Purpose The purpose of this study was to assess patient satisfaction and identify risk factors fo... more Purpose The purpose of this study was to assess patient satisfaction and identify risk factors for dissatisfaction after anterior stabilised conventional total knee arthroplasty (TKA) without patellar resurfacing, using the Goodman score. Methods We conducted a cross-sectional study using data from our institutional database from 1 January 2018 to 1 March 2021. Patients who underwent TKA with the Vanguard® Cruciate Retaining Anterior Stabilized Knee System (Zimmer Biomet, Warsaw, Indiana, USA) without patellar replacement were invited to participate. Patients with other bearing surfaces (posterior stabilised or medial congruent) or diagnosed with infection or instability were excluded. Patients' reported outcomes, body mass index (BMI), passive range of motion, the timed up-and-go test, sit-up test, and algometry were assessed. Patients were also asked if they had anterior knee pain. Satisfaction was assessed using the Goodman scale, and logistic multivariate regression was used...
Biological processes are intrinsically noisy and yet, the result of development --like the specie... more Biological processes are intrinsically noisy and yet, the result of development --like the species-specific size and shape of organs-- is usually remarkably precise. This precision suggests the existence of mechanisms of feedback control that ensure that deviations from a target size are minimized. Still, we have very limited understanding of how these mechanisms operate. Here, we investigate the problem of organ size precision using theDrosophilaeye. The size of the adult eye depends on the rates at which eye progenitor cells grow and differentiate. We first find that the progenitor net growth rate results from the balance between their proliferation and apoptosis, with this latter contributing to determining both final eye size and its variability. In turn, apoptosis of progenitor cells is hampered by Dpp, a BMP2/4 signaling molecule transiently produced by early differentiating retinal cells. Our genetic and computational experiments show how the status of retinal differentiation...
2019 IEEE International Conference on Space Optical Systems and Applications (ICSOS)
Optical communication technologies offer unprecedented transmission data rates, resilience and da... more Optical communication technologies offer unprecedented transmission data rates, resilience and data security to satellite communications. ESA and its member states have successfully introduced optical communication technologies in the European Data Relay System (EDRS), providing commercial Quasi-Real-Time-Data service to the European Commission Copernicus satellite fleet (Sentinel-1A/B, Sentinels-2A/B). The EDRS / SpaceDataHighway has already provided more than 25.000 successful links since start of operations in 2016, resulting in an availability of >99.5%, [1], [2]. Nonetheless, full capabilities of optical technologies cannot be fully exploited, because these optical payloads are mainly used in non-optimized SatCom systems. In response, a dedicated programme for Optical Communication Technologies was created in 2016 by ESA called "ScyLight" (SeCure and Laser communication Technology). Furthermore, to address the system level aspects for the massive introduction of optical / photonic technologies in SatCom systems, ESA has recently launched several internal and external initiatives in preparation of an innovative project proposal called HydRON (High Throughput Optical Network), [3]. In HydRON, optical interconnections in the Tbps regime (Terabit per second) are envisaged including "All-Optical payloads" furnishing the "bridges" for a truly "Fibre in Space" network, as shown in Figure 5. Technically speaking HydRON aims at Tbps "All-Optical Network" solutions, dividing the satellite payload into (i) a network part and (ii) an application / service part, equivalent to the backbone part and the access part of optical fibre networks on ground. The application / service part (i.e., the RF payload) has access to the network part (i.e., the HydRON elements), in a similar way as computers are connected to the terrestrial network. HydRON will prepare optical feeder links into a network of in-orbit Technology Demonstrators (called HydRON#1, #2, etc.), which will be interconnected by means of Tbps laser intersatellite links. WDM (W avelength Division Multiplexing) laser communication terminals (on ground and in space), and optical switching / routing capabilities on-board the network nodes in space will be implemented together with optical payloads to enable a high throughput network connection to the application / service part (i.e., the RF payload). The space network concept will reduce the dependency on single ground stations as all HydRON nodes will get their particular data via the network they are interfacing with. A combination of new optical technologies, novel photonics equipment and efficient network concepts will be proven in orbit. However, the overall network architecture must be optimized for satellite networks. This architecture must be satellite-technology specific and adaptable to the changing network conditions. The ultimate goal is to seamlessly integrate the space optical transport network into the terrestrial high capacity network infrastructure: the "Fibre in the Sky".
