| Verfasst von: | Canney, Mark [VerfasserIn] |
|---|---|
| Induruwage, Dilshani [VerfasserIn] | |
| Tang, Mila [VerfasserIn] | |
| Alencar de Pinho, Natalia [VerfasserIn] | |
| Er, Lee [VerfasserIn] | |
| Zhao, Yinshan [VerfasserIn] | |
| Djurdjev, Ognjenka [VerfasserIn] | |
| Ahn, Yo Han [VerfasserIn] | |
| Behnisch, Rouven [VerfasserIn] | |
| Calice-Silva, Viviane [VerfasserIn] | |
| Chesnaye, Nicholas C. [VerfasserIn] | |
| de Borst, Martin H. [VerfasserIn] | |
| Dember, Laura M. [VerfasserIn] | |
| Dionne, Janis [VerfasserIn] | |
| Ebert, Natalie [VerfasserIn] | |
| Eder, Susanne [VerfasserIn] | |
| Fenton, Anthony [VerfasserIn] | |
| Fukagawa, Masafumi [VerfasserIn] | |
| Furth, Susan L. [VerfasserIn] | |
| Hoy, Wendy E. [VerfasserIn] | |
| Imaizumi, Takahiro [VerfasserIn] | |
| Jager, Kitty J. [VerfasserIn] | |
| Jha, Vivekanand [VerfasserIn] | |
| Kang, Hee Gyung [VerfasserIn] | |
| Kitiyakara, Chagriya [VerfasserIn] | |
| Mayer, Gert [VerfasserIn] | |
| Oh, Kook-Hwan [VerfasserIn] | |
| Onu, Ugochi [VerfasserIn] | |
| Pecoits-Filho, Roberto [VerfasserIn] | |
| Reichel, Helmut [VerfasserIn] | |
| Richards, Anna [VerfasserIn] | |
| Schaefer, Franz [VerfasserIn] | |
| Schaeffner, Elke [VerfasserIn] | |
| Scheppach, Johannes B. [VerfasserIn] | |
| Sola, Laura [VerfasserIn] | |
| Ulasi, Ifeoma [VerfasserIn] | |
| Wang, Jinwei [VerfasserIn] | |
| Yadav, Ashok K. [VerfasserIn] | |
| Zhang, Jianzhen [VerfasserIn] | |
| Feldman, Harold I. [VerfasserIn] | |
| Taal, Maarten W. [VerfasserIn] | |
| Stengel, Bénédicte [VerfasserIn] | |
| Levin, Adeera [VerfasserIn] | |
| Titel: | Regional variation in hemoglobin distribution among individuals with CKD |
| Titelzusatz: | the ISN International Network of CKD Cohorts |
| Verf.angabe: | Mark Canney, Dilshani Induruwage, Mila Tang, Natalia Alencar de Pinho, Lee Er, Yinshan Zhao, Ognjenka Djurdjev, Yo Han Ahn, Rouven Behnisch, Viviane Calice-Silva, Nicholas C. Chesnaye, Martin H. de Borst, Laura M. Dember, Janis Dionne, Natalie Ebert, Susanne Eder, Anthony Fenton, Masafumi Fukagawa, Susan L. Furth, Wendy E. Hoy, Takahiro Imaizumi, Kitty J. Jager, Vivekanand Jha, Hee Gyung Kang, Chagriya Kitiyakara, Gert Mayer, Kook-Hwan Oh, Ugochi Onu, Roberto Pecoits-Filho, Helmut Reichel, Anna Richards, Franz Schaefer, Elke Schaeffner, Johannes B. Scheppach, Laura Sola, Ifeoma Ulasi, Jinwei Wang, Ashok K. Yadav, Jianzhen Zhang, Harold I. Feldman, Maarten W. Taal, Bénédicte Stengel, Adeera Levin, and on behalf of the SN iNET-CKD Investigators |
| E-Jahr: | 2023 |
| Jahr: | 12 August 2023 |
| Umfang: | 12 S. |
| Illustrationen: | Illustrationen |
| Fussnoten: | Gesehen am 05.11.2024 |
| Titel Quelle: | Enthalten in: Kidney international. Reports |
| Ort Quelle: | Amsterdam : Elsevier, 2016 |
| Jahr Quelle: | 2023 |
| Band/Heft Quelle: | 8(2023), 10 vom: Okt., Seite 2056-2067 |
| ISSN Quelle: | 2468-0249 |
| Abstract: | INTRODUCTION: Despite recognized geographic and sex-based differences in hemoglobin in the general population, these factors are typically ignored in patients with chronic kidney disease (CKD) in whom a single therapeutic range for hemoglobin is recommended. We sought to compare the distribution of hemoglobin across international nondialysis CKD populations and evaluate predictors of hemoglobin. - METHODS: In this cross-sectional study, hemoglobin distribution was evaluated in each cohort overall and stratified by sex and estimated glomerular filtration rate (eGFR). Relationships between candidate predictors and hemoglobin were assessed from linear regression models in each cohort. Estimates were subsequently pooled in a random effects model. - RESULTS: A total of 58,613 participants from 21 adult cohorts (median eGFR range of 17-49 ml/min) and 3 pediatric cohorts (median eGFR range of 26-45 ml/min) were included with broad geographic representation. Hemoglobin values varied substantially among the cohorts, overall and within eGFR categories, with particularly low mean hemoglobin observed in women from Asian and African cohorts. Across the eGFR range, women had a lower hemoglobin compared to men, even at an eGFR of 15 ml/min (mean difference 5.3 g/l, 95% confidence interval [CI] 3.7-6.9). Lower eGFR, female sex, older age, lower body mass index, and diabetic kidney disease were all independent predictors of a lower hemoglobin value; however, this only explained a minority of variance (R2 7%-44% across cohorts). - CONCLUSION: There are substantial regional differences in hemoglobin distribution among individuals with CKD, and the majority of variance is unexplained by demographics, eGFR, or comorbidities. These findings call for a renewed interest in improving our understanding of hemoglobin determinants in specific CKD populations. |
| DOI: | doi:10.1016/j.ekir.2023.07.032 |
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.1016/j.ekir.2023.07.032 |
| DOI: https://doi.org/10.1016/j.ekir.2023.07.032 | |
| Datenträger: | Online-Ressource |
| Sprache: | eng |
| Sach-SW: | anemia |
| chronic kidney disease | |
| geography | |
| glomerular filtration rate | |
| hemoglobin | |
| sex | |
| K10plus-PPN: | 1907603379 |
| Verknüpfungen: | → Zeitschrift |