(Q14903410)

English

Bone morphogenetic protein 4

mammalian protein found in Mus musculus

bone morphogenetic protein 2B
Bmp4
bone morphogenetic protein 4
BMP-2B

In more languages

default for all languages

No label defined

No description defined

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Transforming growth factor-beta-related

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21275

Cystine-knot cytokine

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21275

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

heparin binding

determination method or standard

1 reference

14 February 2019

Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cytokine activity

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

transforming growth factor beta receptor binding

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

BMP receptor binding

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

protein binding

determination method or standard

6 references

14 February 2019

LRP2/megalin is required for patterning of the ventral telencephalon

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

A novel chordin-like BMP inhibitor, CHL2, expressed preferentially in chondrocytes of developing cartilage and osteoarthritic joint cartilage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

chemoattractant activity

determination method or standard

growth factor activity

determination method or standard

protein homodimerization activity

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

extracellular space

determination method or standard

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

extracellular space

determination method or standard

5 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

biological process

eye development

determination method or standard

1 reference

14 February 2019

BMP4 substitutes for loss of BMP7 during kidney development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

germ cell development

determination method or standard

1 reference

14 February 2019

BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

embryonic skeletal system morphogenesis

determination method or standard

1 reference

14 February 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

mesenchymal cell differentiation involved in renal system development

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

ureteric bud development

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of protein phosphorylation

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

renal system process

determination method or standard

1 reference

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of endothelial cell differentiation

determination method or standard

1 reference

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of immature T cell proliferation in thymus

determination method or standard

bud elongation involved in lung branching

determination method or standard

1 reference

14 February 2019

Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

tendon cell differentiation

determination method or standard

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

anatomical structure formation involved in morphogenesis

determination method or standard

1 reference

14 February 2019

Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

ureter epithelial cell differentiation

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of cell cycle

determination method or standard

outflow tract morphogenesis

determination method or standard

1 reference

14 February 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

mesenchymal to epithelial transition involved in metanephros morphogenesis

determination method or standard

post-embryonic development

determination method or standard

3 references

14 February 2019

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

determination method or standard

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

determination method or standard

BMP signaling pathway involved in renal system segmentation

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cranial suture morphogenesis

determination method or standard

1 reference

14 February 2019

FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

odontogenesis of dentin-containing tooth

determination method or standard

3 references

14 February 2019

Regulation of mammalian tooth cusp patterning by ectodin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Regulation of mammalian tooth cusp patterning by ectodin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of chondrocyte differentiation

determination method or standard

1 reference

14 February 2019

Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

blood vessel development

determination method or standard

1 reference

14 February 2019

Genetic variability and rodent models of human aging

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of mitotic nuclear division

determination method or standard

determination method or standard

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

prostate gland morphogenesis

determination method or standard

tissue development

determination method or standard

1 reference

14 February 2019

Inactivation of mouse Twisted gastrulation reveals its role in promoting Bmp4 activity during forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

smooth muscle tissue development

determination method or standard

1 reference

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of endothelial cell proliferation

determination method or standard

1 reference

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

BMP signaling pathway involved in heart induction

determination method or standard

negative regulation of epithelial cell proliferation

determination method or standard

1 reference

14 February 2019

Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

metanephric collecting duct development

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

inner ear receptor cell differentiation

determination method or standard

1 reference

14 February 2019

Rudiment incisors survive and erupt as supernumerary teeth as a result of USAG-1 abrogation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

mesodermal cell fate determination

determination method or standard

1 reference

14 February 2019

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

metanephros development

determination method or standard

type B pancreatic cell development

determination method or standard

regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

negative regulation of cell population proliferation

determination method or standard

3 references

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Noggin is required for normal lobe patterning and ductal budding in the mouse prostate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

steroid hormone mediated signaling pathway

determination method or standard

mammary gland formation

determination method or standard

1 reference

14 February 2019

Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of collagen biosynthetic process

determination method or standard

cell fate commitment

determination method or standard

1 reference

14 February 2019

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

common-partner SMAD protein phosphorylation

determination method or standard

glomerular visceral epithelial cell development

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

SMAD protein signal transduction

determination method or standard

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

kidney development

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

BMP4 substitutes for loss of BMP7 during kidney development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

lung development

determination method or standard

1 reference

14 February 2019

Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

ureter smooth muscle cell differentiation

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cardiac muscle cell differentiation

determination method or standard

embryonic digit morphogenesis

determination method or standard

1 reference

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

epithelial-mesenchymal cell signaling

determination method or standard

1 reference

14 February 2019

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of thymocyte apoptotic process

determination method or standard

mesenchymal cell differentiation involved in kidney development

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of cell death

determination method or standard

regulation of odontogenesis of dentin-containing tooth

determination method or standard

1 reference

14 February 2019

Antagonistic Interactions between FGF and BMP Signaling Pathways: A Mechanism for Positioning the Sites of Tooth Formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

