroid carcinoma was referred to the nuclear medicine department for ablative radioiodine therapy. Post ablation scan showed an area of intense iodine uptake on the left side of the pelvic region, corresponding to the large well-defined heterogeneous mass in the left ovary in the SPECT/CT images. The radiologic features of this lesion were compatible with a dermoid cyst, previously unrecognized. Eventually, the lesion was laparoscopically removed, and a typical dermoid cyst was confirmed through histopathologic assessment.
Solitary pulmonary nodule (SPN) is a frequent finding on the chest x-ray and computed tomography.... more Solitary pulmonary nodule (SPN) is a frequent finding on the chest x-ray and computed tomography. Nuclear medicine techniques play an important role in the diagnosis and management of SPN. In the current review, we briefly will explain the different nuclear medicine modalities in this regard including positron emission tomography (PET) using 18-F-FDG, and 11-C-Methionine, and single photon emission computerized tomography (SPECT) using somatostatin receptor scintigraphy, 201-Thallium, and 99m-Tc-MIBI.
A recent publication by Mourato et al. on somatostatin receptor (SSTR) PET/CT and its comparison ... more A recent publication by Mourato et al. on somatostatin receptor (SSTR) PET/CT and its comparison with FDG PET/CT in patients with differentiated thyroid cancer (DTC) [1] along with some other recent studies [2, 4–6] intrigued us to prepare a short update review on SSTR application in diagnostic imaging and therapy of DTC patients (Table 1). An important challenge for SSTR PET/CT to be used as a diagnostic tool in DTC patients is finding the best cutoff value for thyroglobulin (Tg) level. Mourato et al. noted that due to lack of enough literature addressing the best cutoff value, it was not feasible to perform a meta-regression. Providing both stimulated and non-stimulated Tg cutoffs might be of interest for endocrinologists, while the former may add marginal benefit for detecting the lesions [7, 8]. Again, this is an issue where more research and publications may add more evidence to what is available. Another challenge is gathering enough evidence to decide whether peptide receptor radionuclide therapy (PRRT) is effective by finding a sufficient number of suitable candidates. Our nuclear medicine center with the experience of more than 3000 DTC cases has only had 41 suitable candidates for SSTR SPECT/CT so far. We have recently presented some of our findings in the SSTR subgroup. Most of these candidates were women (71.4%), mainly either stage I or IV (34.3% for each) iodine-refractory DTCs (88.2% papillary, 11.8% follicular), with mean Tg levels of 154 ng/ mL at the time of their SSTR scintigraphy. These patients were significantly older as compared to the whole dataset (41.5 ± 14.7 years for the entire cohort vs. 54.8 ± 15.6 years for patients undergoing SSTR scintigraphy). Even so, only half of these candidate patients (mainly the younger ones) showed considerable SSTR uptake (45.7% Krenning score III, 5.7% Krenning score IV) [3]. It is of value to note that there are limited published results on the value of PRRT in patients with sufficient SSTR uptake [4]. While some novel radiotracers such as those labeled with integrins and borate are in the pipeline for imaging of DTC patients [9, 10], it is our duty as nuclear medicine specialists to better elucidate how and when to use nuclear medicine imaging modalities. Mourato et al. have beautifully completed this task [1].
ABSTRACT A patient with multiple endocrine neoplasia type 2A syndrome who had exhausted several s... more ABSTRACT A patient with multiple endocrine neoplasia type 2A syndrome who had exhausted several surgeries and radiotherapy was referred to nuclear medicine department for theranostic approaches. [68Ga]-DOTATATE PET/CT and [131I]I-mIBG SPECT/CT were performed, but the degree of uptake was insufficient for using the treatment companion of these tracers. Finally, 1 year later, [68Ga]-FAPI-46 PET/CT showed progressive disease with metastases to the lung, liver, bone, and lymph nodes with intense [68Ga]-FAPI-46 uptake. Treatment with [177Lu]Lu-FAPI-46 was done, and the patient tolerated treatment and showed evidence of clinical improvement following therapy.
Article type Systematic review article Introduction: This systematic review studies the prognosti... more Article type Systematic review article Introduction: This systematic review studies the prognostic value of two conventional imaging tools, sestamibi and gallium scans, for predicting how patients with Hodgkin lymphoma will respond to treatment. Methods: The PubMed database was searched for English-language articles that contained the following search terms: (Hodgkin AND (mibi OR sestamibi OR gallium OR spect) AND response). All articles that were identified during this search were included in the study, regardless of date published. The inclusion criteria were as follows: articles that described studies that were limited to Hodgkin patients and that reported the predictive value of conventional imaging tools. Articles about other types of lymphoma and/or those that focused on the diagnostic and staging accuracy of mibi and gallium scans were excluded. Result: In total, 14 articles were retrieved. Of these, the majority met the inclusion criteria of the systematic review with the ex...