Advances in Communications Satellite Systems Proceedings of The 36th International Communications Satellite Systems Conference (ICSSC-2018), 2019
This paper presents the design and performance of a communications payload module equipped with d... more This paper presents the design and performance of a communications payload module equipped with dedicated antennas for K-band, UHF and S-band links, which is envisaged as part of a possible future satellite constellation. The proposed design enables high availability and high capacity digital communication links between the Moon and Earth for a wide range of lunar missions; manned and unmanned, orbiters (including cubesats), landers, sample return vehicles, and includes compatibility to missions such as Lunar Orbital Platform-Gateway and Orion.
Introduction and objectives. Flow-cytometry based automated blood cell counters measure the volum... more Introduction and objectives. Flow-cytometry based automated blood cell counters measure the volume (V), conductivity (C) and light scatter (S) of cells and make available these values for each subpopulation of white blood cells. Although differences in V, C and S among several lymphoproliferative disorders, reactive lymphocytes and normal lymphocytes have been described, the ability to use this this information to detect lymphoproliferative disorders has not been defined. Methods. We registered VCS data of all consecutive cases of lymphocytosis (lymphocytes > 3.5x10e9/l) detected in routine laboratory testing during 50 non-consecutive days. Lymphocytes were evaluated morphologically, immunophenotypically and by conventional cytogenetics if necessary and the patients were evaluated clinically to document diagnosis adequately. Discriminant analisys modelling was used to assess the ability to predict diagnosis of VCS data. Results. 202 cases of lymphocytosis were detected in 120 mal...
The differentiation of tissues and organs requires that cells exchange information in space and t... more The differentiation of tissues and organs requires that cells exchange information in space and time. Spatial information is often conveyed by morphogens, molecules that disperse across receiving cells generating signaling gradients. Cells translate such concentration gradients into space-dependent patterns of gene expression and cellular behavior. But could morphogen gradients also convey developmental time? Here, investigating the developmental role of Hh on a component of the Drosophila visual system, the ocellar retina, we discovered that ocellar cells use the non-linear gradient of Hh as a temporal cue, collectively performing the biological equivalent of a mathematical logarithmic transformation. In this way, a morphogen diffusing from a non-moving source is decoded as a wave of differentiating photoreceptors that travels at constant speed throughout the retinal epithelium.
Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, Jan 3, 2018
Alcohol consumption has been implicated as an important factor driving the demand for medical car... more Alcohol consumption has been implicated as an important factor driving the demand for medical care at mass gatherings. Patients exhibiting signs of possible alcohol intoxication are frequently diverted from traditional medical support facilities located within mass gathering events due to their disruptive behavior or need for prolonged observation. This conventional strategy can place additional stress on Emergency Medical Services (EMS) and Emergency Department (ED) resources. The purpose of this study was to determine if incorporation of an on-site alcohol sobering facility to supplement existing on-site medical support resources was associated with changes in EMS and ED resource utilization during an annual mass gathering. This retrospective observational study of a large, annual mass gathering included prospectively collected data from before and after the deployment of an on-site alcohol sobering facility. One year of EMS data along with 2 years of ED data from the pre-deployme...
2012 IEEE Wireless Communications and Networking Conference (WCNC), 2012
Powered by digital transmission advances in recent years, wireless sensor networks (WSNs) are beg... more Powered by digital transmission advances in recent years, wireless sensor networks (WSNs) are beginning to experience a boom in different areas. Of special interest are those applications offering real-time tracking and monitoring of objects in motion, both indoors and outdoors. A WSN can have a large number of nodes, each with multiple neighbor nodes. These nodes work together to create a self-configuring mesh that can efficiently achieve a common objective. In this paper, we focus on the accuracy of intruder tracking and monitoring, when relying on low-cost binary detection sensing mechanisms. To overcome the limitations imposed by this kind of sensors, we propose an intruder tracking algorithm to estimate the intruder location. In our study, we adopted the IEEE 802.15.4 standard for radio communications, and the MRLG (Mobile-sink Routing for Large Grids) protocol to route data to a mobile sink. Experimental results based on a grid sensor deployment show that the tracking error, measured as the mean euclidean distance between the estimated and the real intruder locations, is typically maintained below 10 meters, validating the applicability of the proposed solution.
