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Molecular and Cellular Pediatrics
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  1. Patent ductus arteriosus is one of the most common cardiac conditions affecting the neonates. Considering the lack of studies done on this topic in healthcare settings in Khyber Pakhtunkhwa province, this stud...

    Authors: S. Mohsin Ali Shah, Shaista Azeem Khan, Faran Sadiq, Ruba Gul, Faizan Sadiq, Misbah Ullah Khan, Muhammad Khalid Khan, Faryal Uzma, Arooj Khan and Sabir Khan
    Citation: Molecular and Cellular Pediatrics 2025 12:2
    Content type: Research Published on:

  2. Cerebral creatine deficiency disorders (CCDD) are rare diseases caused by defects in the enzymes L-arginine: glycine amidinotransferase (AGAT) or guanidinoacetate-N-methyltransferase (GAMT), which are involved...

    Authors: Christina Kaufman, Anaïs D’Andrea, Annette Hackenberg, Martin Poms, Olivier Braissant and Johannes Häberle
    Citation: Molecular and Cellular Pediatrics 2025 12:1
    Content type: Research Published on:

  3. In neonates with congenital heart disease (CHD), myocardial remodelling involves activation of inflammatory pathways. The role of hypoxemia related pathways is however unknown. This study was therefore designe...

    Authors: Nesrine Farhat, Jaime Vazquez-Jimenez, Ruth Heying and Marie-Christine Seghaye
    Citation: Molecular and Cellular Pediatrics 2024 11:14
    Content type: Research Published on:

  4. Acute liver failure (ALF) is a rare illness marked by rapid deterioration of liver function, leading to high morbidity and mortality rates, particularly in children. While steroids have been observed to correl...

    Authors: Rania M. El-Shanawany, Eman A. El-Maadawy, Hanaa A. El-Araby and Roba M. Talaat
    Citation: Molecular and Cellular Pediatrics 2024 11:13
    Content type: Research Published on:

  5. Juvenile Idiopathic Arthritis (JIA) comprises diverse chronic inflammatory conditions driven by malfunction of the immune system. The intestinal microbiota is considered a crucial environmental factor correlat...

    Authors: Lisa Budzinski, Toni Sempert, Leonie Lietz, René Maier, Gi-Ung Kang, Anne Sae Lim von Stuckrad, Carl Christoph Goetzke, Maria Roth, Aayushi Shah, Amro Abbas, Katrin Lehman, Kathleen Necke, Stefanie Bartsch, Ute Hoffmann, Mir-Farzin Mashreghi, Robert Biesen…
    Citation: Molecular and Cellular Pediatrics 2024 11:12
    Content type: Research Published on:

  6. Parental malnutrition, particularly a low-protein diet (LPD), causes oligonephropathy at birth and predisposes offspring to hypertension and chronic kidney disease later in life. The onset of adult kidney dise...

    Authors: Fabiola Diniz, Francesca Edgington-Giordano, Samir S. El-Dahr and Giovane G. Tortelote
    Citation: Molecular and Cellular Pediatrics 2024 11:11
    Content type: Research Published on:

  7. In preterm infants, IV administration of fat is less well tolerated compared to intake via the enteral route, often resulting in hypertriglyceridemia. It is therefore recommended that parenteral fat intake sho...

    Authors: Gerhard Fusch, Naomi H. Fink, Niels Rochow and Christoph Fusch
    Citation: Molecular and Cellular Pediatrics 2024 11:10
    Content type: Research Published on:

  8. In adults with Klinefelter syndrome (KS), impaired bone health with reduced bone mineral density (BMD) has been described even in the presence of testosterone replacement therapy. The aim of the present study ...

    Authors: Julia Spiekermann, Jakob Höppner, Eliena Ibnukhsein, Kathrin Sinningen, Beatrice Hanusch, Cordula Kiewert, Heide Siggelkow and Corinna Grasemann
    Citation: Molecular and Cellular Pediatrics 2024 11:9
    Content type: Research Published on:

  9. Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by loss of tolerance to nuclear antigens. The formation of autoantibodies and the deposition of immune complexes trigger infl...

