The United Nations proposed the sustainable development goals as a universal call towards balanced social, economic and environmental sustainability. Within these goals, the responsible production of innovative devices that bring improvements in quality of life are pursued. Electrochemical sensors can provide in situ monitoring in samples of clinical, environmental, food, forensic, and industrial interests. Nevertheless, the sustainability and cost of production of sensors require novel strategies and materials in the framework of a circular economy. In this context, this topical collection seeks to capture innovative contributions towards the development of sustainable and low-cost electrochemical (bio)sensors. Manuscripts involving green substrate materials for sensors, such as paper, biopolymers, cellulose, clay, biomass (e.g., biochar), pencil, conductive inks/pastes, as well as affordable manufacturing methods, including screen and stencil printing, inkjet-printing, 3D-printing (extrusion-based techniques), pencil drawing, and laser scribing will be considered. Novel approaches to produce environmental-friendly and inexpensive electrochemical sensors will be accepted. Applications may include but are not limited to clinical, environmental, food, forensic, and industrial samples.