François Calot proposed to cure the articular tuberculosis by punctures of the tuberculosis absce... more François Calot proposed to cure the articular tuberculosis by punctures of the tuberculosis abscess and by immobilisation of the joint. He succeeded in many cases which had not to undergo surgery and his method was recognized as the best one till the arrival of the antibiotic (streptomycine) in 1948 which allowed to carry out surgery in the tuberculosis of bones and joints.
Osteoporosis and cardiovascular diseases are epidemiologically associated. Calcification phenomen... more Osteoporosis and cardiovascular diseases are epidemiologically associated. Calcification phenomena of atherosclerotic plaque involve cytokines and growth factors also involved in bone remodeling. Drugs given for either of these two conditions could act on these mechanisms. Can osteoporosis drugs have an influence on the occurrence of cardiovascular events? Conversely, can the treatment of hypertension alter the course of osteoporosis? It is possible that administration of high doses of calcium (1g/day) in patients who already have important dietary intake can increase the risk of myocardial infarction. Epidemiological studies show links between low serum vitamin D levels and cardiovascular disease but interventional studies show that vitamin D administration in moderately deficient subjects vitamin D does not prevent the occurrence of cardiovascular events. Cohort studies show a beneficial effect of beta-blockers and thiazides administered to hypertensive patients: they reduce by 20...
Osteoporosis and cardiovascular disease were long viewed as independent of each other. However, n... more Osteoporosis and cardiovascular disease were long viewed as independent of each other. However, numerous epidemiological studies, which are discussed in the first part of this review, have provided incontrovertible evidence of a link. Thus, the risk of coronary artery disease and stroke is higher in patients with a history of osteoporotic fracture or low bone mineral density than in non-osteoporotic patients. In the other direction, patients with cardiovascular disease are at higher risk for bone loss and osteoporotic fracture. The link between osteoporosis and cardiovascular disease is due in part to shared conventional risk factors such as estrogen deprivation in women, smoking, low physical activity, and diabetes. In addition, atheroma plaque calcification involves cytokines and growth factors that also play a role in bone turnover, including proinflammatory cytokines (IL-6 and TNFα), osteoprotegerin, sclerostin, matrix GLA protein, and FGF-23. Several recent studies have provided support for these pathophysiological hypotheses. Thus, elevation of osteoprotegerin, sclerostin, or FGF-23 levels may explain and predict the occurrence of both osteoporotic fractures and cardiovascular events. The association between osteoporosis and cardiovascular disease found in most epidemiological and pathophysiological studies suggests a need for evaluating potential benefits from routine bone absorptiometry and osteoporotic fracture detection in patients with cardiovascular disease and from exercise testing and arterial Doppler imaging in patients with osteoporosis.
ABSTRACT La supplémentation en calcium d’origine pharmacologique est largement utilisée pour la p... more ABSTRACT La supplémentation en calcium d’origine pharmacologique est largement utilisée pour la prévention de la carence en apports alimentaires de calcium ou comme traitement adjuvant de l’ostéoporose. Quelques études, analyses secondaires d’essais thérapeutiques, méta-analyses font état d’un risque augmenté d’accidents cardiovasculaires, essentiellement des infarctus du myocarde. Cet effet indésirable pourrait être causé par la constitution de calcifications vasculaires. Il n’existe pas pour l’instant d’essai clinique destiné à démontrer spécifiquement la réalité de ce risque. Dans le doute, il est recommandé d’ajuster les apports de calcium par la supplémentation aux besoins de l’individu en fonction de son âge, de son sexe et de sa situation physiologique tout en privilégiant les apports de calcium d’origine alimentaire.
François Calot proposed to cure the articular tuberculosis by punctures of the tuberculosis absce... more François Calot proposed to cure the articular tuberculosis by punctures of the tuberculosis abscess and by immobilisation of the joint. He succeeded in many cases which had not to undergo surgery and his method was recognized as the best one till the arrival of the antibiotic (streptomycine) in 1948 which allowed to carry out surgery in the tuberculosis of bones and joints.
Osteoporosis and cardiovascular diseases are epidemiologically associated. Calcification phenomen... more Osteoporosis and cardiovascular diseases are epidemiologically associated. Calcification phenomena of atherosclerotic plaque involve cytokines and growth factors also involved in bone remodeling. Drugs given for either of these two conditions could act on these mechanisms. Can osteoporosis drugs have an influence on the occurrence of cardiovascular events? Conversely, can the treatment of hypertension alter the course of osteoporosis? It is possible that administration of high doses of calcium (1g/day) in patients who already have important dietary intake can increase the risk of myocardial infarction. Epidemiological studies show links between low serum vitamin D levels and cardiovascular disease but interventional studies show that vitamin D administration in moderately deficient subjects vitamin D does not prevent the occurrence of cardiovascular events. Cohort studies show a beneficial effect of beta-blockers and thiazides administered to hypertensive patients: they reduce by 20...
Osteoporosis and cardiovascular disease were long viewed as independent of each other. However, n... more Osteoporosis and cardiovascular disease were long viewed as independent of each other. However, numerous epidemiological studies, which are discussed in the first part of this review, have provided incontrovertible evidence of a link. Thus, the risk of coronary artery disease and stroke is higher in patients with a history of osteoporotic fracture or low bone mineral density than in non-osteoporotic patients. In the other direction, patients with cardiovascular disease are at higher risk for bone loss and osteoporotic fracture. The link between osteoporosis and cardiovascular disease is due in part to shared conventional risk factors such as estrogen deprivation in women, smoking, low physical activity, and diabetes. In addition, atheroma plaque calcification involves cytokines and growth factors that also play a role in bone turnover, including proinflammatory cytokines (IL-6 and TNFα), osteoprotegerin, sclerostin, matrix GLA protein, and FGF-23. Several recent studies have provided support for these pathophysiological hypotheses. Thus, elevation of osteoprotegerin, sclerostin, or FGF-23 levels may explain and predict the occurrence of both osteoporotic fractures and cardiovascular events. The association between osteoporosis and cardiovascular disease found in most epidemiological and pathophysiological studies suggests a need for evaluating potential benefits from routine bone absorptiometry and osteoporotic fracture detection in patients with cardiovascular disease and from exercise testing and arterial Doppler imaging in patients with osteoporosis.
ABSTRACT La supplémentation en calcium d’origine pharmacologique est largement utilisée pour la p... more ABSTRACT La supplémentation en calcium d’origine pharmacologique est largement utilisée pour la prévention de la carence en apports alimentaires de calcium ou comme traitement adjuvant de l’ostéoporose. Quelques études, analyses secondaires d’essais thérapeutiques, méta-analyses font état d’un risque augmenté d’accidents cardiovasculaires, essentiellement des infarctus du myocarde. Cet effet indésirable pourrait être causé par la constitution de calcifications vasculaires. Il n’existe pas pour l’instant d’essai clinique destiné à démontrer spécifiquement la réalité de ce risque. Dans le doute, il est recommandé d’ajuster les apports de calcium par la supplémentation aux besoins de l’individu en fonction de son âge, de son sexe et de sa situation physiologique tout en privilégiant les apports de calcium d’origine alimentaire.
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