The paper describes an experimental model of the alpha rhythm generated by layer 4 pyramidal neurons in a visual cortex slice. The simulation model is derived from that of Traub et al. (2005) J Neurophysiol, developed for thalamocortical oscillations.

Model Type: Realistic Network

Region(s) or Organism(s): Thalamus; Neocortex

Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex U1 L6 pyramidal corticalthalamic GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex layer 4 pyramidal cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiny stellate cell

Currents: I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow

Model Concept(s): Brain Rhythms; Dendritic Action Potentials

Simulation Environment: FORTRAN

Implementer(s): Traub, Roger D [rtraub at us.ibm.com]

References:

Traub RD et al. (2020). Layer 4 pyramidal neuron dendritic bursting underlies a post-stimulus visual cortical alpha rhythm Nature Communications Biology, in press.