"... We present a detailed biochemical model of the CaMKII autophosphorylation and the protein signaling cascade governing the CaMKII dephosphorylation. ... it is shown that the CaMKII system can qualitatively reproduce results of plasticity outcomes in response to spike-timing dependent plasticity (STDP) and presynaptic stimulation protocols. This shows that the CaMKII protein network can account for both induction, through LTP/LTD-like transitions, and storage, due to its bistability, of synaptic changes."

Model Type: Synapse

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Model Concept(s): Detailed Neuronal Models; Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways

Simulation Environment: XPPAUT

Implementer(s): Graupner, Michael [michael.graupner at ens.fr]

References:

Graupner M, Brunel N. (2007). STDP in a bistable synapse model based on CaMKII and associated signaling pathways. PLoS computational biology. 3 [PubMed]