"To evaluate how... different electrophysiological aspects contributed to spiking of the output MCs and sTCs, we used computational modeling. By exchanging the different cell properties in our modeled MCs and sTCs, we could evaluate each property's contribution to spiking differences between these cell types. This analysis suggested that the higher sensitivity of spiking in sTCs vs. MCs reflected both their larger monosynaptic OSN signal as well as their higher input resistance, while their smaller prolonged currents had a modest opposing effect. Taken together, our results indicate that both synaptic and intrinsic cellular features contribute to the production of parallel output channels in the olfactory bulb."

Model Type: Synapse

Region(s) or Organism(s): Olfactory bulb

Cell Type(s): Olfactory bulb (accessory) mitral cell; Olfactory bulb main tufted cell external

Transmitters: Glutamate

Simulation Environment: NEURON; Python

References:

Jones S, Zylberberg J, Schoppa N. (2020). Cellular and Synaptic Mechanisms That Differentiate Mitral Cells and Superficial Tufted Cells Into Parallel Output Channels in the Olfactory Bulb. Frontiers in cellular neuroscience. 14 [PubMed]