Abstract
This work tries to go a step further in the development of methods based on automatic learning techniques to parse and interpret data relating to cognitive decline (CD). There have been studied the neuropsychological tests of 267 consultations made over 30 patients by the Alzheimer’s Patient Association of Gran Canaria in 2005. The Sanger neural network adaptation for missing values treatment has allowed making a Principal Components Analysis (PCA) on the successfully obtained data. The results show that the first three obtained principal components are able to extract information relating to functional, cognitive and instrumental sintomatology, respectively, from the test. By means of these techniques, it is possible to develop tools that allow physicians to quantify, view and make a better pursuit of the sintomatology associated to the cognitive decline processes, contributing to a better knowledge of these ones.
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References
López-Pousa, S.: La demencia: concepto y epidemiología. Enfermedad de Alzheimer y otras demencias. Médica Panamericana, Madrid , 33–42 (2006)
Andersen, C.K., Wittrup-Jensen, K.U., Lolk, A., Andersen, K., Kragh-Sorensen, P.: Ability to perform activities of daily living is the main factor affecting quality of life in patients with dementia. Health Qual Life Outcomes 2 (2004)
DeKosky, S.: Early intervention is key to successful management of Alzheimer disease. Alzheimer Disease and Associated Disorders 17, S99–S104 (2003)
Doody, R.S.: Refining treatment guidelines in Alzheimer’s disease. Geriatrics Suppl. 14–20 (2005)
Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study: Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales. The Lancet 357, 169–175 (2001)
Solomon, P., Murphy, C.: Should we screen for Alzheimer’s disease? Geriatrics 60, 26–31 (2005)
Borson, S., Scanlan, J.M., Watanabe, J., Tu, S.P., Lessing, M.: Simplifying detection of cognitive impairment: comparison of the Mini-Cog and Mini-Mental State Examination in a multiethnic sample. Journal of the American Geriatrics Society 53, 871–874 (2005)
Nestor, P.J., Scheltens, P., Hodges, J.R.: Advances in the early detection of Alzheimer’s desease. Nature Reviews Neuroscience 5, S31–S34 (2004)
Damian, M., Kreis, M., Krumm, B., Hentschel, F.: Optimized neuropsychological procedures at different stages of dementia diagnostics. Journal of the Neurological Sciences 229, 95–101 (2005)
Folstein, M.F., Folstein, S.E., McHugh, P.R.: Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. Journal of psychiatric research 12, 189–198 (1975)
Reisberg, B.: Functional Assessment Staging (FAST). Psychopharmacology Bulletin 24, 653–659 (1988)
Fernandez-Viadero, C., Verduga, R., Crespo, D.: Biomarcadores biológicos del envejecimiento. Biogerontología, Universidad de Cantabria, Cantabira (2006)
Katz, S.C., Ford, A.B., Moskowitz, R.W.: Studies of illness in the aged. The index of ADL: a standardized measure of biological and psychosocial function. JAMA 185, 914–919 (1963)
Mahoney, F.I., Barthel, D.: Functional evaluation: The Barthel Index. Maryland State Medical Journal 14, 61–65 (1965)
Lawton, M.P., Brody, E.M.: Assessment of older people: self-mantaining and instrumental activities of daily living. Gerontologist 9, 179–186 (1969)
Sanger, T.D.: Optimal Unsupervised Learning in a Single-Layer Linear Feedforward Neural N. Neural Networks 2, 459–473 (1989)
Dimantaras, K., Kung, S.Y.: Principal Component Neural Networks: Theory and Applications. John Wiley and Sons, New York (1996)
Foldiak, P.: Adaptive network for optimal linear feature extraction. In: Proceedings of the International Joint Conference on Neural Networks I, pp. 401–405 (1989)
Rubner, J., Tavan, P.: A self-organizing network for principal component analysis. Europhysics Letters 10, 693–698 (1989)
Fiori, S.: An Experimental Comparison of Three PCA Neural Networks. Neural Processing Letters 11, 209–218 (2000)
Samad, T., Harp, S.A.: Self-organization with partial data. Network 3, 205–212 (1992)
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García Báez, P., Suárez Araujo, C.P., Fernández Viadero, C., Regidor García, J. (2007). Automatic Prognostic Determination and Evolution of Cognitive Decline Using Artificial Neural Networks. In: Yin, H., Tino, P., Corchado, E., Byrne, W., Yao, X. (eds) Intelligent Data Engineering and Automated Learning - IDEAL 2007. IDEAL 2007. Lecture Notes in Computer Science, vol 4881. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77226-2_90
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DOI: https://doi.org/10.1007/978-3-540-77226-2_90
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