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Chemokines and chemokine receptors in allergic rhinitis: from mediators to potential therapeutic targets

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Abstract

Allergic rhinitis (AR) is an immune-mediated inflammatory condition characterized by immune cell infiltration of the nasal mucosa, with symptoms of rhinorrhea, sneezing, nasal obstruction, and itchiness. Currently, common medication for AR is anti-inflammatory treatment including intranasal steroids, oral, or intranasal anti-histamines, and immunotherapy. These strategies are effective to the majority of patients with AR, but some patients under medication cannot achieve symptom relieve and suffer from bothersome side effects, indicating a demand for novel anti-inflammatory treatment as alternatives. Chemokines, a complex superfamily of small, secreted proteins, were initially recognized for their chemotactic effects on various immune cells. Chemokines constitute both physiological and inflammatory cell positioning systems and mediate cell localization to certain sites via interaction with their receptors, which are expressed on responding cells. Chemokines and their receptors participate in the sensitization, early phase response, and late phase response of AR by promoting inflammatory cell recruitment, differentiation, and allergic mediator release. In this review, we first systemically summarize chemokines and chemokine receptors that are important in AR pathophysiology and then discuss potential strategies targeting chemokines and their receptors for AR therapy.

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Acknowledgements

We thank Dr. Xiaofeng Yu for discussions and suggestions for the project.

Funding

This work was supported by the National Natural Science Foundation of China (81902133) to Dr. Yajing Fu.

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Authors and Affiliations

  1. Department of Laboratory Medicine, China Medical University, Shenyang, China

    Zhan Li, Sihua Yu, Yongjun Jiang & Yajing Fu

  2. Department of Clinical Immunology, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, China

    Yongjun Jiang & Yajing Fu

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  1. Zhan Li
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  2. Sihua Yu
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ZL and YF wrote the manuscript based on discussions with SY and prepared the table. YJ revised and examined the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Yajing Fu.

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Li, Z., Yu, S., Jiang, Y. et al. Chemokines and chemokine receptors in allergic rhinitis: from mediators to potential therapeutic targets. Eur Arch Otorhinolaryngol 279, 5089–5095 (2022). https://doi.org/10.1007/s00405-022-07485-6

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