Purpose The purpose of this study was to assess patient satisfaction and identify risk factors fo... more Purpose The purpose of this study was to assess patient satisfaction and identify risk factors for dissatisfaction after anterior stabilised conventional total knee arthroplasty (TKA) without patellar resurfacing, using the Goodman score. Methods We conducted a cross-sectional study using data from our institutional database from 1 January 2018 to 1 March 2021. Patients who underwent TKA with the Vanguard® Cruciate Retaining Anterior Stabilized Knee System (Zimmer Biomet, Warsaw, Indiana, USA) without patellar replacement were invited to participate. Patients with other bearing surfaces (posterior stabilised or medial congruent) or diagnosed with infection or instability were excluded. Patients' reported outcomes, body mass index (BMI), passive range of motion, the timed up-and-go test, sit-up test, and algometry were assessed. Patients were also asked if they had anterior knee pain. Satisfaction was assessed using the Goodman scale, and logistic multivariate regression was used...
Biological processes are intrinsically noisy and yet, the result of development --like the specie... more Biological processes are intrinsically noisy and yet, the result of development --like the species-specific size and shape of organs-- is usually remarkably precise. This precision suggests the existence of mechanisms of feedback control that ensure that deviations from a target size are minimized. Still, we have very limited understanding of how these mechanisms operate. Here, we investigate the problem of organ size precision using theDrosophilaeye. The size of the adult eye depends on the rates at which eye progenitor cells grow and differentiate. We first find that the progenitor net growth rate results from the balance between their proliferation and apoptosis, with this latter contributing to determining both final eye size and its variability. In turn, apoptosis of progenitor cells is hampered by Dpp, a BMP2/4 signaling molecule transiently produced by early differentiating retinal cells. Our genetic and computational experiments show how the status of retinal differentiation...
2019 IEEE International Conference on Space Optical Systems and Applications (ICSOS)
Optical communication technologies offer unprecedented transmission data rates, resilience and da... more Optical communication technologies offer unprecedented transmission data rates, resilience and data security to satellite communications. ESA and its member states have successfully introduced optical communication technologies in the European Data Relay System (EDRS), providing commercial Quasi-Real-Time-Data service to the European Commission Copernicus satellite fleet (Sentinel-1A/B, Sentinels-2A/B). The EDRS / SpaceDataHighway has already provided more than 25.000 successful links since start of operations in 2016, resulting in an availability of >99.5%, [1], [2]. Nonetheless, full capabilities of optical technologies cannot be fully exploited, because these optical payloads are mainly used in non-optimized SatCom systems. In response, a dedicated programme for Optical Communication Technologies was created in 2016 by ESA called "ScyLight" (SeCure and Laser communication Technology). Furthermore, to address the system level aspects for the massive introduction of optical / photonic technologies in SatCom systems, ESA has recently launched several internal and external initiatives in preparation of an innovative project proposal called HydRON (High Throughput Optical Network), [3]. In HydRON, optical interconnections in the Tbps regime (Terabit per second) are envisaged including "All-Optical payloads" furnishing the "bridges" for a truly "Fibre in Space" network, as shown in Figure 5. Technically speaking HydRON aims at Tbps "All-Optical Network" solutions, dividing the satellite payload into (i) a network part and (ii) an application / service part, equivalent to the backbone part and the access part of optical fibre networks on ground. The application / service part (i.e., the RF payload) has access to the network part (i.e., the HydRON elements), in a similar way as computers are connected to the terrestrial network. HydRON will prepare optical feeder links into a network of in-orbit Technology Demonstrators (called HydRON#1, #2, etc.), which will be interconnected by means of Tbps laser intersatellite links. WDM (W avelength Division Multiplexing) laser communication terminals (on ground and in space), and optical switching / routing capabilities on-board the network nodes in space will be implemented together with optical payloads to enable a high throughput network connection to the application / service part (i.e., the RF payload). The space network concept will reduce the dependency on single ground stations as all HydRON nodes will get their particular data via the network they are interfacing with. A combination of new optical technologies, novel photonics equipment and efficient network concepts will be proven in orbit. However, the overall network architecture must be optimized for satellite networks. This architecture must be satellite-technology specific and adaptable to the changing network conditions. The ultimate goal is to seamlessly integrate the space optical transport network into the terrestrial high capacity network infrastructure: the "Fibre in the Sky".
