Papers by Veronique Del Marmol
Dermatology, Jul 25, 2023
Background: Acne conglobata (AC) and nodulocystic acne have long been confused clinically, despit... more Background: Acne conglobata (AC) and nodulocystic acne have long been confused clinically, despite the presentation and the response to treatment being different. AC and hidradenitis suppurativa (HS) resemble each other; a subtype of HS called “conglobata phenotype” has recently been reported in a large Dutch cohort. Acne vulgaris and HS are often associated. Isotretinoin is typically ineffective in treating HS and may even aggravate it, but it is often indispensable in treating acne vulgaris. Objective: The aim of the study was to assess whether isotretinoin may be used safely in adults with both HS and acne vulgaris and when it might be contraindicated. Materials and Methods: Belgian HS patients from the European Registry for Hidradenitis Suppurativa Registry (ERHS) reporting a history of severe acne of the face and/or the back, and who have ever used isotretinoin for their acne, were all selected. Patients whose acne worsened on isotretinoin were compared to patients whose acne did not worsen (improvement or no change). Results: Among the 82 selected patients, 10 (12.2%) report that their acne was aggravated while taking isotretinoin, while 72 (87.8%) report that their acne was not aggravated on isotretinoin. Of the 10 HS patients whose acne worsened with isotretinoin, 9 (90%) were men (p = 0.04) and 8 (80%) were HS “conglobata phenotype” (p < 0.001). In contrast, 47 (65.3%) of the 72 patients whose acne did not worsen on isotretinoin belonged to the HS “regular phenotype” (p = 0.01). On multivariate analysis, the item most strongly associated with poor response to isotretinoin was the HS “conglobata phenotype,” followed by body mass index (BMI) (worse response to isotretinoin if BMI >25 kg/m2). Additionally, of 26 patients who received isotretinoin while their HS had already started, only 6 (23.1%) reported isotretinoin effectiveness on their HS. Conclusion: Subject to confirmation by larger studies, our study suggests that isotretinoin should be avoided in the treatment of acne in HS patients with the HS “conglobata phenotype,” as it may worsen the acne, likewise being male or having a BMI above 25 seems to increase this risk of a bad therapeutic outcome. Patients with an HS “regular phenotype” appear to be at a reduced risk of isotretinoin treatment worsening their acne.
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European Journal of Cancer, Nov 1, 2020
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British Journal of Dermatology, Jul 28, 2019
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The complete physiopathology is still unclear. Two separate processes have been described: a prog... more The complete physiopathology is still unclear. Two separate processes have been described: a progressive calcification of medium and small vessels of the subcutaneous and fat tissues related to an abnormal phosphate/calcium ratio occurring in the presence of predisposing factors (chronic vasculopathy, diabetes mellitus, obesity, renal insufficiency, etc.) and an acute phase caused by a decreased blood flow (hypotension, hemostatis perturbations and coagulopathy, infection, injury, etc.) causing the infarction of the tissues. The main risk factor for calciphylaxis is the chronic renal insufficiency with or without a hyperparathyroidy. It mostly occurs on a dialysed patient but may be also associated with other conditions (corticosteroids or antivitamin K therapy, neoplasia, chronic inflammation, etc.).SCOPUS: ch.binfo:eu-repo/semantics/publishe
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British Journal of Dermatology, Nov 1, 2022
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Case Reports in Dermatology, Jul 12, 2018
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Case Reports in Dermatology, Jan 31, 2018
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European Journal of Dermatology, May 1, 2014
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Dermatology, Dec 19, 2018
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European Journal of Cancer, Sep 1, 2019
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Experimental Dermatology, Nov 3, 2021
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British Journal of Dermatology, 2020
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Journal of The European Academy of Dermatology and Venereology, Aug 24, 2020
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British Journal of Dermatology, Dec 8, 2010
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Journal of The European Academy of Dermatology and Venereology, Jun 26, 2020
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Science Advances, Jan 10, 2020
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Dermatology Practical & Conceptual
Introduction: Melanoma of the lentigo maligna (LM) type is challenging. There is lack of consensu... more Introduction: Melanoma of the lentigo maligna (LM) type is challenging. There is lack of consensus on the optimal diagnosis, treatment, and follow-up. Objectives: To obtain general consensus on the diagnosis, treatment, and follow-up for LM. Methods: A modified Delphi method was used. The invited participants were either members of the International Dermoscopy Society, academic experts, or authors of published articles relating to skin cancer and melanoma. Participants were required to respond across three rounds using a 4-point Likert scale). Consensus was defined as >75% of participants agreeing/strongly agreeing or disagreeing/strongly disagreeing. Results: Of the 31 experts invited to participate in this Delphi study, 29 participants completed Round 1 (89.9% response rate), 25/31 completed Round 2 (77.5% response rate), and 25/31 completed Round 3 (77.5% response rate). Experts agreed that LM diagnosis should be based on a clinical and dermatoscopic approach (92%) followed by...
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Clinical and Experimental Dermatology
Background Ultrasound imaging has recently benefited from the introduction of a new 70 MHz transd... more Background Ultrasound imaging has recently benefited from the introduction of a new 70 MHz transducer able to provide high-resolution images, i.e. ultra-high-frequency ultrasound (UHFUS). Aim To study the morphological features of basal cell carcinomas (BCCs) and measure BCC thickness by means of UHFUS examination. Methods In this retrospective multicentric study, 171 consecutive patients underwent UHFUS examination between November 2018 and May 2019 for suspected BCC. Diagnosis was confirmed by histopathology. A series of morphological parameters including echogenicity, structure, borders, shape composition (presence of intralesional structures) were investigated along with objective measurements such as thickness (maximum distance between the surface of the epidermis and the deepest part of the tumour) and width. Results In total, 117 BCCs from 93 patients were examined, including superficial (n = 13; 11.1%), nodular (n = 64; 54.7%), infiltrative (n = 18; 15.4%), mixed subtypes (n...
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Clinical and Experimental Dermatology
Background Line-field confocal optical coherence tomography (LC-OCT) is a new in vivo emerging te... more Background Line-field confocal optical coherence tomography (LC-OCT) is a new in vivo emerging technique that provides cellular resolution, allows deep imaging (400 μm) and produces real-time images in both the horizontal and vertical plane and in three dimensions. No previous description of different subtypes of melanocytic lesions and their correlation with histopathology and reflectance confocal microscopy has been reported. Aim To describe the features of melanocytic lesions by LC-OCT and their correlation with histopathology and reflectance confocal microscopy (RCM) findings. Methods Selected melanocytic benign lesions and melanomas were imaged in vivo with RCM and LC-OCT at the Fundación Hospital Clinic (Barcelona, Spain). A minimum area of 4 × 4 mm (block image) at four depths (stratum granulosum, suprabasal, layer dermoepidermal junction and upper dermis) were acquired with RCM and a minimum of three cubes with LC-OCT. Horizontal, vertical sections and three-dimensional (3D)...
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Photonics in Dermatology and Plastic Surgery 2019, 2019
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Papers by Veronique Del Marmol