SummaryAim: Hip prosthesis implantation has witnessed a significant increase in recent years. Des... more SummaryAim: Hip prosthesis implantation has witnessed a significant increase in recent years. Despite the advantages of this surgical procedure, it has some complications, the most serious of which is prosthetic infection. This study was conducted to investigate the feasibility of 99mTc-UBI scintigraphy in detection of infectious foci in painful hip prosthesis. UBI (Ubiquicidin 29–41) is an antimicrobial peptide fragment with the ability to target the bacterial colony directly. Patients, methods: 34 patients, aged 20–79 years, with painful hip prosthesis were included. 99mTc-UBI scan and three phase bone scan were performed and two nuclear medicine specialists interpreted the UBI scans with and without bone scan results at hand. Both qualitative and semiquantitative methods were used to interpret the 30 minute post injection images. The patients were actively followed up. According to the surgical findings, microbiological culture and active follow up, final diagnosis was made. Resu...
To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel ... more To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel node mapping in breast carcinoma. Fifty patients with early-stage breast cancer were included in our study. 17.5 MBq Tc-99m-MIBI was injected intradermally to 25 patients and the remainders were injected with the same dose of Tc-99m-antimony sulphide colloid. Anterior and lateral static images were taken at 2 minutes. If sentinel lymph node was not detected, delayed imaging by up to 180 minutes was carried out. The patients were operated on 2-4 hours post-injection. Sentinel lymph node biopsy was performed by the aid of gamma probe and blue dye during surgery. In the Tc-99m-MIBI group, 23 patients had lymph nodes on scintigraphy images, and sentinel nodes were detected during surgery in all 23 patients. In the Tc-99m-antimony sulphide colloid group, 24 patients had lymph nodes on scintigraphy images, and sentinel nodes were identified during surgery in 24 patients. We concluded that 99mT...
Introduction: Sentinel lymph node biopsy is the standard procedure for lymph node staging in inte... more Introduction: Sentinel lymph node biopsy is the standard procedure for lymph node staging in intermediate thickness melanoma. In Iran, this procedure has not been addressed sufficiently. In this study, we report our experience in this area. Methods: Ten consecutive patients with intermediate thickness melanoma where included in our study. 1.5 mCi of Tc-99m antimony sulfide colloid in two divided dose was injected around the tumor. All patients underwent surgery 2-4 hours after injection of the tracer. Patent blue V dye was also used for 8 patients. Using a hand-held gamma probe, the sentinel nodes were harvested and sent to the pathologist for frozen section and H&E review. For patients with positive sentinel nodes, lymph node dissection was performed. Results: At least one sentinel node could be harvested in all patients. The mean number of sentinel nodes was 1.66. Detection rate with radiotracer and blue dye was 100% and 75% respectively. 30% of the patients had positive sentinel ...
Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein, which is anchored i... more Prostate-specific membrane antigen (PSMA) is a type II transmembrane protein, which is anchored in the cell membrane of prostate epithelial cells. It is highly expressed on prostate epithelial cells and strongly up-regulated in prostate cancer. Although, 177Lu-PSMA has been recently introduced for radionuclide therapy of metastatic castration-resistant prostate cancer (mCRPC) with continuously increasing interest and use worldwide. This guideline is intended to assist nuclear medicine physicians in evaluating and managing patients with mRCPC for whom radioligand therapy (RLT) using 177Lu-PSMA is a promising treatment option. In addition, more information could be provided by subsequent investigative studies in the field of RLT.
Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with diffe... more Although aplastic anemia (AA) and myelodysplastic syndrome (MDS) are separate entities with different management, distinction between the two can be difficult on morphological basis due to hypocellularity of bone marrow. MDS is one of the serious complications of AA. Karyotyping is definitive in the diagnosis of MDS. Better and robust investigations like 18F-Fluoro-deoxy-Glucose Positron Emission Tomography/Computed Tomography (18F-FDG PET-CT) are essential in high risk patients with haematological malignancies and in those relapsing within a short period of time after initiation of therapy or having refractory disease. It might be helpful in the development of individual treatment algorithms for these high-risk patients. There may be unique problems in hematological malignancies where the transformation of one pathology into another may be silent with no biomarkers that can predict this transformation e.g. transformation of MDS from AA. Studies have shown that immune suppression ca...
