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October 2024

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Healthy eating is not straightforward for consumers, who need to weigh up mixed messaging from health warnings in the media and from persuasive food marketing campaigns. Ultra-processed foods (UPFs) have found themselves at the center of a growing storm, with the mainstream media regularly highlighting increased health risks of consuming UPFs. In this Editorial on behalf of the PLOS Medicine Editors, Alexandra Tosun discusses why UPFs are now a topic of increasing attention, from the attention-grabbing headlines to the underlying nutritional debates. The piece explores the complexities of nutrition research, the influence of the media, and the need for stakeholders across sectors to be held to more rigorous standards.

Image Credit: Images by cottonbro studio, Pexels; Daniel Albany, Sofia Terzoni, Pixabay

Editorial

Manufactured meals: The challenges of ultraprocessed foods

Alexandra Tosun, on behalf of the PLOS Medicine Editors

PLOS Medicine: published October 15, 2024 | https://doi.org/10.1371/journal.pmed.1004477

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Perspectives

Ultraprocessed food (UPF), health, and mechanistic uncertainty: What should we be advising the public to do about UPFs?

Eric Robinson, Alexandra M. Johnstone

PLOS Medicine: published October 15, 2024 | https://doi.org/10.1371/journal.pmed.1004439

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Leveraging behavioral economics strategies to close gaps in biomedical HIV prevention

Jesse Heitner, Valerian Mwenda, Grace Umutesi, Ruanne V. Barnabas

PLOS Medicine: published October 24, 2024 | https://doi.org/10.1371/journal.pmed.1004475

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Research Articles

The incidence of postoperative periprosthetic femoral fracture following total hip replacement: An analysis of UK National Joint Registry and Hospital Episodes statistics data

Jonathan Nicholas Lamb, Jonathan Thomas Evans, Samuel Relton, Michael Richard Whitehouse, J Mark Wilkinson, Hemant Pandit

PLOS Medicine: published October 1, 2024 | https://doi.org/10.1371/journal.pmed.1004462

Estimating the risk and spatial spread of measles in populations with high MMR uptake: Using school-household networks to understand the 2013 to 2014 outbreak in the Netherlands

James D. Munday, Katherine E. Atkins, Don Klinkenberg, Marc Meurs, Erik Fleur, Susan JM Hahné, Jacco Wallinga, Albert Jan van Hoek

PLOS Medicine: published October 8, 2024 | https://doi.org/10.1371/journal.pmed.1004466

Cost-effectiveness of a patient-reported outcome-based remote monitoring and alert intervention for early detection of critical recovery after joint replacement: A randomised controlled trial

Lukas Schöner, David Kuklinski, Laura Wittich, Viktoria Steinbeck, Benedikt Langenberger, Thorben Breitkreuz, Felix Compes, Mathias Kretzler, Ursula Marschall, Wolfgang Klauser, Mustafa Citak, Georg Matziolis, Daniel Schrednitzki, Kim Grasböck, Justus Vogel, Christoph Pross, Reinhard Busse, Alexander Geissler

PLOS Medicine: published October 9, 2024 | https://doi.org/10.1371/journal.pmed.1004459

Growth, physical, and cognitive function in children who are born HIV-free: School-age follow-up of a cluster-randomised trial in rural Zimbabwe

Joe D Piper, Clever Mazhanga, Marian Mwapaura, Gloria Mapako, Idah Mapurisa, Tsitsi Mashedze, Eunice Munyama, Maria Kuona, Thombizodwa Mashiri, Kundai Sibanda, Dzidzai Matemavi, Monica Tichagwa, Soneni Nyoni, Asinje Saidi, Manasa Mangwende, Dzivaidzo Chidhanguro, Eddington Mpofu, Joice Tome, Gabriel Mbewe, Batsirai Mutasa, Bernard Chasekwa, Handrea Njovo, Chandiwana Nyachowe, Mary Muchekeza, Kuda Mutasa, Virginia Sauramba, Ceri Evans, Melissa J Gladstone, Jonathan C Wells, Elizabeth Allen, Melanie Smuk, Jean H Humphrey, Lisa F Langhaug, Naume V Tavengwa, Robert Ntozini, Andrew J Prendergast