    Authors: Katharina Menzel, Kateryna Novotna, Nivya Jeyakumar, Christine Wolf and Min Ae Lee-Kirsch
    Citation: Molecular and Cellular Pediatrics 2024 11:8
    Content type: Mini review Published on:

  10. The gut is an environment in which the immune system closely interacts with a vast number of foreign antigens, both inert such as food and alive, from the viral, bacterial, fungal and protozoal microbiota. Wit...

    Authors: Christopher Wichmann, Elisa Wirthgen, Carla R. Nowosad and Jan Däbritz
    Citation: Molecular and Cellular Pediatrics 2024 11:7
    Content type: Mini Review Published on:

  11. As an indigestible component of human breast milk, Human Milk Oligosaccharides (HMOs) play an important role as a substrate for the establishing microbiome of the newborn. They have further been shown to have ...

    Authors: A. Welp, E. Laser, K. Seeger, A. Haiß, K. Hanke, K. Faust, G. Stichtenoth, C. Fortmann-Grote, J. Pagel, J. Rupp, W. Göpel, M. Gembicki, JL. Scharf, A. Rody, E. Herting, C. Härtel…
    Citation: Molecular and Cellular Pediatrics 2024 11:6
    Content type: Review Published on:

  13. Highly-effective CFTR-modulator therapy with elexa-/teza-/ivacaftor (ETI) has led to improvements in pulmonary outcomes, sweat chloride, body mass index (BMI) and quality of life in people with cystic fibrosis...

    Authors: Dorit Fabricius, Tina Knieling, Noelle Zurmuehl, Leandra Makedon, Joachim Freihorst, Hanna Schmidt and Sebastian Bode
    Citation: Molecular and Cellular Pediatrics 2024 11:4
    Content type: Research Published on:

  15. Although the severity of coronavirus disease 2019 (COVID-19) tends to be lower in children, it can still lead to severe illness, particularly among those with chronic medical conditions. While remdesivir (RDV)...

    Authors: Abigail Schulz, Natalie Huynh, Margaret Heger and Mustafa Bakir
    Citation: Molecular and Cellular Pediatrics 2024 11:2
    Content type: Research Published on:

  17. Familial Mediterranean fever (FMF) is a prototypical autoinflammatory syndrome associated with phagocytic cell activation. Pyrin mutations are the genetic basis of this disease, and its expression has been sho...

    Authors: G. Varga, S. Schleifenbaum, U. Koenig, J. Waldkirch, C. Hinze, C. Kessel, W. Geluk, T. Pap, Elke Lainka, Tilmann Kallinich, D. Foell and H. Wittkowski
    Citation: Molecular and Cellular Pediatrics 2023 10:19
    Content type: Research Published on:

  19. Onasemnogene abeparvovec has been life-changing for children with spinal muscular atrophy (SMA), signifying the potential and progress occurring in gene- and cell-based therapies for rare genetic diseases. Hen...

    Authors: Michelle A. Farrar, Loudella Calotes-Castillo, Ranil De Silva, Peter Barclay, Lani Attwood, Julie Cini, Monica Ferrie and Didu S. Kariyawasam
    Citation: Molecular and Cellular Pediatrics 2023 10:17
    Content type: Review Published on:

  21. Multisystem inflammatory syndrome in children associated with COVID-19 (MIS-C) is a late complication of pediatric COVID-19, which follows weeks after the original SARS-CoV-2 infection, regardless of its sever...

