Online-Ressource | |
Verfasst von: | Wannhoff, Andreas [VerfasserIn] |
Wenz, Theresa [VerfasserIn] | |
Weiss, Celine [VerfasserIn] | |
Friedrich, Kilian [VerfasserIn] | |
Rupp, Christian [VerfasserIn] | |
Antoni, Christoph Helmer [VerfasserIn] | |
Stampfl, Ulrike [VerfasserIn] | |
Schemmer, Peter [VerfasserIn] | |
Stremmel, Wolfgang [VerfasserIn] | |
Weiss, Karl Heinz [VerfasserIn] | |
Radeleff, Boris [VerfasserIn] | |
Katus, Hugo [VerfasserIn] | |
Gotthardt, Daniel [VerfasserIn] | |
Titel: | Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt |
Verf.angabe: | A. Wannhoff, T. Hippchen, C.S. Weiss, K. Friedrich, C. Rupp, C. Neumann‐Haefelin, M. Dollinger, C. Antoni, U. Stampfl, P. Schemmer, W. Stremmel, K.H. Weiss, B. Radeleff, H.A. Katus and D.N. Gotthardt |
E-Jahr: | 2016 |
Jahr: | 26 February 2016 |
Umfang: | 11 S. |
Fussnoten: | Gesehen am 21.05.2019 |
Titel Quelle: | Enthalten in: Alimentary pharmacology & therapeutics |
Ort Quelle: | Oxford : Blackwell Science, 1987 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 43(2016), 9, Seite 955-965 |
ISSN Quelle: | 1365-2036 |
Abstract: | Background Transjugular intrahepatic portosystemic shunt (TIPSS) cause haemodynamic changes in patients with cirrhosis, yet little is known about long-term cardiopulmonary outcomes. Aim To evaluate the long-term cardiopulmonary outcome after TIPSS. Methods We evaluated cardiopulmonary parameters including echocardiography during long-term follow-up after TIPSS. Results at 1-5 years after TIPSS were compared to those of cirrhotic controls. Pulmonary hypertension (PH) diagnoses rates were included. Endothelin 1, thromboxane B2 and serotonin were measured. Results We found significant differences 1-5 years after TIPSS compared to pre-implantation values: median left atrial diameter (LAD) increased from 37 mm [interquartile range (IQR): 33-43] to 40 mm (IQR: 37-47, P = 0.001), left ventricular end-diastolic diameter (LV-EDD) increased from 45 mm (range: 41-49) to 48 mm (IQR: 45-52, P < 0.001), pulmonary artery systolic pressure (PASP) increased from 25 mmHg (IQR: 22-33) to 30 mmHg (IQR: 25-36, P = 0.038). Comparing results 1-5 years post-implantation to the comparison cohort revealed significantly higher (P < 0.05) LAD, LV-EDD and PASP values in TIPSS patients. PH prevalence was higher in the shunt group (4.43%) compared to controls (0.91%, P = 0.150). Thromboxane B2 levels correlated with PASP in the TIPSS cohort (P = 0.033). There was no transhepatic gradient observed for the vasoactive substances analysed. Conclusions TIPSS placement is accompanied by long-term cardiovascular changes, including cardiac volume overload, and is associated with an increased rate of pulmonary hypertension. The need for regular cardiac follow-up after TIPSS requires further evaluation. |
DOI: | doi:10.1111/apt.13569 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext ; Verlag: https://doi.org/10.1111/apt.13569 |
Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.13569 | |
DOI: https://doi.org/10.1111/apt.13569 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1665999667 |
Verknüpfungen: | → Zeitschrift |