Papers by Syed usama haider
Cureus, 2018
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Cureus, 2018
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Cureus, Jan 15, 2018
Objectives Bibliometrics are used to assess or compare the academic productivity of individuals o... more Objectives Bibliometrics are used to assess or compare the academic productivity of individuals or groups. Most of these metrics, including the widely used -index, do not recognize the added contribution that is generally provided by authors listed first, second, second-to-last and last (enhanced positions) in a publication citation. We propose the -index as a novel modification to the -index that will better reflect an individual's academic output, incorporating authorship position. Methods One hundred and sixty-six academic neurosurgeons in eight New York City (NYC) metropolitan region training programs were identified through department websites. Using the Scopus citation database, bibliometric profiles were created for each surgeon. Once an individual's -index was calculated, the -core articles (those with or more citations) were specifically assessed to determine citation author position. Novel bibliometric indices were created to reflect the number of -core articles th...
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Cureus, Jan 24, 2018
Background and objective The high incidence of traumatic brain injuries during contact sports has... more Background and objective The high incidence of traumatic brain injuries during contact sports has necessitated the need for further research pertaining to their implications and possible mitigation. Despite increasing attention to sports-related concussions, there is still a striking lack of detail pertaining to the environmental factors that contribute to their occurrence. One environmental condition that has yet to be considered is altitude. Altitude cannot be readily adjusted, yet can still impact quality of play and concussion incidence. The current body of published evidence evaluating environmental effects on concussion is divided on the degree to which altitude mitigates concussion incidence. We aim to systematically compare the prevalence of concussions that occur at high and low altitude utilizing 1000 feet (304.8 meters) as a cut-off marker for high altitude. Our research also takes a novel approach utilizing average games missed as a proxy for concussion severity. We hope...
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World neurosurgery, Jan 27, 2018
Spinal surgery is taught and practiced within 2 different surgical disciplines, neurological surg... more Spinal surgery is taught and practiced within 2 different surgical disciplines, neurological surgery and orthopedic surgery. We have provided a unified analysis of academic productivity measured using the h-index attributable to spine-focused faculty at U.S. residency programs. A total of 278 Accreditation Council for Graduate Medical Education training programs were assessed to identify 923 full-time faculty members with a spinal surgery designation, as defined by spine fellowship training or case volume >75% in spine surgery. The faculty were assessed with respect to academic rank, duration of practice in years, and academic productivity (h-index). The comparison showed a significantly greater mean h-index for neurological spine surgeons. The mean h-index for both disciplines increased significantly as faculty rank increased. Within the academic ranks of assistant and associate professor, neurological spine surgeons had significantly greater mean h-indexes. Neurological spine s...
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Cancer research, 2018
Cancer differs significantly between men and women; even after adjusting for known epidemiologic ... more Cancer differs significantly between men and women; even after adjusting for known epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy. These differences occur in many but not all tumor types, and their origins remain largely unknown. Here, we compare somatic mutation profiles between tumors arising in men and in women. We discovered large differences in mutation density and sex biases in the frequency of mutation of specific genes; these differences may be associated with sex biases in DNA mismatch repair genes or microsatellite instability. Sex-biased genes include well-known drivers of cancer such as β-catenin and Sex influenced biomarkers of patient outcome, where different genes were associated with tumor aggression in each sex. These data call for increased study and consideration of the molecular role of sex in cancer etiology, progression, treatment, and personalized therapy. This study provides a comprehensive catalog of sex differenc...
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World neurosurgery, Jan 6, 2018
Spinal surgery is taught and practiced within two different surgical disciplines: neurological su... more Spinal surgery is taught and practiced within two different surgical disciplines: neurological surgery and orthopedic surgery. This article provides a unified analysis of spine-focused faculty at U.S. residency programs. 278 Accreditation Council for Graduate Medical Education (ACGME) training programs were assessed to identify 923 full-time faculty members with spinal surgery designation defined by spine fellowship training or surgeon case volume >75% spine surgeries. Faculty were assessed with respect to parent discipline, years of fellowship training, academic rank, gender, and academic productivity (h-index). The spine-teaching workforce contains 55% orthopedic surgeons and 45% neurosurgeons with wide gender asymmetry overall and at all faculty ranks. Of the female spine surgeons, those with neurosurgical training (64.44%) nearly doubled the number with orthopedic training (35.56%). Academic productivity increased with academic rank similarly for both genders and subspecialti...
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Cureus, 2018
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EBioMedicine, 2018
Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and val... more Hypoxia is associated with a poor prognosis in prostate cancer. This work aimed to derive and validate a hypoxia-related mRNA signature for localized prostate cancer. Hypoxia genes were identified in vitro via RNA-sequencing and combined with in vivo gene co-expression analysis to generate a signature. The signature was independently validated in eleven prostate cancer cohorts and a bladder cancer phase III randomized trial of radiotherapy alone or with carbogen and nicotinamide (CON). A 28-gene signature was derived. Patients with high signature scores had poorer biochemical recurrence free survivals in six of eight independent cohorts of prostatectomy-treated patients (Log rank test P < .05), with borderline significances achieved in the other two (P < .1). The signature also predicted biochemical recurrence in patients receiving post-prostatectomy radiotherapy (n = 130, P = .007) or definitive radiotherapy alone (n = 248, P = .035). Lastly, the signature predicted metastasi...
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Cell metabolism, Jan 12, 2018
Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, the... more Late-phase clinical trials investigating metformin as a cancer therapy are underway. However, there remains controversy as to the mode of action of metformin in tumors at clinical doses. We conducted a clinical study integrating measurement of markers of systemic metabolism, dynamic FDG-PET-CT, transcriptomics, and metabolomics at paired time points to profile the bioactivity of metformin in primary breast cancer. We show metformin reduces the levels of mitochondrial metabolites, activates multiple mitochondrial metabolic pathways, and increases 18-FDG flux in tumors. Two tumor groups are identified with distinct metabolic responses, an OXPHOS transcriptional response (OTR) group for which there is an increase in OXPHOS gene transcription and an FDG response group with increased 18-FDG uptake. Increase in proliferation, as measured by a validated proliferation signature, suggested that patients in the OTR group were resistant to metformin treatment. We conclude that mitochondrial re...
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Improving and expanding education is considered as a milestone for women empowerment in any socie... more Improving and expanding education is considered as a milestone for women empowerment in any society. Open Distance Learning (ODL) system of education is playing an important role especially in developing countries, to provide education to women. The aim of the paper was to assess the role of Open Distance Learning (ODL) system in economic empowerment of women in Pakistan which could reduce the poverty and ultimately can boost up the process of overall national development. AIOU’s role was tried to explore in a) increasing the chances of employment and b) improved control over family resources by enhanced economic contribution, of its female beneficiaries. For the purpose, data on questionnaire was collected from 3000 randomly selected postgraduate female students of Allama Iqbal Open University from 20 selected regions on the basis of their representative proportion in different faculties. The impact was measured in terms of what the female students of this university have felt and ...
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Papers by Syed usama haider