Abstract
The emerging viral diseases haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS) are a cause of global concern as they are increasingly reported from newer regions of the world. The hantavirus species causing HFRS include Hantaan virus, Seoul virus, Puumala virus, and Dobrava-Belgrade virus while Sin Nombre virus was responsible for the 1993 outbreak of HCPS in the Four Corners Region of the US. Humans are accidental hosts and get infected by aerosols generated from contaminated urine, feces and saliva of infected rodents. Rodents are the natural hosts of these viruses and develop persistent infection. Human to human infections are rare and the evolution of the virus depends largely on that of the rodent host. The first hantavirus isolate to be cultured, Thottapalayam virus, is the only indigenous isolate from India, isolated from an insectivore in 1964 in Vellore, South India. Research on hantaviruses in India has been slow but steady since 2005. Serological investigation of patients with pyrexic illness revealed presence of anti-hantavirus IgM antibodies in 14.7% of them. The seropositivity of hantavirus infections in the general population is about 4% and people who live and work in close proximity with rodents have a greater risk of acquiring hantavirus infections. Molecular and serological evidence of hantavirus infections in rodents and man has also been documented in this country. The present review on hantaviruses is to increase awareness of these emerging pathogens and the threats they pose to the public health system.
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Abbreviations
- ANDV:
-
Andes virus
- DOBV:
-
Dobrava-Belgrade virus
- ELISA:
-
enzyme-linker immunosorbent assay
- GPC:
-
glycoprotein precursor
- HFRS:
-
haemorrhagic fever with renal syndrome
- HCPS:
-
hantavirus cardiopulmonary syndrome
- HPS:
-
hantavirus pulmonary syndrome
- HTNV:
-
Hantaan virus
- IFA:
-
immunofluorescence assays
- IgM:
-
immunoglobulin M
- NCR:
-
non-coding region
- NE:
-
nephropathia epidemica
- nt:
-
nucleotides
- ORF:
-
open reading frame
- PUUV:
-
Puumala virus
- RdRp:
-
RNA-dependent RNA polymerase
- SEOV:
-
Seoul virus
- SNV:
-
Sin Nombre virus
- TPMV:
-
Thottapalyam virus
References
Arikawa J, Takashima I and Hashimoto N 1985 Cell fusion by haemorrhagic fever with renal syndrome (HFRS) viruses and its application for titration of virus infectivity and neutralizing antibody; Arch. Virol. 86 303–313
Avsic-Zupanc T, Toney A, Anderson K, Chu Y K and Schmaljohn C 1995. Genetic and antigenic properties of Dobrava virus: a unique member of the hantavirus genus, family Bunyaviridae; J. Gen. Virol. 76 2801–2808
Blakqori G, Kochs G, Haller O and Weber F 2003. Functional L polymerase of La Crosse virus allows in vivo reconstitution of recombinant nucleocapsids; J. Gen. Virol. 84 1207–1214
Bruno P, Hassel LH, Brown J, Tanner W and Lau A 1990. The protean manifestations of hemorrhagic fever with renal syndrome. A retrospective review of 26 cases from Korea; Ann. Internal Med. 113 385–391
Carey DE, Reuben R, Panicker K N, Shope R E and Myers R M 1971. Thottapalayam virus: A presumptive arbovirus isolated from a shrew in India; Indian J. Med. Res. 59 1758–1760
Chandy S, Mitra S, Sathish N, Vijayakumar T S, Abraham O C, Jesudason M V, Abraham P, Yoshimatsu K, Arikawa J and Sridharan G 2005 A pilot study for serological evidence of hantavirus infection in human population in south India; Indian J. Med. Res. 122 211–215
