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Verfasst von:Wannhoff, Andreas [VerfasserIn]   i
 Wenz, Theresa [VerfasserIn]   i
 Weiss, Celine [VerfasserIn]   i
 Friedrich, Kilian [VerfasserIn]   i
 Rupp, Christian [VerfasserIn]   i
 Antoni, Christoph Helmer [VerfasserIn]   i
 Stampfl, Ulrike [VerfasserIn]   i
 Schemmer, Peter [VerfasserIn]   i
 Stremmel, Wolfgang [VerfasserIn]   i
 Weiss, Karl Heinz [VerfasserIn]   i
 Radeleff, Boris [VerfasserIn]   i
 Katus, Hugo [VerfasserIn]   i
 Gotthardt, Daniel [VerfasserIn]   i
Titel:Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt
Verf.angabe:A. Wannhoff, T. Hippchen, C.S. Weiss, K. Friedrich, C. Rupp, C. Neumann‐Haefelin, M. Dollinger, C. Antoni, U. Stampfl, P. Schemmer, W. Stremmel, K.H. Weiss, B. Radeleff, H.A. Katus and D.N. Gotthardt
E-Jahr:2016
Jahr:26 February 2016
Umfang:11 S.
Fussnoten:Gesehen am 21.05.2019
Titel Quelle:Enthalten in: Alimentary pharmacology & therapeutics
Ort Quelle:Oxford : Blackwell Science, 1987
Jahr Quelle:2016
Band/Heft Quelle:43(2016), 9, Seite 955-965
ISSN Quelle:1365-2036
Abstract:Background Transjugular intrahepatic portosystemic shunt (TIPSS) cause haemodynamic changes in patients with cirrhosis, yet little is known about long-term cardiopulmonary outcomes. Aim To evaluate the long-term cardiopulmonary outcome after TIPSS. Methods We evaluated cardiopulmonary parameters including echocardiography during long-term follow-up after TIPSS. Results at 1-5 years after TIPSS were compared to those of cirrhotic controls. Pulmonary hypertension (PH) diagnoses rates were included. Endothelin 1, thromboxane B2 and serotonin were measured. Results We found significant differences 1-5 years after TIPSS compared to pre-implantation values: median left atrial diameter (LAD) increased from 37 mm [interquartile range (IQR): 33-43] to 40 mm (IQR: 37-47, P = 0.001), left ventricular end-diastolic diameter (LV-EDD) increased from 45 mm (range: 41-49) to 48 mm (IQR: 45-52, P < 0.001), pulmonary artery systolic pressure (PASP) increased from 25 mmHg (IQR: 22-33) to 30 mmHg (IQR: 25-36, P = 0.038). Comparing results 1-5 years post-implantation to the comparison cohort revealed significantly higher (P < 0.05) LAD, LV-EDD and PASP values in TIPSS patients. PH prevalence was higher in the shunt group (4.43%) compared to controls (0.91%, P = 0.150). Thromboxane B2 levels correlated with PASP in the TIPSS cohort (P = 0.033). There was no transhepatic gradient observed for the vasoactive substances analysed. Conclusions TIPSS placement is accompanied by long-term cardiovascular changes, including cardiac volume overload, and is associated with an increased rate of pulmonary hypertension. The need for regular cardiac follow-up after TIPSS requires further evaluation.
DOI:doi:10.1111/apt.13569
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1111/apt.13569
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.13569
 DOI: https://doi.org/10.1111/apt.13569
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1665999667
Verknüpfungen:→ Zeitschrift

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