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Chronic red laser treatment induces hypotensive effect in two-kidney one-clip model of renovascular hypertension in rat

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Abstract

To evaluate whether the chronic effect of photobiomodulation therapy (PBM) on systolic arterial pressure (SAP) from two kidneys one clip (2 K-1C) hypertension animal models can cause a hypotensive effect. Serum levels of nitric oxide were also analyzed and the assessment of lipid peroxidation of the thoracic aorta artery. Male Wistar rats were used. Hypertensive animals (2 K-1C) with Systolic arterial pressure (SAP) greater than or equal to 160 mmHg were used. Systolic arterial pressure (SAP) was determined by the tail plethysmography technique. Normotensive (2 K) and hypertensive (2 K-1C) rats were treated to PBM for 4 weeks using a laser whose irradiation parameters were: red wavelength (λ) = 660 nm: operating continuously; 56 s per point (3 points) spot size = 0.0295 cm2; average optical power of 100 mW; energy of 5.6 J per point; irradiance of 3.40 W/cm2; fluency of 190 J/cm2 per point. The application was on the animals tails, at 3 different points simultaneously, in contact with the skin. To assess serum nitrite and nitrate (NOx) levels, blood collection was performed after chronic PBM treatment, 24 h after the last laser application. The evaluation of the lipid peroxidation of the thoracic aorta artery was performed by measuring the concentration of hydroperoxide by the FOX method. Chronic photobiomodulation therapy (PBM) by red laser (660 nm) can induce a hypotensive effect in 64% of 2 K-1C hypertensive animals, which we say responsive animals. There was no difference in serum NO levels 24 h after the last red laser application, between treated and non-treated groups. Aortic rings from 2 K-1C hypertensive animals present a higher lipid peroxidation. The chronic PBM treatment by red laser decreased aortic rings lipid peroxidation in hypertensive responsive groups, compared to control. our results indicate that chronic PBM made by red laser has an important hypotensive effect in renovascular hypertensive models, by a mechanism that involves decrease in oxidative stress from vascular beds.

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Acknowledgements

Special thanks to Professor Evelin Capellari Cárnio from Department of Nursing, general and specialized, Nursing School of Ribeirão Preto, University of São Paulo – USP, Ribeirão Preto, SP, Brazil for auxiliary the experiments of Serum Nitrite and Nitrate quantification with the equipment NO Analyzer 280i.

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Authors and Affiliations

  1. Departamento de Biofísica e Farmacologia, Universidade Federal Do Rio Grande Do Norte (UFRN), Natal, RN, Brazil

    Manuela dos Santos Carvalho Schiavon

  2. Departamento de Ciências Fisiológicas, Universidade Federal de São Carlos (UFSCar), São Carlos, SP, CEP 13565-905, Brazil

    Luis Henrique Oliveira de Moraes, Thiago Francisco de Moraes, Tereza Cristina Buzinari, José Carlos Rapozo Mazulo Neto & Gerson Jhonatan Rodrigues

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Contributions

MS and GR: Conceptualization; MS, TM and JN: Data curation; LM, TB and GR: Formal analysis; GR: Funding acquisition; MS: Investigation; GR: Methodology; GR: Project administration; GR: Resources; GR: Supervision; GR: Validation; GR: Visualization; LM, TB and GR: Roles/Writing—original draft; LM and GR: Writing—review & editing.

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Correspondence to Luis Henrique Oliveira de Moraes.

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dos Santos Carvalho Schiavon, M., de Moraes, L.H.O., de Moraes, T.F. et al. Chronic red laser treatment induces hypotensive effect in two-kidney one-clip model of renovascular hypertension in rat. Lasers Med Sci 38, 252 (2023). https://doi.org/10.1007/s10103-023-03918-8

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