Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disorder of the cardiac mu... more Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disorder of the cardiac muscle characterised by ventricular arrhythmias, cardiac failure and sudden cardiac death. Desmosomes - the intercellular junctions of both epithelial and cardiovascular tissues that connect intermediate filaments of adjacent cells, generating a large and mechanically resilient network - are disordered in ARVC. Here, we exploit new insights into desmoplakin (DP), a critical component of desmosome structures. Indeed, both patient skin and keratinocytes expressing DP mutant construct showed large intercellular aggregates and a decrease in the amount of junctional proteins at areas of cell-cell contact. Moreover, experiments with DP knockout mice indicated that mislocalization of another junctional protein, connexin 43 was ameliorated by b-blocker (beta-blocker), or b-adrenergic receptor blocker - known to interfere with the binding to the receptor of epinephrine and other stress hormones to ...
Author(s): Huynh, Nga Kim | Advisor(s): Grubb, Norton; Little, Judith W | Abstract: Community col... more Author(s): Huynh, Nga Kim | Advisor(s): Grubb, Norton; Little, Judith W | Abstract: Community college has always been an attractive choice for many from the perspective that it offers access to higher education without the constraints typical of more elite four-year institutions. But while its egalitarian mission offers potentially unlimited second chances, the reality of persistent low attainment rates--despite investments in new initiatives and interventions--brings us back to the question of how community colleges both promote and constrain opportunities for students. To shed light on the viability of community college as an avenue to higher education, this study investigated the educational experiences of a group of students who transitioned directly from high school to community college in the fall of 2007. The design of the study employed multiple in-depth interviews with students over a twenty-month period. Forty youths from four high schools in two urban school districts in ...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disorder of the cardiac mu... more Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a hereditary disorder of the cardiac muscle characterised by ventricular arrhythmias, cardiac failure and sudden cardiac death. Desmosomes - the intercellular junctions of both epithelial and cardiovascular tissues that connect intermediate filaments of adjacent cells, generating a large and mechanically resilient network - are disordered in ARVC. Here, we exploit new insights into desmoplakin (DP), a critical component of desmosome structures. Indeed, both patient skin and keratinocytes expressing DP mutant construct showed large intercellular aggregates and a decrease in the amount of junctional proteins at areas of cell-cell contact. Moreover, experiments with DP knockout mice indicated that mislocalization of another junctional protein, connexin 43 was ameliorated by b-blocker (beta-blocker), or b-adrenergic receptor blocker - known to interfere with the binding to the receptor of epinephrine and other stress hormones to ...
Author(s): Huynh, Nga Kim | Advisor(s): Grubb, Norton; Little, Judith W | Abstract: Community col... more Author(s): Huynh, Nga Kim | Advisor(s): Grubb, Norton; Little, Judith W | Abstract: Community college has always been an attractive choice for many from the perspective that it offers access to higher education without the constraints typical of more elite four-year institutions. But while its egalitarian mission offers potentially unlimited second chances, the reality of persistent low attainment rates--despite investments in new initiatives and interventions--brings us back to the question of how community colleges both promote and constrain opportunities for students. To shed light on the viability of community college as an avenue to higher education, this study investigated the educational experiences of a group of students who transitioned directly from high school to community college in the fall of 2007. The design of the study employed multiple in-depth interviews with students over a twenty-month period. Forty youths from four high schools in two urban school districts in ...
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