    Authors: Adam Klocperk, Marketa Bloomfield, Zuzana Parackova, Ludovic Aillot, Jiri Fremuth, Lumir Sasek, Jan David, Filip Fencl, Aneta Skotnicova, Katerina Rejlova, Martin Magner, Ondrej Hrusak and Anna Sediva
    Citation: Molecular and Cellular Pediatrics 2023 10:15
    Content type: Research Published on:

  22. Differential diagnosis in children with signs of unprovoked inflammation can be challenging. In particular, differentiating systemic juvenile idiopathic arthritis (SJIA) from other diagnoses is difficult. We h...

    Authors: Dirk Foell, Melanie Saers, Carolin Park, Ninna Brix, Mia Glerup, Christoph Kessel, Helmut Wittkowski, Claas Hinze, Lillemor Berntson, Anders Fasth, Charlotte Myrup, Ellen Nordal, Marite Rygg, Henrik Hasle, Birgitte Klug Albertsen, Troels Herlin…
    Citation: Molecular and Cellular Pediatrics 2023 10:14
    Content type: Research Published on:

  23. Scientific scrutiny has proved the safety and benefits of caffeine to treat apnoea of prematurity (AOP). However, there is no consensus on the effects of this treatment on sleep, especially considering the key...

    Authors: Ana Renata Pinto de Toledo, Higor Arruda Caetano, Jovito Adiel Skupien, Carina Rodrigues Boeck, Humberto Fiori and Rosane Souza da Silva
    Citation: Molecular and Cellular Pediatrics 2023 10:13
    Content type: Review Published on:

  25. Many inborn errors of immunity (IEI) manifest with hallmarks of both immunodeficiency and immune dysregulation due to uncontrolled immune responses and impaired immune homeostasis. A subgroup of these disorder...

    Authors: Vasil Toskov and Stephan Ehl
    Citation: Molecular and Cellular Pediatrics 2023 10:11
    Content type: Review Published on:

  26. The SARS-CoV-2 pandemic has caused significant pulmonary morbidity and mortality in the adult population. Children and adolescents typically show milder symptoms; however, a relevant proportion of them report ...

    Authors: Sebastian Felix Nepomuk Bode, Anja Schwender, Monika Toth, Christine Kaeppler-Schorn, Ute Siebeneich, Joachim Freihorst, Ales Janda and Dorit Fabricius
    Citation: Molecular and Cellular Pediatrics 2023 10:10
    Content type: Research Published on:

  28. Clinical studies suggest that female sex plays a protective role in the development and progression of kidney disease. Recent experimental studies indicate that in male rats early nephron loss under ongoing ne...

    Authors: Carlos Menendez-Castro, Nada Cordasic, Fabian B. Fahlbusch, Joachim Woelfle, Karl F. Hilgers and Andrea Hartner
    Citation: Molecular and Cellular Pediatrics 2023 10:8
    Content type: Research Published on:

  29. Human milk oligosaccharides (HMOs) are important components of human milk having diverse functions in the development of infants. Randomized controlled trials (RCTs) have demonstrated that infant formulas with...

    Authors: Frank Jochum, Martina Meyer-Krott, Tina Hübler, Maja Lorenz, Raffi Bedikian, Joseph Zakarian, Anja Litzka, Guido Judex, Holger Hertzberg, Daniela Klee, Lothar Maurer, Martin Schacht, Adnan Al-Radhi, Jan Maier, Alexander Kröckel, Christian Faustmann…
    Citation: Molecular and Cellular Pediatrics 2023 10:7
    Content type: Research Published on:

  30. Metamizole is an analgesic, antipyretic, and spasmolytic drug in Germany only approved for the treatment of severe pain or high fever that does not respond to other measures. In recent years, an increased use ...

    Authors: Markos K. Tomidis Chatzimanouil, Ines Goppelt, Yvonne Zeissig, Ulrich J. Sachs and Martin W. Laass
    Citation: Molecular and Cellular Pediatrics 2023 10:6
    Content type: Mini Review Published on:

  31. Systemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (...

    Authors: Valentina Natoli, Amandine Charras, Gabriele Hahn and Christian M. Hedrich
    Citation: Molecular and Cellular Pediatrics 2023 10:5
    Content type: Review Published on:

  32. Bronchopulmonary dysplasia (BPD) is a multifactorial disease occurring as a consequence of premature birth, as well as antenatal and postnatal injury to the developing lung. BPD morbidity and severity depend o...

