Expert evidence in medical imaging claims has the potential for well-recognised biases. Informati... more Expert evidence in medical imaging claims has the potential for well-recognised biases. Informational biases occur from the distorted context when an expert witness knows which specific finding is present and the severity of the injury sustained as a result of the undiagnosed finding. Systemic litigation biases occur from the selection and undersampling of opinions and issues with compensation and affiliation between the expert and parties to litigation. Blinding the expert witness to outcomes holds potential for mitigating these biases and may act as a screening tool to evaluate civil claims. The more complex strategies of blinding the expert to both the legal case and the commissioning legal party, by providing a "library of imaging" for review to imitate a normal day's work, are unlikely to be practical for Australian legal practice. The persuasiveness of blinded expert evidence in mediation, concurrent evidence and court decisions in Australia is still uncertain.
Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prel... more Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prelabour rupture of the membranes, chorioamnionitis, postpartum endometritis and preterm labour and delivery. It is easy to diagnose and treat; intervention reduces the incidence of adverse sequelae. Symptomatic women and those who are at increased risk of infectious morbidity should be screened.
Archives of Gynecology and Obstetrics, Feb 26, 2015
To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (... more To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (FMRI) over the past decade in the diagnosis of anomalies of the corpus callosum in a tertiary referral centre. A single tertiary referral centre ultrasound database was searched for cases of suspected callosal anomalies between 2003 and 2012. All subsequent ultrasound scans, MRIs, neonatal imaging, postmortem investigations and birth records were reviewed. Callosal anomalies were classified into isolated or complex based on the presence or absence of accompanying congenital anomalies. Forty-three cases of callosal anomaly were detected; 60 % were investigated by FMRI revealing additional diagnoses in 23 %; half of which were anomalies of cortical development. Of those considered isolated who underwent FMRI, 21 % were diagnosed with additional anomalies, changing the classification to a complex callosal anomaly. In cases of callosal anomaly suspected on ultrasound, FMRI provides greater certainty and the potential to identify significant additional anomalies. The additional information may alter or clarify prognosis and help parents to better understand the pathology, allowing for informed decisions about the pregnancy to be made. However, some cases may still be diagnosed with additional anomalies after delivery and parents should be aware of such limitations of antenatal imaging.
Methods Hospital ultrasound and MRI databases were searched for cases of suspected callosal anoma... more Methods Hospital ultrasound and MRI databases were searched for cases of suspected callosal anomalies between 2003 and 2012. Subsequent ultrasound scans, fetal MRI, postnatal imaging, postmortem investigations and birth records were reviewed. Fetuses with major additional extracranial anomalies, abnormal karyotype and multiple pregnancies were excluded. Callosal anomalies were classified into isolated or complex based on the presence or absence of accompanying intracranial findings.
Reproductive sciences (Thousand Oaks, Calif.), Jan 16, 2016
Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating w... more Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating women. Development of targeted treatments has been limited by poor understanding of local mechanisms underlying HMB. We aimed to determine how gene expression differs in menstrual phase endometrium from women with HMB. Menstrual phase endometrial biopsies were collected from women with (n = 7) and without (n = 10) HMB (regular menstrual cycles, no known pelvic pathology), as well as women with uterine fibroids (n = 7, n = 4 had HMB). Biopsies were analyzed using Illumina Sentrix Human HT12 arrays and data analyzed using "Remove Unwanted Variation-inverse". Ingenuity Pathway Analysis and the Database for Annotation, Visualization and Integrated Discovery v6.7 were used to identify gene pathways, functional gene clusters, and upstream regulators specific to the clinical groupings. Individual genes of interest were examined using quantitative polymerase chain reaction. In total, 82...
Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prel... more Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prelabour rupture of the membranes, chorioamnionitis, postpartum endometritis and preterm labour and delivery. It is easy to diagnose and treat; intervention reduces the incidence of adverse sequelae. Symptomatic women and those who are at increased risk of infectious morbidity should be screened.
Archives of gynecology and obstetrics, Jan 26, 2015
To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (... more To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (FMRI) over the past decade in the diagnosis of anomalies of the corpus callosum in a tertiary referral centre. A single tertiary referral centre ultrasound database was searched for cases of suspected callosal anomalies between 2003 and 2012. All subsequent ultrasound scans, MRIs, neonatal imaging, postmortem investigations and birth records were reviewed. Callosal anomalies were classified into isolated or complex based on the presence or absence of accompanying congenital anomalies. Forty-three cases of callosal anomaly were detected; 60 % were investigated by FMRI revealing additional diagnoses in 23 %; half of which were anomalies of cortical development. Of those considered isolated who underwent FMRI, 21 % were diagnosed with additional anomalies, changing the classification to a complex callosal anomaly. In cases of callosal anomaly suspected on ultrasound, FMRI provides greater c...
ABSTRACT The ‘standard of care’ for chromosome testing has recently changed. For the last 30 year... more ABSTRACT The ‘standard of care’ for chromosome testing has recently changed. For the last 30 years it has involved chromosome testing using microscope analysis. New technology using ‘DNA chips’, i.e. molecular karyotyping or microarray has now become available and is routinely offered to pregnant women undergoing invasive testing for an ultrasound detected fetal abnormality.
