Model of a cortical layer (L) 2 pyramidal neuron embedded in an anatomically realistic network of two barrel columns in rat vibrissal cortex. This model is used to investigate the effects of spatially and temporally specific inhibition from L1 inhibitory interneurons on the sensory-evoked subthreshold responses of the L2 pyramidal neuron, and can be used to create simulation results underlying Figures 3D, 4B, 4C and 4E from (Egger, Schmitt et al. 2015).

Model Type: Realistic Network; Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L2/3 pyramidal GLU cell

Receptors: GabaA; AMPA; NMDA

Transmitters: Gaba; Glutamate

Model Concept(s): Active Dendrites; Synaptic Integration; Sensory processing; Whisking

Simulation Environment: NEURON; Python

Implementer(s): Egger, Robert [robert.egger at nyumc.org]

References:

Egger R et al. (2015). Robustness of sensory-evoked excitation is increased by inhibitory inputs to distal apical tuft dendrites. Proceedings of the National Academy of Sciences of the United States of America. 112 [PubMed]