    Authors: I. Mižíková and B. Thébaud
    Citation: Molecular and Cellular Pediatrics 2023 10:4
    Content type: Review Published on:

  34. Advances in molecular biology are improving our understanding of the genetic causes underlying human congenital lower urinary tract (i.e., bladder and urethral) malformations. This has recently led to the iden...

    Authors: Caroline M. Kolvenbach, Gabriel C. Dworschak, Johanna M. Rieke, Adrian S. Woolf, Heiko Reutter, Benjamin Odermatt and Alina C. Hilger
    Citation: Molecular and Cellular Pediatrics 2023 10:2
    Content type: Mini Review Published on:

  35. Catheterization of the umbilical vessels has proven to be an effective and relatively rapid method for gaining central vascular access in neonates. However, it can be technically difficult, the procedure may l...

    Authors: Katarzyna Gendera, Stanimir Georgiev, Peter Ewert, Stefan Eckstein, Christoph Fusch and Niels Rochow
    Citation: Molecular and Cellular Pediatrics 2023 10:1
    Content type: Correspondence Published on:

  36. Non-invasive cardiac imaging has a growing role in diagnosis, differential diagnosis, therapy planning, and follow-up in children and adolescents with congenital and acquired cardiac diseases. This review is b...

    Authors: Meinrad Beer, Björn Schönnagel, Jochen Herrmann, Steffen Klömpken, Matthias Schaal, Michael Kaestner, Christian Apitz and Horst Brunner
    Citation: Molecular and Cellular Pediatrics 2022 9:21
    Content type: Review Published on:

  37. Insulin is used to treat neonatal hyperglycaemia when blood glucose concentrations are consistently high, and to treat neonatal diabetes. Within this brief report, a review of the existing literature is conduc...

    Authors: Paola Mian, Mathieu S. Bolhuis, J. Marina Maurer and Margriet van Stuijvenberg
    Citation: Molecular and Cellular Pediatrics 2022 9:20
    Content type: Review Article Published on:

  38. Shigellosis is one of the acute bowel infections and remains a serious public health problem in resource-poor countries. The present study aimed to survey the distribution of extended-spectrum β-lactamase (ESBL)-...

    Authors: Sahar Sabour, Amir Teimourpour, Jafar Mohammadshahi, Hadi Peeridogaheh, Roghayeh Teimourpour, Taher Azimi and Zahra Hosseinali
    Citation: Molecular and Cellular Pediatrics 2022 9:19
    Content type: Research Published on:

  39. Subcutaneous fat necrosis of the newborn (SCFN) is a rare disease occurring in the first days of life. Characteristically, the infants show hard nodules in subcutaneous tissue, purple or erythematous in color ...

    Authors: Leonie Frank, Stephanie Brandt and Martin Wabitsch
    Citation: Molecular and Cellular Pediatrics 2022 9:18
    Content type: Review Published on:

  41. In the neonatal lung, exposure to both prenatal and early postnatal risk factors converge into the development of injury and ultimately chronic disease, also known as bronchopulmonary dysplasia (BPD). The focu...

    Authors: Motaharehsadat Heydarian, Christian Schulz, Tobias Stoeger and Anne Hilgendorff
    Citation: Molecular and Cellular Pediatrics 2022 9:16
    Content type: Review Published on:

  42. Authors: Christoph Bührer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Berthold Koletzko, Burkhard Lawrenz, Walter Mihatsch, Carsten Posovszky and Silvia Rudloff
    Citation: Molecular and Cellular Pediatrics 2022 9:15
    Content type: Correction Published on:

    The original article was published in Molecular and Cellular Pediatrics 2022 9:14

  43. Human milk contains more than 150 different oligosaccharides, which together are among to the quantitatively predominant solid components of breast milk. The oligosaccharide content and composition of human mi...