BMP signaling pathway involved in ureter morphogenesis

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

mesenchymal cell proliferation involved in ureteric bud development

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

smooth muscle cell differentiation

determination method or standard

1 reference

14 February 2019

Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

lymphoid progenitor cell differentiation

determination method or standard

epithelium development

determination method or standard

1 reference

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of transcription, DNA-templated

determination method or standard

4 references

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

deltoid tuberosity development

determination method or standard

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of prostatic bud formation

determination method or standard

branching involved in ureteric bud morphogenesis

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cartilage development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of kidney development

determination method or standard

negative regulation of MAP kinase activity

determination method or standard

lens induction in camera-type eye

determination method or standard

1 reference

14 February 2019

BMP4 is essential for lens induction in the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of cell differentiation

determination method or standard

1 reference

14 February 2019

Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

branching involved in prostate gland morphogenesis

determination method or standard

1 reference

14 February 2019

Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

erythrocyte differentiation

determination method or standard

1 reference

14 February 2019

BMP4 and Madh5 regulate the erythroid response to acute anemia

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

smoothened signaling pathway

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

camera-type eye development

determination method or standard

secondary heart field specification

determination method or standard

negative regulation of phosphorylation

determination method or standard

positive regulation of pri-miRNA transcription by RNA polymerase II

determination method or standard

1 reference

14 February 2019

Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of cell fate commitment

determination method or standard

regulation of branching involved in prostate gland morphogenesis

determination method or standard

1 reference

14 February 2019

Computer-based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo-insufficient for bone morphogenetic protein 4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cell differentiation

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of branching involved in lung morphogenesis

determination method or standard

1 reference

14 February 2019

TNF-alpha represses transcription of human Bone Morphogenetic Protein-4 in lung epithelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

chondrocyte differentiation

determination method or standard

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of cartilage development

determination method or standard

1 reference

14 February 2019

Regulation of BMP-dependent chondrogenesis in early limb mesenchyme by TGFbeta signals

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

organ induction

determination method or standard

1 reference

14 February 2019

Formation of Rathke's pouch requires dual induction from the diencephalon

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of bone mineralization

determination method or standard

positive regulation of epithelial cell proliferation

determination method or standard

negative regulation of cell proliferation involved in heart morphogenesis

determination method or standard

regulation of morphogenesis of a branching structure

determination method or standard

1 reference

14 February 2019

Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of apoptotic process

determination method or standard

4 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of ossification

determination method or standard

3 references

14 February 2019

Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

endochondral ossification

determination method or standard

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of smooth muscle cell proliferation

determination method or standard

1 reference

14 February 2019

Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

BMP signaling pathway

determination method or standard

6 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

embryonic skeletal system development

determination method or standard

1 reference

14 February 2019

The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of metanephric comma-shaped body morphogenesis

determination method or standard

determination method or standard

mesenchymal cell proliferation involved in ureter development

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of osteoblast differentiation

determination method or standard

osteoblast differentiation

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

hematopoietic progenitor cell differentiation

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of BMP signaling pathway

determination method or standard

1 reference

14 February 2019

Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of gene expression

determination method or standard

embryonic cranial skeleton morphogenesis

determination method or standard

1 reference

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

dorsal/ventral neural tube patterning

determination method or standard

1 reference

14 February 2019

Restriction of BMP4 activity domains in the developing neural tube of the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

anterior/posterior axis specification

determination method or standard

1 reference

14 February 2019

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of transcription, DNA-templated

determination method or standard

positive regulation of epidermal cell differentiation

determination method or standard

branching morphogenesis of an epithelial tube

determination method or standard

trachea formation

determination method or standard

1 reference

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

specification of animal organ position

determination method or standard

1 reference

14 February 2019

Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of glomerular mesangial cell proliferation

determination method or standard

positive regulation of smooth muscle cell proliferation

determination method or standard

positive regulation of vascular endothelial growth factor receptor signaling pathway

determination method or standard

1 reference

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

intermediate mesodermal cell differentiation

determination method or standard

pulmonary artery endothelial tube morphogenesis

determination method or standard

pituitary gland development

determination method or standard

1 reference

14 February 2019

Formation of Rathke's pouch requires dual induction from the diencephalon

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of endothelial cell proliferation

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of cardiac muscle fiber development

determination method or standard

positive regulation of cell migration

determination method or standard

1 reference

14 February 2019

DMH1, a small molecule inhibitor of BMP type i receptors, suppresses growth and invasion of lung cancer

