Nothing Special   »   [go: up one dir, main page]
Skip to main content
Springer Nature Link
Log in

Meta-analysis of the relationship between Epstein-Barr virus infection and clinicopathological features of patients with gastric carcinoma

  • Research Paper
  • Published:
Science China Life Sciences Aims and scope Submit manuscript

Abstract

Epstein-Barr virus (EBV) infection has been causally associated with occurrence of many malignant neoplasms. EBV-encoded small RNAs (EBERs) have been detected from about 10% of gastric carcinoma tissue cells, suggesting that EBV infection is associated with the development of gastric carcinoma. The present study pooled the data from the papers concerning EBV-related gastric cancers and performed a meta-analysis of 22 research papers. Among these papers, a total of 5475 cases with gastric cancer were enrolled, of whom 411 cases were found EBV-positive, with the EBV-positive rate being 7.5%. Among the EBV-positive gastric cancer cases, the detection rate was 11.1% in males and 3.0% in females. Compared with EBV-negative gastric cancer, EBV-positive gastric cancer had less lymph node metastasis. Based on the histological typing, of the EBV-positive gastric cancers, the diffuse type was 8.1%, and intestinal type was 8.0%. The examined specimen types included stored paraffin blocks and fresh surgically removed specimens, their EBV positive rates were 7.9% and 6.5% respectively. In terms of geographical distribution, the detection rate of EBV-positive gastric cancer was 9.4% in America, 6.1% in Asia and 9.1% in Europe. Meta-analysis showed that EBV infection occurred only in gastric cancer tissue cells and was significantly associated with the patients’ gender, lymph node metastases, and the location where tumor tissue generated and geographical distribution (P<0.05), but was not significantly associated with the patients’ histological types of tumor and the types of specimens (P>0.05). These results suggested that EBV-positive gastric cancer has distinct clinicopathological features.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Konturek P C, Konturek S J, Brzozowski T. Gastric cancer and Helicobacter pylori infection. J Physiol Pharmacol, 2006, 57: 51–65

    Google Scholar 

  2. Thompson M P, Kurzrock R. Epstein-Barr virus and cancer. Clin Cancer Res, 2004, 10: 803–821 10.1158/1078-0432.CCR-0670-3, 1:CAS:528:DC%2BD2cXhtFCnsrY%3D, 14871955

    Article  PubMed  CAS  Google Scholar 

  3. Burke A P, Yen T S, Shekitka K M, et al. Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction. Mod Pathol, 1990, 3: 377–380 1:STN:280:DyaK3czgtFOmug%3D%3D, 2163534

    PubMed  CAS  Google Scholar 

  4. Shibata D, Weiss L M. Epstein-Barr virus-associated gastric Adenocarcinoma. Am J Pathol, 1992, 140: 769–774 1:STN:280:DyaK383it1SgtQ%3D%3D, 1314023

    PubMed  CAS  PubMed Central  Google Scholar 

  5. Imai S, Koizumi S, Sugiura M, et al. Gastric carcinoma: Monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci USA, 1994, 91: 9131–9135 10.1073/pnas.91.19.9131, 1:CAS:528:DyaK2cXmtVajtLo%3D, 8090780

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  6. Gulley M L, Pulitzer D R, Eagan P A, et al. Epstein-Barr virus infection is an early event in gastric carcinogenesis and is independent of bcl-2 Expression and p53 accumulation. Hum Pathol, 1996, 27: 20–27 10.1016/S0046-8177(96)90133-1, 1:STN:280:DyaK287ksVOksQ%3D%3D, 8543306

    Article  PubMed  CAS  Google Scholar 

  7. Uozaki H, Fukayama M. Epstein-Barr virus and gastric carcinoma-viral carcinogenesis through epigenetic mechanisms. Int J Clin Exp Pathol, 2008, 1: 198–216 1:CAS:528:DC%2BD1cXpt1Gnu78%3D, 18784828

    PubMed  CAS  PubMed Central  Google Scholar 

  8. zur Hausen A, Brink A A, Craanen M E, et al. Unique transcription pattern of Epstein-Barr virus (EBV) in EBV-carrying gastric adenocarcinomas: expression of the transforming BARF1 gene. Cancer Res, 2000, 60: 2745–2748 10825150

    PubMed  Google Scholar 

  9. Li S Y, Hou L T, Zhou T J. Study on the influence of EBV infection to bcl-2 expression in gastric carcinoma patients. Clin Focus, 2006, 21: 319–321

    Google Scholar 

  10. Li S Y, Zhu L H, Zhou T J. Study on EBV infection and expression of c-erbB-2 in gastric carcinoma patients. Chin J Zoonoses, 2006, 22: 606–608 1:CAS:528:DC%2BD2sXhtlWgtrrO

