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Green synthesis and antibacterial evaluation of some new 1-aryl-3-(1-aryl-1H-[1,2,3]triazol-4-yl)-propenones

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Abstract

A new series of 1-aryl-3-(1-aryl-1H-[1,2,3]triazol-4-yl)propenones (6a–6j) was synthesized by condensation of substituted acetophenones (5a–5c) with substituted 1-aryl-1H-[1,2,3]triazole-4-carbaldehydes (4a–4d) in the presence of potassium hydroxide under conditions of grinding and microwave irradiation. All the newly synthesized compounds were characterized by the IR, NMR, and mass spectroscopic analyses and their antibacterial activity against gram-positive and gram-negative bacterial strains was evaluated. Among the compounds synthesized, better activity was exhibited by 6a, 6c, 6f, 6g, and 6i.

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References

  1. Dhar, D.N., The Chemistry of Chalcones and Related Compounds, New York Wiley, 1981.

    Google Scholar 

  2. Bohm, B.A., Dey, P.M., and Harborne, J.B., Meth. Plant. Biochem., 1989, vol. 1, p 237.

    Article  CAS  Google Scholar 

  3. Narender, T., Shweta., S., Tanvir, K., Rao, M.S., Srivastava, K., and Puri, S.K., Bioorg. Med. Chem. Lett., 2005, vol. 15, p. 2453.

    Article  CAS  Google Scholar 

  4. Liu, M., Wilairat, P., Croft, S. L., Tan, A. L., and Go, M., Bioorg. Med. Chem., 2003, vol. 11, p. 2729.

    Article  CAS  Google Scholar 

  5. Wu, X., Wilairat, P., and Go, M., Bioorg. Med. Chem. Lett., 2002, vol. 12, p. 2299.

    Article  CAS  Google Scholar 

  6. Ram, V.J., Saxena, A.S., Srivastava, S., and Chandra, S., Bioorg. Med. Chem. Lett., 2000, vol. 10, p. 2159.

    Article  CAS  Google Scholar 

  7. Lin, Y., Zhou, Y., Flavin, M.T., Zhou, L., Nie, W., and Chen, F., Bioorg. Med. Chem., 2002, vol. 10, p. 2795.

    Article  CAS  Google Scholar 

  8. Linga Goud, G., Ramesh, S., Ashok, D., and Prabhakar Reddy, V., Russ. J. Gen. Chem., 2015, vol. 85, p. 673.

    Article  CAS  Google Scholar 

  9. Ramesh, S., Ashok, D., Linga Goud, G., and Prabhakar Reddy, V., Russ. J. Gen. Chem., 2014, vol. 84, p. 1608.

    Article  CAS  Google Scholar 

  10. Ashok, D., Mohan Gandhi, D., Srinivas, G., and Vikas Kumar, A., Med. Chem. Res., 2014, vol. 23, p. 3005.

    Article  CAS  Google Scholar 

  11. Ashok, D., Hanumantha Rao, V., and Sreenivas, P., Heterocycl. Commun., 2013, vol. 19(5), p. 363.

    Article  CAS  Google Scholar 

  12. Wu, J., Wang, X., Yi, Y., and Lee, K., Bioorg. Med. Chem. Lett., 2003, vol. 13, p. 1813.

    Article  CAS  Google Scholar 

  13. Maria, K., Dimitra, H.L., and Maria, G., Med. Chem., 2008, vol. 4, p. 586.

    Article  CAS  Google Scholar 

  14. Ashok, D., Sudershan, K., and Khalilullah, M., Green Chem. Lett. Rev., 2012, vol. 5(2), p. 121.

    Article  CAS  Google Scholar 

  15. Richardson, S.K., Jeganathan, A., Mani, R.S., Haley, B.E., Watt, D.S., and Trusal, L.R., Tetrahedron, 1987, vol. 43, p. 2925.

    Article  CAS  Google Scholar 

  16. Rostovtsev, V.V., Green, L.G., Fokin, V.V., and Sharpless, K.B., Angew. Chem., Int. Ed. 2002, vol. 41, p. 2596.

    Article  CAS  Google Scholar 

  17. Karabulut, H.R.F., and Kac-an, M., Turk. J. Chem., 2003, vol. 27, p. 713.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Green and Medicinal Chemistry Lab, Department of Chemistry, Osmania University, Hyderabad, 500007, India

    G. Linga Goud, S. Ramesh, D. Ashok & V. Prabhakar Reddy

Authors
  1. G. Linga Goud
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  2. S. Ramesh
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  3. D. Ashok
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  4. V. Prabhakar Reddy
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Correspondence to G. Linga Goud.

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The text was submitted by the authors in English.

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Linga Goud, G., Ramesh, S., Ashok, D. et al. Green synthesis and antibacterial evaluation of some new 1-aryl-3-(1-aryl-1H-[1,2,3]triazol-4-yl)-propenones. Russ J Gen Chem 86, 1419–1423 (2016). https://doi.org/10.1134/S1070363216060293

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  • DOI: https://doi.org/10.1134/S1070363216060293

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