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Lutropin Alfa

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Abstract

  • ▲ Lutropin alfa is the first and only recombinant human form of luteinizing hormone (LH) developed for use in the stimulation of follicular development.

  • ▲ Dose-finding studies revealed a significant dosedependent increase in the rate of optimal follicular development among women with hypogonadotropic hypogonadism and profound LH deficiency (<1.2 IU/L) who received subcutaneous lutropin alfa 0–225 IU/day plus follitropin alfa.

  • ▲ Similarly, in a double-blind, randomized study, the rate of optimal follicular development was significantly higher in women with hypogonadotropic hypogonadism and profound LH deficiency receiving subcutaneous lutropin alfa 75 IU/day plus follitropin alfa than in those receiving placebo plus follitropin alfa.

  • ▲ Lutropin alfa with follitropin alfa may also be of benefit in certain subgroups of normogonadotropic women (e.g. those with an inadequate response to prior follitropin alfa monotherapy, those aged ≥35 years, and those with profound LH downregulation or who required excessive exogenous follitropin alfa). However, one study in older women (≥35 years) did not show any advantage of lutropin alfa supplementation.

  • ▲ Once-daily subcutaneous lutropin alfa was generally well tolerated in hypogonadotropic hypogonadal women, with the majority of adverse events being of mild to moderate severity.

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Notes

  1. The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgments and Disclosures

The article was reviewed by: C. Alviggi, R. Clarizia and G. De Placido, Department of Obstetrics, Gynecology, Urology and Reproductive Medicine, Federico II University of Naples, Naples, Italy; P. Humaidan, The Fertility Clinic, Viborg Hospital (Skive), Skive, Denmark.

The preparation of this review was not supported by any external funding. During the peer review process, the manufacturer of the agent under review was offered an opportunity to comment on this article. Changes resulting from comments received were made on the basis of scientific and editorial merit.

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Authors and Affiliations

  1. Wolters Kluwer Health ¦ Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand

    Sohita Dhillon & Gillian M. Keating

  2. Wolters Kluwer Health, Conshohocken, Pennsylvania, USA

    Sohita Dhillon & Gillian M. Keating

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  1. Sohita Dhillon
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  2. Gillian M. Keating
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Correspondence to Sohita Dhillon.

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Dhillon, S., Keating, G.M. Lutropin Alfa. Drugs 68, 1529–1540 (2008). https://doi.org/10.2165/00003495-200868110-00005

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  • DOI: https://doi.org/10.2165/00003495-200868110-00005

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