This was the first application of compartmental modeling using the Rall approach to brain neurons. It combined multicompartmental representation of a mitral cell and a granule cell with the first Hodgkin-Huxley-like action potential to model antidromic activation of the mitral cell, followed by synaptic excitation of the granule cell and synaptic inhibition of the mitral cell. Combined with reconstruction of the field potentials generated around these neurons, and detailed comparisons with single cell recordings, it led to prediction of dendrodendritic interactions mediating self and lateral inhibition of the mitral cells by the granule cells. It has been regarded as the first computational model of a brain microcircuit (see also Shepherd and Brayton, 1979). Recreation of the model is pending.

Model Type: Neuron or other electrically excitable cell; Extracellular

Region(s) or Organism(s): Olfactory bulb

Model Concept(s): Simplified Models; Extracellular Fields; Evoked LFP; Olfaction

References:

Rall W, Shepherd GM. (1968). Theoretical reconstruction of field potentials and dendrodendritic synaptic interactions in olfactory bulb. Journal of neurophysiology. 31 [PubMed]