    CAS  Google Scholar 

  11. Li S Y, Zhang K, Zhou T J. Relativity between EBV infection and expression of cyclin D1 in gastric carcinoma patients. J Fourth Military Med Univ, 2006, 27: 1932–1933 1:CAS:528:DC%2BD1cXhtVektL4%3D

    CAS  Google Scholar 

  12. Li S Y, Hu J H, Zhou T J. Analyse the relativity of EBV infection with gastric carcinomas. Chin J Gerontol, 2007, 27: 2323–2325

    Google Scholar 

  13. Ryan J L, Morgan D R, Dominguez R L, et al. High levels of Epstein-Barr virus DNA in latently infected gastric adenocarcinoma. Lab Invest, 2009, 89: 80–90 10.1038/labinvest.2008.103, 1:CAS:528:DC%2BD1MXhtVKntQ%3D%3D, 19002111

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  14. Vo Q N, Geradts J, Gulley M L, et al. Epstein-Barr virus in gastric adenocarcinoma: Associated with ethnicity and CDKN2A promoter methylation. J Clin Pathol, 2002, 55: 669–675 10.1136/jcp.55.9.669, 1:STN:280:DC%2BD38vmtlSntg%3D%3D, 12194996

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  15. Truong C D, Feng W, Li W, et al. Characteristics of Epstein-Barr virus-associated gastric cancer: A study of 235 cases at a comprehensive cancer center in U.S.A. J Exp Clin Cancer Res, 2009, 28: 1–9 10.1186/1756-9966-28-14

    Article  Google Scholar 

  16. Alipov G, Nakayama T, Nakashima M, et al. Epstein-Barr virus associated gastric carcinoma in Kazakhstan. World J Gastroenterol, 2005, 11: 27–30 15609391

    Article  PubMed  PubMed Central  Google Scholar 

  17. Lee H S, Chang M S, Yang H K, et al. Epstein-Barr virus-positive gastric carcinoma has a distinct protein expression profile in comparison with Epstein-Barr virus-negative carcinoma. Clin Cancer Res, 2004, 10: 1698–1705 10.1158/1078-0432.CCR-1122-3, 1:CAS:528:DC%2BD2cXhvFCltro%3D, 15014022

    Article  PubMed  CAS  Google Scholar 

  18. Herrera-Goepfert R, Akiba S, Koriyama C, et al. Epstein-Barr virus-associated gastric carcinoma: Evidence of age-dependence among a Mexican population. World J Gastroenterol, 2005, 11: 6096–6103 16273633

    Article  PubMed  PubMed Central  Google Scholar 

  19. van Beek J, zur Hausen A, Klein Kranenbarg E, et al. EBV-positive gastric adenocarcinomas: A distinct clinicopathologic entity with a low frequency of lymph node involvement. J Clin Oncol, 2004, 22: 664–670 10.1200/JCO.2004.08.061, 14966089

    Article  PubMed  Google Scholar 

  20. Wang K J, Wang R T. Meta-analysis on the epidemiology of helicobacter pylori infection in China. Chin J Epidemiol, 2003, 24: 443–446

    Google Scholar 

  21. Lee J H, Kim S H, Han S H, et al. Clinicopathological and molecular characteristics of Epstein-Barr virus-associated gastric carcinoma: A meta-analysis. J Gastroenterol Hepatol, 2009, 24: 354–365 10.1111/j.1440-1746.2009.05775.x, 19335785

    Article  PubMed  Google Scholar 

  22. Lima V P, de Lima M A, André A R, et al. H pylori (Cag A) and Epstein-Barr virus infection in gastric carcinomas: Correlation with p53 mutation and c-Myc, Bcl-2 and Bax expression. World J Gastroenterol, 2008, 14: 884–891 10.3748/wjg.14.884, 1:CAS:528:DC%2BD1cXjsFyksrc%3D, 18240345

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  23. Lopes L F, Bacchi M M, Elgui-de-Oliveira D, et al. Epstein-Barr virus infection and gastric carcinoma in Sao Paulo State, Brazil. Braz J Med Biol Res, 2004, 37: 1707–1712 1:STN:280:DC%2BD2crksVyhtQ%3D%3D, 15517087

    Article  PubMed  CAS  Google Scholar 

  24. Begnami M D, Montagnini A L, Vettore A L, et al. Differential expression of apoptosis related proteins and nitric oxide synthases in Epstein Barr associated gastric carcinomas. World J Gastroenterol, 2006, 12: 4959–4965 1:CAS:528:DC%2BD28XhtVehtrfM, 16937490

