" ...To study the relationship between the (Ca2+ channel) T-distribution and several (LGN interneuron) IN response properties, we here run a series of simulations where we vary the T-distribution in a multicompartmental IN model with a realistic morphology. We find that the somatic response to somatic current injection is facilitated by a high T-channel density in the soma-region. Conversely, a high T-channel density in the distal dendritic region is found to facilitate dendritic signalling in both the outward direction (increases the response in distal dendrites to somatic input) and the inward direction (the soma responds stronger to distal synaptic input). ..."

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Thalamus

Cell Type(s): Thalamus lateral geniculate nucleus interneuron

Currents: I L high threshold; I T low threshold; I h; I K,Ca; I CAN; I_AHP

Model Concept(s): Dendritic Action Potentials; Active Dendrites; Conductance distributions

Simulation Environment: NEURON

Implementer(s): Allken, Vaneeda [vaneeda at gmail.com]

References:

Allken V, Chepkoech JL, Einevoll GT, Halnes G. (2014). The subcellular distribution of T-type Ca2+ channels in interneurons of the lateral geniculate nucleus. PloS one. 9 [PubMed]