"The tetrodotoxin-resistant (TTX-r) persistent Na(+) current, attributed to Na(V)1.9, was recorded in small (< 25 mum apparent diameter) dorsal root ganglion (DRG) neurones cultured from P21 rats and from adult wild-type and Na(V)1.8 null mice. ... Numerical simulation of the up-regulation qualitatively reproduced changes in sensory neurone firing properties. ..." Note: models of NaV1.8 and NaV1.9 and also persistent and transient Na channels that collectively model Nav 1.1, 1.6, and 1.7 are present in this model.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Dorsal Root Ganglion (DRG) cell

Currents: I Na,p; I Na,t; I K

Genes: Nav1.1 SCN1A; Nav1.6 SCN8A; Nav1.7 SCN9A; Nav1.8 SCN10A; Nav1.9 SCN11A SCN12A

Model Concept(s): Ion Channel Kinetics; Action Potentials; Signaling pathways; Nociception

Simulation Environment: NEURON

Implementer(s): Morse, Tom [Tom.Morse at Yale.edu]

References:

Baker MD. (2005). Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones. The Journal of physiology. 567 [PubMed]