Chandy S, Yoshimatsu K, Ulrich RG, Mertens M, Okumura M, Rajendran P, John GT, Balraj V, Muliyil J, Mammen J, Abraham P, Arikawa J and Sridharan G 2008 Seroepidemiological study on hantavirus infections in India; Trans. R. Soc. Trop. Med. Hyg. 102 70–74
Chu Y K, Rossi C, Leduc J W, Lee H W, Schmaljohn C S and Dalrymple J M 1994 Serological relationships among viruses in the Hantavirus genus, family Bunyaviridae; Virology 198 196–204
Clement J P 2003 Hantavirus; Antiviral Res. 57 121–127
Clement J, Maes P, Muthusethupathi M, Nainan G and van Ranst M 2006 First evidence of fatal hantavirus nephropathy in India, mimicking Leptospirosis; Nephrol. Dial. Transplant 21 826–827
Dournon E, Moriniere B, Matheron S, Girard P, Gonzalez J and Hirsch F 1984 HFRS after a wild rodent bite in the Haute-Savoie and risk of exposure to Hantaan like virus in Paris laboratory; Lancet 1 676–677
Duchin J S, Koster F T, Peters C J, Simpson G L, Tempest B, Zaki S R, Ksiazek T G, Rollin P E 1994 Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease; N. Engl. J. Med. 330 949–955
Elgh F, Lundkvist A, Alexeyev O A, Stenlund H, Avsic-Zupanc T, Hjelle B, Lee H W, Smith K J 1997 Serological diagnosis of hantavirus infections by an enzyme-linked immunosorbent assay based on the detection of immunoglobulin G and M responses to recombinant nucleocapsid proteins of five viral serotypes; J. Clin. Microbiol. 35 1120–1130
Elgh F, Lundkvist A, Alexeyev O A, Wadell G and Juto P 1996. A major antigenic domain for the human humoral response to Puumala virus nucleocapsid protein is located at the aminoterminus; J. Virol. Methods 59 161–172
Elliot R M, Schmaljohn C S and Collett M S 1991 Bunyaviridae: genome structure and gene expression; Curr. Top. Microbiol. Immunol. 169 91–141
Flick R and Pettersson R F 2001 Reverse genetics system for Uukuniemi virus (Bunyaviridae): RNA polymerase I-catalyzed expression of chimeric viral RNAs; J. Virol. 75 1643–1655
Glass G E, Childs J E, Korch G W and LeDuc J W 1988 Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus); Epidemiol. Infect. 101 459–472
Gloriani -Bargaza N, Cabanban A, Graham R R and Florese R H 1999 Hantavirus infection in two Filipino patients with jaundice; Philos. J. Microbiol. Infect. Dis. 28 21–23
Goren J, Gerding M N, Jordans J G, Clement J P, Nieuwenhuijs J H and Osterhaus A D 1995 Hantavirus infections in The Netherlands: epidemiology and disease; Epidemiol. Infect. 114 373–383
Groen J, Jordans H G, Clement J P, Rooijakkers E J, UytdeHaag F G, Dalrymple J, Van der Groen G and Osterhaus A D 1991 Identification of hantavirus serotypes by testing of post infection sera in immunofluorescence and enzyme-linked immunosorbent assays. J. Med. Virol. 33 26–32
Henderson W W, Monroe M C, St. Jeor S C, Thayer W P, Rowe J E, Peters C J and Nichol S T 1995. Naturally occurring Sin Nombre virus genetic reassortants; Virology 214 602–610
Heung-Chul K, Terry K A, Sung-Tae C, Brett W C, Chu S Y, Ki-Joon S, Luck-Ju B and Jin-Won S 2007 Seroepidemiological survey of rodents collected at a US military installation, Yongsan garrison, Seoul, Republic of Korea; Military Med. 172 759–764
Hjelle B, Goade D, Torrez-Martinez N, Lang-Williams M, Kim J, Harris R L and Rawlings J A 1996 Hantavirus pulmonary syndrome, renal insufficiency and myositis associated with infection by Bayou hantavirus; Clin. Infect. Dis. 23 495–500
Houck M A, Qin H and Roberts H R 2001 Hantavirus transmission: Potential role of ectoparasites; Vec Borne Zoo Dis. 1 75–79
Jay M, Ascher M S, Chomel B B, Madon M, Sesline D, Enqe B, Hjelle B and Ksiasek T G 1997 Seroepidemiological studies of hantavrus infection among wild rodents in California; Emerg. Infect. Dis. 3 183–190
