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ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors

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Fig. 1

References

  1. Capper D, Jones DTW, Sill M et al (2018) DNA methylation-based classification of central nervous system tumours. Nature 555:469–474

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Koelsche C, Mynarek M, Schrimpf D et al (2018) Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations. Acta Neuropathol 136:327–337

    Article  CAS  PubMed  Google Scholar 

  3. Korshunov A, Ryzhova M, Jones DT et al (2012) LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathol 124:875–878

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sahm F, Jakobiec FA, Meyer J et al (2016) Somatic mutations of DICER1 and KMT2 are frequent in intraocular medulloepitheliomas. Genes Chromosomes Cancer 55:418–427

    Article  CAS  PubMed  Google Scholar 

  5. Schultz K, Williams GM, Kamihara J et al (2018) DICER1 and associated conditions: identification of at-risk individuals and recommended surveillance strategies. Clin Cancer Res 24:2251–2261

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Spence T, Sin-Chan P, Picard D et al (2014) CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity. Acta Neuropathol 128:291–303

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Wu MK, Vujanic GM, Fahiminiya S et al (2018) Anaplastic sarcomas of the kidney are characterized by DICER1 mutations. Mod Pathol 31:169–178

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We thank the “Société Française des Cancers de l’Enfant” and «Enfants et Santé» for their support. We are grateful to the neuropathologists from the French rare tumor network (RENOCLIP) and to Sylvie Duclos and Karen Silva for their help. Samples were retrieved from the CHU de Montpellier tumor bank BB-0033-00031 and from the CHU de Toulouse tumor bank BB-0033-00014. We thank Josh Waterfall and Sarah Lesagere for their help to edit the manuscript.

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Authors and Affiliations

  1. Departments of Pathology, Neurosurgery, Oncopediatry, Genetics and Molecular Biology, Toulouse University Hospital, Toulouse, France

    Emmanuelle Uro-Coste, Aurore Siegfried, Sergio Boetto, Anne-Isabelle Bertozzi, Marion Gambart, Isabelle Oliver-Petit, Sophie Julia, Fréderique Savagner & Marie-Bernadette Delisle

  2. INSERM U1037, Cancer Research Center of Toulouse (CRCT), Toulouse, France

    Emmanuelle Uro-Coste & Aurore Siegfried

  3. Departments of Genetics and of Oncopediatry and Young Adults, Curie Institute, Paris, France

    Julien Masliah-Planchon, Maud Blanluet, Lisa Golmard & Franck Bourdeaut

  4. INSERM U830, Laboratory of Translational Research in Pediatric Oncology, SIREDO Pediatric Oncology Center, Curie Institute, Paris, France

    Julien Masliah-Planchon & Franck Bourdeaut

  5. Hopp Children’s Cancer Center at the NCT (KiTZ), Heidelberg, Germany

    Sander Lambo & Marcel Kool

  6. German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany

    Sander Lambo & Marcel Kool

  7. Departments of Pathology, Neurosurgery, Oncopediatry, and Genetic, Montpellier University Medical Center, Montpellier, France

    Thomas Roujeau, Gilles Palenzuela, Isabelle Coupier & Valérie Rigau

  8. Inserm UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Toulouse, France

    Fréderique Savagner

  9. Plateforme Post-génomique P3S, Faculté de Médecine Pierre et Marie Curie, Paris, France

    Badreddine Mohand-Oumoussa

  10. Department of Pathology, Sainte Anne University Medical Center, Paris, France

    Arnault Tauziede-Espariat

  11. Department of Pathology, Marseille University Hospital, Marseille, France

    Dominique Figarella-Branger

  12. Department of Pathology and Neuropathology, la Timone Hospital and UMR CNRS 7058, Neurophysiopathology Institute (INP), Aix-Marseille University, Marseille, France

    Dominique Figarella-Branger

  13. Institute for Neuroscience of Montpellier (INM), INSERM U1051, Montpellier University Hospital, Montpellier, France

    Valérie Rigau

Authors
  1. Emmanuelle Uro-Coste
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  2. Julien Masliah-Planchon
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  4. Maud Blanluet
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  5. Sander Lambo
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  6. Marcel Kool
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  7. Thomas Roujeau
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  8. Sergio Boetto
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  10. Anne-Isabelle Bertozzi
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  11. Marion Gambart
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  12. Isabelle Coupier
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  13. Isabelle Oliver-Petit
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  14. Lisa Golmard
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  15. Sophie Julia
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  16. Fréderique Savagner
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  17. Badreddine Mohand-Oumoussa
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  18. Arnault Tauziede-Espariat
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  19. Marie-Bernadette Delisle
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  20. Dominique Figarella-Branger
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  21. Franck Bourdeaut
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  22. Valérie Rigau
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Corresponding author

Correspondence to Emmanuelle Uro-Coste.

Electronic supplementary material

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Supplementary Table

 1: Listing of the 78 childhood cancer genes of the targeted gene sequencing panel (Illumina_TruSeq Custom Amplicon) (PDF 27 kb)

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Uro-Coste, E., Masliah-Planchon, J., Siegfried, A. et al. ETMR-like infantile cerebellar embryonal tumors in the extended morphologic spectrum of DICER1-related tumors. Acta Neuropathol 137, 175–177 (2019). https://doi.org/10.1007/s00401-018-1935-7

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  • DOI: https://doi.org/10.1007/s00401-018-1935-7

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