Background The TRPA1 ion channel modulates excitability of nociceptors, and it may be
activated by compounds resulting from oxidative insults. Diabetes mellitus produces
oxidative stress and sensory neuropathy. The authors tested the hypothesis that diabetes-
induced endogenous compounds acting on the TRPA1 ion channel contribute to
development and maintenance of mechanical hypersensitivity. Methods Diabetes mellitus
was induced by streptozotocin. Mechanical hypersensitivity was assessed by the …