Abstract
Objective: This chapter reviews scientific information related to urinary biomarkers of oxidative stress assessed in a firefighting context and their potential for being used in future biomonitoring studies. Background: Firefighters are exposed to several hazard chemicals and physical and mentally-demanding activities than can disrupt body homeostasis. Oxidative stress results from a disequilibrium in oxidation/reduction reactions which can mainly lead to lipid peroxidation and DNA oxidation. There are several urinary biomarkers that can be used for biomonitoring of oxidative stress (e.g., isoprostane, malondialdehyde, and oxidized guanine species). Method: Literature data until April 2021 were retrieved from the main scientific databases and thoroughly analyzed. Results: Information is scarce and available studies have only considered so far wildland firefighting (wildland fires and prescribed burns), with no significant cross-shift changes in lipid peroxidation biomarkers. However, the DNA oxidation biomarker, 8-hydroxy-2’-deoxyguanosine significantly increased in wildland firefighters after exposure to fire emissions. In addition, data are needed to understand the impact of structural firefighting in 8-isoprostane and malondialdehyde urinary levels. Conclusion: Even though there are few studies exploring urinary biomarkers of oxidative stress, they present the potential to be applied in cross-sectional and cohort studies in several types of firefighters. Application: Firefighters’ health monitoring and occupational medicine.
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This work was supported by UIDB/50006/2020, UIDP/50006/2020, and projects PCIF/ SSO/0017/2018 and PCIF/SSO/0090/2019 by Fundação para a Ciência e a Tecnologia through national funds. M. Oliveira and B. Barros thank to the CEEC Program Contract CEECIND/03666/2017 and the grant 2020.07394.BD, respectively.
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Barros, B., Oliveira, M., Morais, S. (2022). Insight into the Potential of Urinary Biomarkers of Oxidative Stress for Firefighters’ Health Surveillance. In: Arezes, P.M., et al. Occupational and Environmental Safety and Health III. Studies in Systems, Decision and Control, vol 406. Springer, Cham. https://doi.org/10.1007/978-3-030-89617-1_29
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