i am academic person in pharmaceutics department and very enthusiastic person in dealing research work, which is quietly related to pharmaceutics field. Address: India
Objective: The objective of this study was to formulate an oral sustained release delivery system... more Objective: The objective of this study was to formulate an oral sustained release delivery system of ezetimibe mucoadhesive beads by ionic gelation technique based on sodium alginate used as a hydrophilic carrier in combination with carbopol 934P which acts as a rate modifier. Methods: Microbeads of ezetimibe were prepared using an easy method of ionotropic gelation by little modification while in addition of drug. The prepared beads were characterised for mean particle size, entrapment efficiency, swelling capacity, and in vitro release. They were also subjected to various studies such as Fourier Transform Infrared Spectrophotometer (FTIR) Spectroscopy for drug polymer reaction, Scanning Electron Microscopy for surface morphology, and Differential Scanning Calorimetric Analysis to determine the physical state of the drug in the beads. Results: The microspheres of ezetimibe were formulated successfully. The addition of drug concentration gives higher drug loading and higher conc. of Alcl+3 Conclusion: It can be concluded that beads produced by the sequential method had higher drug entrapment. Beads produced by simultaneous yields larger beads in diameter. The concept was cleared that drug release was dependent upon the quantity of polymer and increase in conc. of. aluminium chloride retarded the drug release in the sequential method. Prepared beads enhance the dissolution of ezetimibe and the oral bioavailability and also reduce the fluctuations in the oral bioavailability. yields small diameter beads and lower drug entrapment. Analysis of the release profiles showed that the data corresponds to zero order release and the diffusion-controlled mechanism as suggested by Higuchi concept. INTRODUCTION Controlled release systems have been extensively developed and advised to superior due to their extensive therapeutic advantages over conventional forms [1]. The current article was aimed to develop a sustained release dosage form of ezetimibe using a natural, biodegradable polymeric carrier sodium alginate for oral dosage form. The versatility of polymeric materials allows ease fabrication of the drug delivery devices with a desirable degree of swelling and consequently of the release of the drug. This microparticulate material as in the form of microbeads may be dispensed as filled in hard gelatin capsules or they can be compressed into a suitable dosage form like tablets or hard gelatin capsule [2]. The principle of gelation or crosslinking of sodium alginate with aluminium chloride is based on the formation of a tight junction between the guluronic acid residues. The gelation and cross-linking are due to the stacking of the glucuronic acid G blocks of alginate chains with the formation of egg-box junction [3]. The numbers of the apparent cross-linking sites within the formed aluminium alginate gel beads increased with increasing sodium alginate concentration in the formulation. This increase in the apparent crosslinking density delayed the alginate gel disintegration in phosphate buffer due to the retardation of Al+3 exchange with Na +
Objective: The objective of this study was to formulate an oral sustained release delivery system... more Objective: The objective of this study was to formulate an oral sustained release delivery system of ezetimibe mucoadhesive beads by ionic gelation technique based on sodium alginate used as a hydrophilic carrier in combination with carbopol 934P which acts as a rate modifier. Methods: Microbeads of ezetimibe were prepared using an easy method of ionotropic gelation by little modification while in addition of drug. The prepared beads were characterised for mean particle size, entrapment efficiency, swelling capacity, and in vitro release. They were also subjected to various studies such as Fourier Transform Infrared Spectrophotometer (FTIR) Spectroscopy for drug polymer reaction, Scanning Electron Microscopy for surface morphology, and Differential Scanning Calorimetric Analysis to determine the physical state of the drug in the beads. Results: The microspheres of ezetimibe were formulated successfully. The addition of drug concentration gives higher drug loading and higher conc. of Alcl+3 Conclusion: It can be concluded that beads produced by the sequential method had higher drug entrapment. Beads produced by simultaneous yields larger beads in diameter. The concept was cleared that drug release was dependent upon the quantity of polymer and increase in conc. of. aluminium chloride retarded the drug release in the sequential method. Prepared beads enhance the dissolution of ezetimibe and the oral bioavailability and also reduce the fluctuations in the oral bioavailability. yields small diameter beads and lower drug entrapment. Analysis of the release profiles showed that the data corresponds to zero order release and the diffusion-controlled mechanism as suggested by Higuchi concept. INTRODUCTION Controlled release systems have been extensively developed and advised to superior due to their extensive therapeutic advantages over conventional forms [1]. The current article was aimed to develop a sustained release dosage form of ezetimibe using a natural, biodegradable polymeric carrier sodium alginate for oral dosage form. The versatility of polymeric materials allows ease fabrication of the drug delivery devices with a desirable degree of swelling and consequently of the release of the drug. This microparticulate material as in the form of microbeads may be dispensed as filled in hard gelatin capsules or they can be compressed into a suitable dosage form like tablets or hard gelatin capsule [2]. The principle of gelation or crosslinking of sodium alginate with aluminium chloride is based on the formation of a tight junction between the guluronic acid residues. The gelation and cross-linking are due to the stacking of the glucuronic acid G blocks of alginate chains with the formation of egg-box junction [3]. The numbers of the apparent cross-linking sites within the formed aluminium alginate gel beads increased with increasing sodium alginate concentration in the formulation. This increase in the apparent crosslinking density delayed the alginate gel disintegration in phosphate buffer due to the retardation of Al+3 exchange with Na +
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