This model was used in the computational study of the strategies of protein transport in the context of JNK (c-JUN NH2-terminal kinase) transport along microtubules to the terminals of neuronal cells. Diffusion governs the first strategy. In the second strategy, proteins of the JNK signaling cascade bind to scaffolds and the whole protein-scaffold cargo is transported by kinesin motors along microtubules. Using the results from the simulations, the two distinct strategies for transport were compared.

Model Type: Axon

Model Concept(s): Spatio-temporal Activity Patterns; Simplified Models; Signaling pathways

Simulation Environment: MATLAB

References:

Koon YL, Koh CG, Chiam KH. (2014). Computational modeling reveals optimal strategy for kinase transport by microtubules to nerve terminals. PloS one. 9 [PubMed]