    Authors: Christoph Bührer, Regina Ensenauer, Frank Jochum, Hermann Kalhoff, Berthold Koletzko, Burkhard Lawrenz, Walter Mihatsch, Carsten Posovszky and Silvia Rudloff
    Citation: Molecular and Cellular Pediatrics 2022 9:14
    Content type: Consensus Paper Published on:

    The Correction to this article has been published in Molecular and Cellular Pediatrics 2022 9:15

  44. Chronic kidney disease (CKD) is a global burden affecting both children and adults. Novel imaging modalities hold great promise to visualize and quantify structural, functional, and molecular organ damage. The...

    Authors: Colin A. Goebel, Emma Brown, Fabian B. Fahlbusch, Alexandra L. Wagner, Adrian Buehler, Thomas Raupach, Martin Hohmann, Moritz Späth, Neal Burton, Joachim Woelfle, Michael Schmidt, Andrea Hartner, Adrian P. Regensburger and Ferdinand Knieling
    Citation: Molecular and Cellular Pediatrics 2022 9:13
    Content type: Research Published on:

  45. Different gastrointestinal pathogens cause diarrhea which is a very common problem in children aged under 5 years. Among bacterial pathogens, Shigella is one of the main causes of diarrhea among children, and it ...

    Authors: Ahmad Nasser, Mehrdad Mosadegh, Taher Azimi and Aref Shariati
    Citation: Molecular and Cellular Pediatrics 2022 9:12
    Content type: Review Published on:

  46. Ultrasound elastography (USE) is a modality that in addition to fundamental B-mode, Doppler, and contrast-enhanced sonography is suitable to make qualitative and quantitative statements about the stiffness of ...

    Authors: Hans-Joachim Mentzel, Katja Glutig, Stephanie Gräger, Paul-Christian Krüger and Matthias Waginger
    Citation: Molecular and Cellular Pediatrics 2022 9:11
    Content type: Review Published on:

  47. Long noncoding RNAs (lncRNAs) are increasingly emerging as regulators across human development and disease, and many have been described in the context of hematopoiesis and leukemogenesis. These studies have y...

    Authors: Sina Neyazi, Michelle Ng, Dirk Heckl and Jan-Henning Klusmann
    Citation: Molecular and Cellular Pediatrics 2022 9:10
    Content type: Mini review Published on:

  48. Children with chronic kidney disease (CKD) suffer from inflammation and reactive metabolite-induced stress, which massively accelerates tissue and vascular aging. Peritoneal dialysis (PD) is the preferred dial...

    Authors: Maria Bartosova, Sotirios G. Zarogiannis and Claus Peter Schmitt
    Citation: Molecular and Cellular Pediatrics 2022 9:9
    Content type: Review Published on:

  49. Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD) remains one of the most important and lifelong sequelae following premature birth. Tremendous efforts have been undertake...

    Authors: Lena Holzfurtner, Tayyab Shahzad, Ying Dong, Lisa Rekers, Ariane Selting, Birte Staude, Tina Lauer, Annesuse Schmidt, Stefano Rivetti, Klaus-Peter Zimmer, Judith Behnke, Saverio Bellusci and Harald Ehrhardt
    Citation: Molecular and Cellular Pediatrics 2022 9:7
    Content type: Review Published on:

  50. Exclusive enteral nutrition (EEN) is the first-line therapy for pediatric-onset Crohn’s disease (CD) patients. CEDATA-GPGE® is the largest patient registry for children and adolescents with inflammatory bowel ...

    Authors: Sarah Peters, Serdar Cantez and Jan De Laffolie
    Citation: Molecular and Cellular Pediatrics 2022 9:6
    Content type: Research Published on:
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