Jenison S, Yamada T, Morris C, Anderson B, Torrez-Martinez N, Keller N and Hjelle B 1994 Characterization of human antibody responses to four corners hantavirus infections among patients with hantavirus pulmonary syndrome; J. Virol. 68 3000–3006
Johnson K M 2001 Hantaviruses: history and overview; Curr. Top. Microbiol. Immunol. 256 1–14
Kallio-Kokko H, Lundkvist A, Plyusnin A, Avsic-Zupanc T, Vaheri A and Vapalahti O 2000 Antigenic properties and diagnostic potential of recombinant Dobrava virus nucleocapsid protein; J. Med. Virol. 61 266–274
Kaukinen P, Vaheri A and Plyusnin A 2005 Hantavirus nucleocapsid protein: a multifunctional molecule with both housekeeping and ambassadorial duties; Arch. Virol. 150 1693–1713
Khaiboullina S F, Morzunov S P and St Jeor S C 2005 Hantaviruses: molecular biology, evolution and pathogenesis; Curr. Mol. Med. 5 773–790
Khan A S, Gaviria J M, Rollin P E, Hlady W G, Ksiazek T G, Armstrong L R, Greenman R, Ravkov E et al 1996 Hantavirus pulmunory syndrome in Florida: association with the newly identified Black Creek Canal virus; Am. J. Med. 100 46–48
Kim Y S, Ahn C, Han J S, Kim S, Lee J S and Lee P W 1995 Hemorrhagic fever with renal syndrome caused by the Seoul virus; Nephron 71 419–427
Krüger D H, Ulrich R and Lundkvist A A 2001 Hantavirus infections and their prevention; Microbes Infect. 3 1129–44
Kukkonen S K, Vaheri A and Plyusnin A 2005 L protein, the RNA-dependent RNA polymerase of hantaviruses; Arch. Virol. 150 533–556
Lednicky J A 2003 Hantaviruses. A short review; Arch. Pathol. Lab. Med. 127 30–35
Lee H W and Cho H J 1981 Electron microscope appearance of Hantaan virus, the causative agent of Korean haemorrhagic fever; Lancet 1 1070–1072
Lee H W and Johnson K M 1982 Laboratory-acquired infections with Hantaan virus, the etiologic agent of Korean hemorrhagic fever; J. Infect. Dis. 146 645–651
Liu Y X, Feng D, Zhang Q, Jia N, Zhao Z T, De Vlas S J, Li J, Zhang P H, Yang H et al 2007 Key differentiating features between scrub typhus and hemorrhagic fever with renal syndrome in northern China; Am. J. Trop. Med. Hyg. 76 801–805
Lloyd G, Bowen E T, Jones N and Pendry A 1984 HFRS outbreak associated with laboratory rats in the UK; Lancet 1 1175–1176
Löber C, Anheier B, Lindow S, Klenk H D and Feldmann H 2001 The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA; Virology 289 224–229
Lundkvist A, Bjosten S, Niklasson B and Ahlborg N 1995 Mapping of B-cell determinants in the nucleocapsid protein of Puumala virus definition of epitopes specific for acute Immunoglobulin G recognition in humans; Clin. Diagn. Lab. Immunol. 2 82–86
Lundkvist A, Hukic M, Horling J, Gilljam M, Nichol S and Niklasson B 1997 Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia Herzegovina evidence of highly cross neutralizing antibody responses in early patient sera; J. Med. Virol. 53 51–59
Lundkvist A and Niklasson B 1994 Hemorrhagic fever with renal syndrome and other hantavirus infections; Rev. Med. Virol. 4 177–184
Markotic A, Kuzman I, Babic K, Gagro A, Nichol S, Ksiasek T G, Rabatic S and Dekaris D 2001 Double trouble: Hemorrhagic fever with renal syndrome and leptospirosis; Scand. J. Infect. Dis. 34 221–224
McCaughey C and Hart C A. 2000 Hantaviruses; Med. Microbiol. 49 587–599
Mehta S and Jiandani P 2007 Ocular features of hantavirus infection; Indian J. Ophthalmol. 5 378–380
Mertz G J 2002. Bunyaviridae: Bunyaviruses, Phleboviruses, Nairoviruses and Hantaviruses; in Clinical virology 2n edition (eds) D DRichman, R J Whitley and F G Hayden (Washington, DC: ASM Press) pp 921–948
