This is a model network of prefrontal cortical microcircuit based primarily on rodent data. It includes 16 pyramidal model neurons, 2 fast spiking interneuron models, 1 regular spiking interneuron model and 1 irregular spiking interneuron model. The goal of the paper was to use this model network to determine the role of specific interneuron subtypes in persistent activity

Model Type: Realistic Network; Neuron or other electrically excitable cell

Cell Type(s): Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiking irregular interneuron

Currents: I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I h; I_Ks; I_KD

Receptors: GabaA; GabaB; AMPA; NMDA

Transmitters: Gaba; Glutamate

Model Concept(s): Activity Patterns; Synchronization; Active Dendrites

Simulation Environment: NEURON

Implementer(s): Sidiropoulou, Kyriaki [sidirop at imbb.forth.gr]; Konstantoudaki, Xanthippi [xeniakons at gmail.com]

References:

Konstantoudaki X, Papoutsi A, Chalkiadaki K, Poirazi P, Sidiropoulou K. (2014). Modulatory effects of inhibition on persistent activity in a cortical microcircuit model. Frontiers in neural circuits. 8 [PubMed]