This is an Allen Cell Types Database model of a Scnn1a-Tg3-Cre neuron from layer 5 of the mouse primary visual cortex. The model was based on a traced morphology after filling the cell with biocytin and optimized using experimental electrophysiology data recorded from the same cell. The electrophysiology data was collected in a highly standardized way to facilitate comparison across all cells in the database. The model was optimized by a genetic algorithm that adjusted the densities of conductances placed at the soma to match experimentally-measured features of action potential firing. Data and models from the Allen Cell Types Database are made available to the community under the Allen Institute's Terms of Use and Citation Policy.

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex V1 L5B pyramidal pyramidal tract GLU cell

Currents: I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca

Model Concept(s): Parameter Fitting; Calcium dynamics; Vision

Simulation Environment: NEURON; Python

References:

No authors listed. (2015). Documentation Allen Cell Types Database.