Nuclear medicine review. Central & Eastern Europe, 2010
BACKGROUND To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) fo... more BACKGROUND To study the value of periareolar intra-dermal injection of Tc-99m sestamibi (MIBI) for sentinel node mapping in breast carcinoma. MATERIAL AND METHODS Fifty patients with early-stage breast cancer were included in our study. 17.5 MBq Tc-99m-MIBI was injected intradermally to 25 patients and the remainders were injected with the same dose of Tc-99m-antimony sulphide colloid. Anterior and lateral static images were taken at 2 minutes. If sentinel lymph node was not detected, delayed imaging by up to 180 minutes was carried out. The patients were operated on 2-4 hours post-injection. Sentinel lymph node biopsy was performed by the aid of gamma probe and blue dye during surgery. RESULTS In the Tc-99m-MIBI group, 23 patients had lymph nodes on scintigraphy images, and sentinel nodes were detected during surgery in all 23 patients. In the Tc-99m-antimony sulphide colloid group, 24 patients had lymph nodes on scintigraphy images, and sentinel nodes were identified during surger...
Nuclear medicine review. Central & Eastern Europe, 2020
Brain metastases of PTC are rare and occur in 0.1-5% of the patients, especially in the poorly di... more Brain metastases of PTC are rare and occur in 0.1-5% of the patients, especially in the poorly differentiated types that usually fail to concentrate iodine. We present a rare case of PTC with probable brain metastasis in a 58-year-old woman with a history of poorly differentiated PTC that showed elevated Tg levels and no metastasis was detected in the whole-body iodine scan, despite the positive 99m Tc-octreotide scintigraphy. This imaging modality could be helpful as a diagnostic guide for radionuclide therapy with labeled somatostatin analogs in cases of thyroid carcinoma with elevated Tg levels and negative whole-body iodine scan.
Journal of patient safety and quality improvement, 2019
Introduction: Finding optimum time of post ablation whole body iodine scan in patients with diffe... more Introduction: Finding optimum time of post ablation whole body iodine scan in patients with differentiated thyroid cancer(DTC) treated with I-131.Material and Methods: 20 patients with DTC, who were treated with I131 underwent post ablation whole body iodine scan (WBIS) in days 4, 7 and 9 after treatment. A dual head gamma camera (e-cam, Siemens) equipped with high energy parallel hole collimator was used for imaging. The images were acquired with 7cm/min and stored in a 1024 ×256 matrix. Results: 3 Patients had negative WBIS in all three sets of imaging and 17 patients had postsurgical thyroid remnants on all 3 scans. On days 4 and 7 we detected 11 patients with cervical lymph node metastases while on day 9 only 9 patients showed cervical lymph node metastases.(P=0.135)On all 3 sets of images, we encountered 4 patients with mediastinal lymph node metastases and 1 patient with bone metastasis. In addition, all 3 sets of images detected lung metastases in three patients. The total nu...
Torture : quarterly journal on rehabilitation of torture victims and prevention of torture, 2012
AIM The aim of this study is to evaluate the role of functional imaging for forensic purposes. ME... more AIM The aim of this study is to evaluate the role of functional imaging for forensic purposes. METHODS We reviewed a few outpatient cases that were sent to our department for examination after traumatic events and one case with neuropsychic disturbances. RESULTS Functional imaging showed signs of traumatic lesions in the skeletal system, of brain metabolism and of renal failure. CONCLUSION Functional disturbances following traumatic events are in some cases more important than morphological abnormalities. Targeted scintigraphic examinations could be applied for visualisation of traumatic lesions or evaluation of functional disturbances caused by traumatic events. These examinations can be used as evidence in the courtroom.
A 33-year-old female with a history of total thyroidectomy for papillary thyroid carcinoma was re... more A 33-year-old female with a history of total thyroidectomy for papillary thyroid carcinoma was referred to the nuclear medicine department for ablative radioiodine therapy. Post ablation scan showed an area of intense iodine uptake on the left side of the pelvic region, corresponding to the large well-defined heterogeneous mass in the left ovary in the SPECT/CT images. The radiologic features of this lesion were compatible with a dermoid cyst, previously unrecognized. Eventually, the lesion was laparoscopically removed, and a typical dermoid cyst was confirmed through histopathologic assessment.
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