Expert evidence in medical imaging claims has the potential for well-recognised biases. Informati... more Expert evidence in medical imaging claims has the potential for well-recognised biases. Informational biases occur from the distorted context when an expert witness knows which specific finding is present and the severity of the injury sustained as a result of the undiagnosed finding. Systemic litigation biases occur from the selection and undersampling of opinions and issues with compensation and affiliation between the expert and parties to litigation. Blinding the expert witness to outcomes holds potential for mitigating these biases and may act as a screening tool to evaluate civil claims. The more complex strategies of blinding the expert to both the legal case and the commissioning legal party, by providing a "library of imaging" for review to imitate a normal day's work, are unlikely to be practical for Australian legal practice. The persuasiveness of blinded expert evidence in mediation, concurrent evidence and court decisions in Australia is still uncertain.
Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prel... more Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prelabour rupture of the membranes, chorioamnionitis, postpartum endometritis and preterm labour and delivery. It is easy to diagnose and treat; intervention reduces the incidence of adverse sequelae. Symptomatic women and those who are at increased risk of infectious morbidity should be screened.
Archives of Gynecology and Obstetrics, Feb 26, 2015
To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (... more To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (FMRI) over the past decade in the diagnosis of anomalies of the corpus callosum in a tertiary referral centre. A single tertiary referral centre ultrasound database was searched for cases of suspected callosal anomalies between 2003 and 2012. All subsequent ultrasound scans, MRIs, neonatal imaging, postmortem investigations and birth records were reviewed. Callosal anomalies were classified into isolated or complex based on the presence or absence of accompanying congenital anomalies. Forty-three cases of callosal anomaly were detected; 60 % were investigated by FMRI revealing additional diagnoses in 23 %; half of which were anomalies of cortical development. Of those considered isolated who underwent FMRI, 21 % were diagnosed with additional anomalies, changing the classification to a complex callosal anomaly. In cases of callosal anomaly suspected on ultrasound, FMRI provides greater certainty and the potential to identify significant additional anomalies. The additional information may alter or clarify prognosis and help parents to better understand the pathology, allowing for informed decisions about the pregnancy to be made. However, some cases may still be diagnosed with additional anomalies after delivery and parents should be aware of such limitations of antenatal imaging.
Methods Hospital ultrasound and MRI databases were searched for cases of suspected callosal anoma... more Methods Hospital ultrasound and MRI databases were searched for cases of suspected callosal anomalies between 2003 and 2012. Subsequent ultrasound scans, fetal MRI, postnatal imaging, postmortem investigations and birth records were reviewed. Fetuses with major additional extracranial anomalies, abnormal karyotype and multiple pregnancies were excluded. Callosal anomalies were classified into isolated or complex based on the presence or absence of accompanying intracranial findings.
Reproductive sciences (Thousand Oaks, Calif.), Jan 16, 2016
Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating w... more Heavy menstrual bleeding (HMB) is a significant social and public health issue for menstruating women. Development of targeted treatments has been limited by poor understanding of local mechanisms underlying HMB. We aimed to determine how gene expression differs in menstrual phase endometrium from women with HMB. Menstrual phase endometrial biopsies were collected from women with (n = 7) and without (n = 10) HMB (regular menstrual cycles, no known pelvic pathology), as well as women with uterine fibroids (n = 7, n = 4 had HMB). Biopsies were analyzed using Illumina Sentrix Human HT12 arrays and data analyzed using "Remove Unwanted Variation-inverse". Ingenuity Pathway Analysis and the Database for Annotation, Visualization and Integrated Discovery v6.7 were used to identify gene pathways, functional gene clusters, and upstream regulators specific to the clinical groupings. Individual genes of interest were examined using quantitative polymerase chain reaction. In total, 82...
Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prel... more Bacterial vaginosis is associated with adverse sequelae, including late miscarriage, preterm prelabour rupture of the membranes, chorioamnionitis, postpartum endometritis and preterm labour and delivery. It is easy to diagnose and treat; intervention reduces the incidence of adverse sequelae. Symptomatic women and those who are at increased risk of infectious morbidity should be screened.
Archives of gynecology and obstetrics, Jan 26, 2015
To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (... more To assess the diagnostic accuracy of antenatal ultrasound and foetal magnetic resonance imaging (FMRI) over the past decade in the diagnosis of anomalies of the corpus callosum in a tertiary referral centre. A single tertiary referral centre ultrasound database was searched for cases of suspected callosal anomalies between 2003 and 2012. All subsequent ultrasound scans, MRIs, neonatal imaging, postmortem investigations and birth records were reviewed. Callosal anomalies were classified into isolated or complex based on the presence or absence of accompanying congenital anomalies. Forty-three cases of callosal anomaly were detected; 60 % were investigated by FMRI revealing additional diagnoses in 23 %; half of which were anomalies of cortical development. Of those considered isolated who underwent FMRI, 21 % were diagnosed with additional anomalies, changing the classification to a complex callosal anomaly. In cases of callosal anomaly suspected on ultrasound, FMRI provides greater c...
ABSTRACT The ‘standard of care’ for chromosome testing has recently changed. For the last 30 year... more ABSTRACT The ‘standard of care’ for chromosome testing has recently changed. For the last 30 years it has involved chromosome testing using microscope analysis. New technology using ‘DNA chips’, i.e. molecular karyotyping or microarray has now become available and is routinely offered to pregnant women undergoing invasive testing for an ultrasound detected fetal abnormality.
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