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

determination method or standard

cellular response to growth factor stimulus

determination method or standard

1 reference

14 February 2019

Comparative analysis of TGF beta s, BMPs, IGF1, msxs, fibronectin, osteonectin and bone sialoprotein gene expression during normal and in vitro-induced odontoblast differentiation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of pathway-restricted SMAD protein phosphorylation

determination method or standard

4 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

mesoderm formation

determination method or standard

BMP signaling pathway involved in nephric duct formation

determination method or standard

negative regulation of mesenchymal cell proliferation involved in ureter development

determination method or standard

glomerular capillary formation

determination method or standard

1 reference

14 February 2019

Bmp in podocytes is essential for normal glomerular capillary formation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of endothelial cell migration

determination method or standard

4 references

14 February 2019

BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

multicellular organism development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of metanephric S-shaped body morphogenesis

determination method or standard

neural tube closure

determination method or standard

1 reference

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

vasculature development

determination method or standard

1 reference

14 February 2019

Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

embryonic morphogenesis

determination method or standard

1 reference

14 February 2019

Distinct functions for Bmp signaling in lip and palate fusion in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

protein localization to nucleus

determination method or standard

positive regulation of apoptotic process

determination method or standard

3 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

mesodermal cell differentiation

determination method or standard

1 reference

14 February 2019

Evidence for involvement of activin A and bone morphogenetic protein 4 in mammalian mesoderm and hematopoietic development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of branching involved in ureteric bud morphogenesis

determination method or standard

4 references

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

10 September 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

10 September 2018

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

forebrain development

determination method or standard

neuron fate commitment

determination method or standard

bone development

determination method or standard

1 reference

14 February 2019

Gene cloning and expression of a bone morphogenetic protein derived from a murine osteosarcoma

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cloacal septation

determination method or standard

1 reference

14 February 2019

Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

camera-type eye morphogenesis

determination method or standard

1 reference

14 February 2019

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

16 references

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Msx1 is required for the induction of Patched by Sonic hedgehog in the mammalian tooth germ

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Msx1 controls inductive signaling in mammalian tooth morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Id genes are direct targets of bone morphogenetic protein induction in embryonic stem cells

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Molecular mechanisms of cell and tissue interactions during early tooth development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Murine cerberus homologue mCer-1: a candidate anterior patterning molecule

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Two BMP responsive elements, STAT, and bZIP/HNF4/COUP motifs of the hepcidin promoter are critical for BMP, SMAD1, and HJV responsiveness

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of SMAD protein signal transduction

determination method or standard

negative regulation of glomerulus development

determination method or standard

embryonic hindlimb morphogenesis

determination method or standard

1 reference

14 February 2019

glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

epithelial to mesenchymal transition involved in endocardial cushion formation

determination method or standard

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

outflow tract septum morphogenesis

determination method or standard

membranous septum morphogenesis

determination method or standard

pharyngeal arch artery morphogenesis

determination method or standard

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

aortic valve morphogenesis

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

4 references

24 April 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

24 April 2018

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P21275&geneProductId=UniProtKB:P21275

determination method or standard

cardiac jelly development

determination method or standard

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of cell proliferation involved in outflow tract morphogenesis

determination method or standard

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive chemotaxis

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cardiac right ventricle morphogenesis

determination method or standard

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

coronary vasculature development

determination method or standard

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

BMP signaling pathway involved in heart development

determination method or standard

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

pulmonary valve morphogenesis

determination method or standard

negative regulation of extrinsic apoptotic signaling pathway

determination method or standard

1 reference

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

muscular septum morphogenesis

determination method or standard

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

apoptotic process involved in endocardial cushion morphogenesis

determination method or standard

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

endocardial cushion development

determination method or standard

1 reference

14 February 2019

BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

endoderm development

determination method or standard

1 reference

14 February 2019

Pelota regulates the development of extraembryonic endoderm through activation of bone morphogenetic protein (BMP) signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of epithelial to mesenchymal transition

determination method or standard

1 reference

14 February 2019

Bmp signaling represses Vegfa to promote outflow tract cushion development.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

determination method or standard

1 reference

14 February 2019

Bmp signaling represses Vegfa to promote outflow tract cushion development.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of signaling receptor activity

determination method or standard

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of gene expression

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Critical function of Prdm14 for the establishment of the germ cell lineage in mice

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

ovarian follicle development

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of cell population proliferation

determination method or standard

4 references

14 February 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Bmp4 is required for tracheal formation: a novel mouse model for tracheal agenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of calcium ion transport into cytosol

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of gene expression

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of neuron projection development

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cellular response to oxidative stress

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of oligodendrocyte differentiation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of hepatocyte differentiation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cellular response to dexamethasone stimulus

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of branching involved in ureteric bud morphogenesis

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of store-operated calcium channel activity

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of mesenchymal stem cell proliferation

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

positive regulation of endothelial cell apoptotic process

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

5 references

14 February 2019

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Bmp4 signaling is required for outflow-tract septation and branchial-arch artery remodeling

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

BMP signaling pathway

determination method or standard

7 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of apoptotic process

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of apoptotic process

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

regulation of MAPK cascade

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

cell development

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

SMAD protein signal transduction

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

renal system development

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

negative regulation of branching involved in ureteric bud morphogenesis

determination method or standard

5 references

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Six1 regulates Grem1 expression in the metanephric mesenchyme to initiate branching morphogenesis

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

14 February 2019

Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P21275

determination method or standard

Transforming growth factor beta, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21275

Transforming growth factor-beta, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21275

TGF-beta, propeptide

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P21275

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000073720

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000073720

ENSMUSP00000098242

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000098242

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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