Scaffold protein JLP is critical for CD40 signaling in B lymphocytes
H Wang, Q Yan, T Yang, H Cheng, J Du… - Journal of Biological …, 2015 - ASBMB
CD40 expression on the surface of B lymphocytes is essential for their biological function
and fate decision. The engagement of CD40 with its cognate ligand, CD154, leads to a
sequence of cellular events in B lymphocytes, including CD40 cytoplasmic translocation, a
temporal and spatial organization of effector molecules, and a cascade of CD40-induced
signal transduction. The JLP scaffold protein was expressed in murine B lymphocytes. Using
B lymphocytes from jlp-deficient mice, we observed that JLP deficiency resulted in defective …
and fate decision. The engagement of CD40 with its cognate ligand, CD154, leads to a
sequence of cellular events in B lymphocytes, including CD40 cytoplasmic translocation, a
temporal and spatial organization of effector molecules, and a cascade of CD40-induced
signal transduction. The JLP scaffold protein was expressed in murine B lymphocytes. Using
B lymphocytes from jlp-deficient mice, we observed that JLP deficiency resulted in defective …