Advances in Communications Satellite Systems Proceedings of The 36th International Communications Satellite Systems Conference (ICSSC-2018), 2019
This paper presents the design and performance of a communications payload module equipped with d... more This paper presents the design and performance of a communications payload module equipped with dedicated antennas for K-band, UHF and S-band links, which is envisaged as part of a possible future satellite constellation. The proposed design enables high availability and high capacity digital communication links between the Moon and Earth for a wide range of lunar missions; manned and unmanned, orbiters (including cubesats), landers, sample return vehicles, and includes compatibility to missions such as Lunar Orbital Platform-Gateway and Orion.
Introduction and objectives. Flow-cytometry based automated blood cell counters measure the volum... more Introduction and objectives. Flow-cytometry based automated blood cell counters measure the volume (V), conductivity (C) and light scatter (S) of cells and make available these values for each subpopulation of white blood cells. Although differences in V, C and S among several lymphoproliferative disorders, reactive lymphocytes and normal lymphocytes have been described, the ability to use this this information to detect lymphoproliferative disorders has not been defined. Methods. We registered VCS data of all consecutive cases of lymphocytosis (lymphocytes > 3.5x10e9/l) detected in routine laboratory testing during 50 non-consecutive days. Lymphocytes were evaluated morphologically, immunophenotypically and by conventional cytogenetics if necessary and the patients were evaluated clinically to document diagnosis adequately. Discriminant analisys modelling was used to assess the ability to predict diagnosis of VCS data. Results. 202 cases of lymphocytosis were detected in 120 mal...
The differentiation of tissues and organs requires that cells exchange information in space and t... more The differentiation of tissues and organs requires that cells exchange information in space and time. Spatial information is often conveyed by morphogens, molecules that disperse across receiving cells generating signaling gradients. Cells translate such concentration gradients into space-dependent patterns of gene expression and cellular behavior. But could morphogen gradients also convey developmental time? Here, investigating the developmental role of Hh on a component of the Drosophila visual system, the ocellar retina, we discovered that ocellar cells use the non-linear gradient of Hh as a temporal cue, collectively performing the biological equivalent of a mathematical logarithmic transformation. In this way, a morphogen diffusing from a non-moving source is decoded as a wave of differentiating photoreceptors that travels at constant speed throughout the retinal epithelium.
Prehospital emergency care : official journal of the National Association of EMS Physicians and the National Association of State EMS Directors, Jan 3, 2018
Alcohol consumption has been implicated as an important factor driving the demand for medical car... more Alcohol consumption has been implicated as an important factor driving the demand for medical care at mass gatherings. Patients exhibiting signs of possible alcohol intoxication are frequently diverted from traditional medical support facilities located within mass gathering events due to their disruptive behavior or need for prolonged observation. This conventional strategy can place additional stress on Emergency Medical Services (EMS) and Emergency Department (ED) resources. The purpose of this study was to determine if incorporation of an on-site alcohol sobering facility to supplement existing on-site medical support resources was associated with changes in EMS and ED resource utilization during an annual mass gathering. This retrospective observational study of a large, annual mass gathering included prospectively collected data from before and after the deployment of an on-site alcohol sobering facility. One year of EMS data along with 2 years of ED data from the pre-deployme...
2012 IEEE Wireless Communications and Networking Conference (WCNC), 2012
Powered by digital transmission advances in recent years, wireless sensor networks (WSNs) are beg... more Powered by digital transmission advances in recent years, wireless sensor networks (WSNs) are beginning to experience a boom in different areas. Of special interest are those applications offering real-time tracking and monitoring of objects in motion, both indoors and outdoors. A WSN can have a large number of nodes, each with multiple neighbor nodes. These nodes work together to create a self-configuring mesh that can efficiently achieve a common objective. In this paper, we focus on the accuracy of intruder tracking and monitoring, when relying on low-cost binary detection sensing mechanisms. To overcome the limitations imposed by this kind of sensors, we propose an intruder tracking algorithm to estimate the intruder location. In our study, we adopted the IEEE 802.15.4 standard for radio communications, and the MRLG (Mobile-sink Routing for Large Grids) protocol to route data to a mobile sink. Experimental results based on a grid sensor deployment show that the tracking error, measured as the mean euclidean distance between the estimated and the real intruder locations, is typically maintained below 10 meters, validating the applicability of the proposed solution.
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Papers by Tomas Navarro