"Synaptic plasticity leads to long-term changes in excitability, whereas cellular homeostasis maintains excitability. Both these processes involve interactions between molecular events, electrical events, and network activity. Here I explore these intersections with a multilevel model that embeds molecular events following synaptic calcium influx into a multicompartmental electrical model of a CA1 hippocampal neuron. ..."

Model Type: Neuron or other electrically excitable cell; Molecular Network

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I A; I K; I K,Ca; I_AHP

Receptors: AMPA; NMDA

Model Concept(s): Synaptic Plasticity; Long-term Synaptic Plasticity; Multiscale; Homeostasis

Simulation Environment: GENESIS

Implementer(s): Bhalla, Upinder S [bhalla at ncbs.res.in]

References:

Bhalla US. (2011). Multiscale interactions between chemical and electric signaling in LTP induction, LTP reversal and dendritic excitability. Neural networks : the official journal of the International Neural Network Society. 24 [PubMed]