PLOS Medicine: published October 11, 2024 | https://doi.org/10.1371/journal.pmed.1004347

Risk of common psychiatric disorders, suicidal behaviours, and premature mortality following violent victimisation: A matched cohort and sibling-comparison study of 127,628 people who experienced violence in Finland and Sweden

Amir Sariaslan, Joonas Pitkänen, Jonas Forsman, Ralf Kuja-Halkola, Isabell Brikell, Brian M. D’Onofrio, Mikko Aaltonen, Henrik Larsson, Pekka Martikainen, Paul Lichtenstein, Seena Fazel

PLOS Medicine: published October 18, 2024 | https://doi.org/10.1371/journal.pmed.1004410

Safety of single-dose bedaquiline combined with rifampicin for leprosy post-exposure prophylaxis: A Phase 2 randomized non-inferiority trial in the Comoros Islands

Bouke Catherine de Jong, Said Nourdine, Auke Thomas Bergeman, Zahara Salim, Silahi Halifa Grillone, Sofie Marijke Braet, Mohamed Wirdane Abdou, Rian Snijders, Maya Ronse, Carolien Hoof, Achilleas Tsoumanis, Nimer Ortuño-Gutiérrez, Christian van der Werf, Alberto Piubello, Aboubacar Mzembaba, Younoussa Assoumani, Epco Hasker

PLOS Medicine: published October 21, 2024 | https://doi.org/10.1371/journal.pmed.1004453

Medical imaging utilization in migrants compared with nonmigrants in a universal healthcare system: A population-based matched cohort study

Giancarlo Di Giuseppe, Rinku Sutradhar, Priscila Pequeno, Marilyn L. Kwan, Diana L. Miglioretti, Rebecca Smith-Bindman, Jason D. Pole

PLOS Medicine: published October 22, 2024 | https://doi.org/10.1371/journal.pmed.1004474

Adverse health outcomes in offspring of parents with alcohol-related liver disease: Nationwide Danish cohort study

Peter Jepsen, Joe West, Anna Kirstine Kjær Larsen, Anna Emilie Kann, Frederik Kraglund, Joanne R. Morling, Colin Crooks, Gro Askgaard

PLOS Medicine: published October 23, 2024 | https://doi.org/10.1371/journal.pmed.1004483

The effect of protecting women against economic shocks to fight HIV in Cameroon, Africa: The POWER randomised controlled trial

Aurélia Lépine, Sandie Szawlowski, Emile Nitcheu, Henry Cust, Eric Defo Tamgno, Julienne Noo, Fanny Procureur, Illiasou Mfochive, Serge Billong, Ubald Tamoufe

PLOS Medicine: published October 24, 2024 | https://doi.org/10.1371/journal.pmed.1004355

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Incidence rates of hepatocellular carcinoma based on risk stratification in steatotic liver disease for precision medicine: A real-world longitudinal nationwide study

Rongtao Lai, Scott Barnett, Xinrong Zhang, Leslie Yeeman Kam, Ramsey Cheung, Qing Xie, Mindie H. Nguyen

PLOS Medicine: published October 25, 2024 | https://doi.org/10.1371/journal.pmed.1004479

Safety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial

Steven Perrin, Shafeeq Ladha, Nicholas Maragakis, Michael H. Rivner, Jonathan Katz, Angela Genge, Nicholas Olney, Dale Lange, Daragh Heitzman, Cynthia Bodkin, Omar Jawdat, Namita A. Goyal, Jeffrey D. Bornstein, Carmen Mak, Stanley H. Appel, Sabrina Paganoni

PLOS Medicine: published October 31, 2024 | https://doi.org/10.1371/journal.pmed.1004469