Mertz GJ, Hjelle B, Crowley M, Iwamoto G, Tomicic V and Vial P A 2006 Diagnosis and treatment of new world hantavirus infections; Curr. Opin. Infect. Dis. 19 437–442
Meyer B J and Schmaljohn C S. 2000 Persistent hantavirus infections: characteristics and mechanisms; Trends Microbiol. 8 61–67
Montgomery J M, Ksiazek T G and Khan A S 2007 Hantavirus pulmonary syndrome: the sound of a mouse roaring; J. Infect. Dis. 195 1553–1555
Morse S S and Schluederberg A 1990 Emerging viruses the evolution of viruses and viral diseases; J. Infect. Dis. 162 1–7
Muranyi W, Bahr U, Zeier M and van der Woude F J 2005 Hantavirus infection; J. Am. Soc. Nephrol. 16 3669–3679
Nakamura T, Yanagihara R, Gibbs CJ Jr and Gajdusek D C. 1985 Immune spleen cell-mediated protection against fatal Hantaan virus infection in infant mice; J. Infect. Dis. 151 691–697
Nichol ST. 2001 Bunyaviruses; in Fields virology 4th edition (eds) D M Knipe and P M, Howley (Philadelphia: Lippincott, Williams and Wilkins) pp 1603–1633
Okumura M, Yoshimatsu K, Kumperasart S, Nakamura I, Ogino M, Taruishi M, Sungdee A, Pattamadilok S, Ibrahim N I, Erlina S, Agui T, Yanagihara R and Arikawa J 2007 Development of serological assays for Thottapalayam virus, an insectivore borne hantavirus; Clin. Vaccine Immunol. 14 173–181
Overturf G D 2005 Clinical Sin Nombre hantaviral infections in children; Pediatr. Infect. Dis. J. 24 373–374
Papa A, Johnson A, Strockron P C, Bowen M D, Spiropoulou C F, Alexiou Daniel S, Ksiazek T G, Nichol S T and Antoniadis A 1998 Retrospective serological and genetic study of the distribution of hantaviruses in Greece; J. Med. Virol. 55 321–327
Parrington M A and Kang C Y 1990 Nucleotide sequence analysis of the S genomic segment of Prospect Hill virus: comparison with the prototype hantavirus; Virology 175 167–175
Peters C J and Khan A S 2002 Hantavirus pulmonary syndrome: The new American Hemorrhagic fever; Clin. Infect. Dis. 34 1224–1231
Peters C J, Simpson G L and Levy H 1999 Spectrum of hantavirus infection: hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome; Annu. Rev. Med. 50 531–545
Plyusnin A 2002 Genetics of hantaviruses:Implications to taxonomy; Arch. Virol. 147 665–682
Plyusnin A, Vapalahti O and Vaheri A 1996 Hantaviruses: genome structure, expression and evolution; J. Gen. Virol. 77 2677–2687
Ravkov E V, Nichol S T, Peters C J and Compans R W 1998 Role of actin microfilaments in Black Creek Canal virus morphogenesis; J. Virol. 72 2865–2870
Schmaljohn C S and Dalrymple J M 1983 Analysis of Hantaan virus RNA: Evidence for a new genus of bunyaviridae; Virology 131 482–491
Schmaljohn C S, Jennings G B, Hay J and Dalrymple J M 1986 Coding strategy of the S genome of Hantaan virus; Virology 155 633–643
Schmaljohn C S, Schmaljohn A L and Dalrymple J M 1987 Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order; Virology; 157 31–39
Schmaljohn C S, Arikawa J, Hasty S E, Rasmussen L, Lee W H, Lee P W, Dalrymple J M 1988 Conservation of antigenic properties and sequences encoding the envelope proteins of prototype Hantaan virus and two virus isolates from Korean hemorrhagic fever patients; J. Gen. Virol. 69 1949–1955
Schmaljohn C S 1990 Nucleotide sequence of the L genome segment of Hantaan virus; Nucleic Acids Res. 18 6728
Schmaljohn C S, Chu Y K, Schmaljohn A L and Dalrymple J M 1990 Antigenic subunits of Hantaan virus expressed by baculovirus and vaccinia virus recombinants; J. Virol. 64 3162–3170
Schmaljohn C and Hjelle B. 1997 Hantaviruses: a global disease problem; Emerg. Infect. Dis. 3 95–104
Severson W, Xu X, Kuhn M, Senutovitch N, Thokala M, Ferron F, Longhi S, Canard B and Jonsson C B 2005 Essential amino acids of the hantaan virus N protein in its interaction with RNA; J. Virol. 79 10032–10039
