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Current Status of the Development of Blood-Based Point-of-Care Microdevices

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Mechanical Sciences

Abstract

Blood is one of the most common human tissues required to assess the human health condition. In a conventional setup, disease diagnosis includes consultation with a health practitioner, blood analysis, and follow up. Overall, the diagnosis process is time consuming and delays the timely treatment of the patients. Point-of-care technology (POCT) is rapidly progressing toward providing innovative and efficient solutions for diagnosing. Point-of-care (POC) devices are portable, provide on-site testing of the blood within few minutes, and utilize small volume of blood. Lab-on-chip microfluidic devices play a key role in the progress of POCT. Several lab-on-chip (LOC) microdevices have been reported in literature for the successful detection of various diseases using blood as a sample fluid. Here, we review blood-based lab-on-chip microfluidics devices dedicated to the point-of-care technology. Our review focuses on the technologies and designs of various dedicated microdevices toward disease diagnostics in reference with blood components such as plasma, red blood cells, white blood cells, platelets, and circulating tumor cells. The review should therefore serve as a useful reference for the development of future blood-based POC devices.

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Authors and Affiliations

  1. Department of Mechanical Engineering, IIT Bombay, Powai, Mumbai, 400076, India

    Vijai Laxmi & Amit Agrawal

  2. Birla Institute of Technology and Science Pilani, Goa Campus, Goa, 403726, India

    Siddhartha Tripathi

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  1. Vijai Laxmi
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  1. Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati, India

    Uday S. Dixit

  2. Department of Mechanical Engineering, Indian Institute of Technology Guwahati, Guwahati, India

    Santosha Kumar Dwivedy

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Laxmi, V., Tripathi, S., Agrawal, A. (2021). Current Status of the Development of Blood-Based Point-of-Care Microdevices. In: Dixit, U., Dwivedy, S. (eds) Mechanical Sciences. Springer, Singapore. https://doi.org/10.1007/978-981-15-5712-5_8

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