    PubMed  CAS  PubMed Central  Google Scholar 

  25. Luo B, Wang Y, Wang X F, et al. Correlation of Epstein-Barr virus and its encoded proteins with Helicobacter pylori end expression of c-met and c-myc in gastric carcinomas. World J Gastroenterol, 2006, 12: 1842–1848 1:CAS:528:DC%2BD28Xksl2ntLk%3D, 16609989

    PubMed  CAS  PubMed Central  Google Scholar 

  26. Abdirad A, Ghaderi-Sohi S, Shuyama K, et al. Epstein-Barr virus associated gastric carcinoma: a report from Iran in the last four decades. Diagn Pathol, 2007, 2: 1–9 10.1186/1746-1596-2-25

    Article  Google Scholar 

  27. Shibata D, Hawes D, Stemmermann G N, et al. Epstein-Barr virus-associated gastric adenocarcinoma among Japanese Americans in Hawaii. Cancer Epidemiol Biomarkers Prev, 1993, 2: 213–217 1:STN:280:DyaK3szgs1Wktw%3D%3D, 8391356

    PubMed  CAS  Google Scholar 

  28. Karim N, Pallesen G. Epstein-Barr virus(EBV) and gastric carcinoma in Malaysian patients. Malaysian J Pathol, 2003, 25: 45–47

    Google Scholar 

  29. Oda K, Koda K, Takiguchi N, et al. Detection of Epstein-Barr virus in gastric carcinoma cells and surrounding lymphocytes. Gastric Cancer, 2003, 6: 173–178 10.1007/s10120-003-0247-2, 14520531

    Article  PubMed  Google Scholar 

  30. Jung I M, Chung J K, Kim Y A, et al. Epstein-Barr virus, Beta catenin, and E-cadherin in gastric carcinomas. J Korean Med Sci, 2007, 22: 855–861 10.3346/jkms.2007.22.5.855, 1:CAS:528:DC%2BD2sXhsVWrtb7O, 17982235

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  31. Chang M S, Lee H S, Jung E J, et al. Role and prognostic significance of proapoptotic proteins in Epstein-Barr virus-infected gastric carcinomas. Anticancer Res, 2007, 27: 785–792 1:CAS:528:DC%2BD2sXltVKmtr0%3D, 17465203

    PubMed  CAS  Google Scholar 

  32. Kang G H, Lee S, Kim W H, et al. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol, 2002, 160: 787–794 1:CAS:528:DC%2BD38XisVemsbg%3D, 11891177

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  33. van Rees B P, Caspers E, zur Hausen A, et al. Different pattern of allelic loss in Epstein-Barr virus-positive gastric cancer with emphasis on the p53 tumor suppressor pathway. Am J Pathol, 2002, 161: 1207–1213 12368194

    Article  PubMed  PubMed Central  Google Scholar 

  34. van Beek J, zur Hausen A, Kranenbarg E K, et al. A rapid and reliable enzyme immunoassay PCR-based screening method to identify EBV-carrying gastric carcinomas. Mod Pathol, 2002, 15: 870–877 10.1097/01.MP.0000024147.43288.B1, 12181273

    Article  PubMed  Google Scholar 

  35. Nicholls J M, Agathanggelou A, Fung K, et al. The association of squamous cell carcinomas of the nasopharynx with Epstein-Barr virus shows geographical variation reminiscent of Burkitt’s lymphoma. J Pathol, 1997, 183: 164–168 10.1002/(SICI)1096-9896(199710)183:2<164::AID-PATH919>3.0.CO;2-J, 1:STN:280:DyaK1c%2FltFCltQ%3D%3D, 9390028

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Life Sciences, Hebei University, Baoding, 071002, China

    ShuYing Li & XiaoYu Zhao

  2. Department of Pathogenic Biology, Faculty of Biological Science, North China Coal Medical College, Tangshan, 063000, China

    ShuYing Li

  3. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (Chinese CDC), State Key Laboratory for Infectious Disease Prevention and Control (SKLID), Beijing, 100052, China

    HaiJun Du, Zhan Wang, Ling Zhou & Yi Zeng

Authors
  1. ShuYing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. HaiJun Du
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Zhan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ling Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. XiaoYu Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yi Zeng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Ling Zhou or Yi Zeng.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Li, S., Du, H., Wang, Z. et al. Meta-analysis of the relationship between Epstein-Barr virus infection and clinicopathological features of patients with gastric carcinoma. Sci. China Life Sci. 53, 524–530 (2010). https://doi.org/10.1007/s11427-010-0082-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11427-010-0082-8

Keywords

Search

Navigation