Sjolander K B, Elgh F, Kallio Kokko H, Vapalahti O, Hagglund M, Palmcrantz V, Juto P, Vaheri A, Niklasson B and Lundkvist A 1997 Evaluation of serological methods for diagnosis of Puumala hantavirus infection (nephropathia epidemica); J. Clin. Microbiol. 35 3264–3268
Sjolander K B and Lundkvist A 1999 Dobrava virus infection: serological diagnosis and cross reactions to other hantaviruses; J. Virol. Methods 80 137–143
Spiropoulou C F, Morzunov S, Feldmann H, Sanchez A, Peters C J and Nichol S T 1994 Genome structure and variability of a virus causing hantavirus pulmonary syndrome; Virology 200 715–723
Stohwasser R, Giebel L B, Zoller L, Bautz E K and Darai G 1990 Molecular characterization of the RNA S segment of nephropathia epidemica virus strain Hällnas B1; Virology 174 79–86
Tager F M, Vial P C, Castillo C H, Godoy P M, Hjelle B and Ferrés M G 2003 Hantavirus prevalence in the IX region of Chile; Emerg. Infect. Dis. 9 827–832
Ulrich R, Hjelle B, Pitra C and Kruger D H 2002. Emerging viruses: the case ‘hantavirus’; Intervirology 45 318–327
Van Regenmortel M H V, Fauquet C M, Bishop D H L, Carstens E B, Estes M K, Lemon S M, Maniloff J, Mayo M A, McGeoch D J, Pringle C R and Wickner R B 2000 Virus Taxonomy Seventh Report of the International Committee on Taxonomy of Viruses (San Diego: Academic Press)
Van Ypersele de Strihou C 1991 Clinical features of hemorrhagic fever with renal syndrome in Europe; Kidney Int. (Suppl.35) 40 S80–S83
Vapalahti O, Kallio-Kokko H, Närvänen A, Julkunen I, Lundkvist A, Plyusnin A, Lehväslaiho H and Brummer-Korvenkontio M 1995 Human B-cell epitopes of Puumala virus nucleocapsid protein, the major antigen in early serological response; J. Med. Virol. 46 293–303
Vapalahti O, Lundkvist A and Vaheri A 2001 Human Immune response, host genetics and severity of disease; Curr. Top. Microbiol. Immunol. 256 153–169
Wells R M, Sosa Estani S and Yadon Z E 1997 An unusual hantavirus outbreak in southern Argentina: person to person transmission? Hantavirus Syndrome Study Group for Patagonia; Emerg. Infect. Dis. 3 171–174
Wichman D, Slenczka W, Alter P, Boehm S and Feldmann H 2001 Hemorrhagic fever with renal syndrome: Diagnostic problems with a known disease; J. Clin. Microbiol. 39 3414–3416
Xiao S Y, Leduc J W, Chu Y K and Schmaljohn C S 1994 Phylogenetic analyses of virus isolates in the genus Hantavirus, family Bunyaviridae; Virology 198 205–217
Yadav P D, Vincent M J and Nichol S T 2007 Thottapalayam virus is genetically distant to the rodent-borne hantaviruses, consistent with its isolation from the Asian house shrew(Suncus murinus); Virol. J. 4 80
Young J C, Mills J N, Enria D A, Dolan N E, Khan A S and Ksiazek T G1998 New world hantaviruses; Br. Med. Bull. 54 659–673
Zeller H G, Karabatsos N, Calisher C H, Digoutte J P, Cropp C B, Murphy F A and Shope R E 1989 Electron microscopic and antigenic studies of uncharacterized viruses II. Evidence suggesting the placement of viruses in the family Bunyaviridae; Arch. Virol. 108 211–227
Zoller L, Yang S, Gott P, Bautz E K and Darai G 1993 Use of recombinant proteins of the Hantaan and the Nephropathia Epidemica serotypes of hantaviruses as immunodiagnostic antigens; J. Med. Virol. 39 200–207
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Chandy, S., Abraham, P. & Sridharan, G. Hantaviruses: an emerging public health threat in India? A review. J Biosci 33, 495–504 (2008). https://doi.org/10.1007/s12038-008-0068-x
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DOI: https://doi.org/10.1007/s12038-008-0068-x