Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry, 2009
Preparation of five silver(I) complexes of glutathione (Glut) [Ag(Glut)1, [Ag(Glut)2] − , [(Metu)... more Preparation of five silver(I) complexes of glutathione (Glut) [Ag(Glut)1, [Ag(Glut)2] − , [(Metu)2Ag(Glut)], [(Tmtu)1Ag(Glut)] and [(Tmtu)2Ag(Glut)] (where, Metu = N-methylthiourea and Tmtu = N,N,N ,N -tetramethylthiourea) has been attempted and the products were ...
Aims and Method The issue of elderly psychiatric patients remaining in hospitals after being decl... more Aims and Method The issue of elderly psychiatric patients remaining in hospitals after being declared medically fit is of concern to doctors, hospital managers and politicians alike. This article sets out the findings from a study involving elderly psychiatric patients at a district general hospital, undertaken to establish the actual lengths, reasons for and financial implications of delays in discharge. The study involved 50 in-patients, all of whom had been discharged over the 3-month study period. Results More than half of the patients in the sample were subject to some delay in discharge and for patients waiting for Elderly Mentally Infirm (EMI) placements this averaged 50 days. Collectively, nearly 25% of the time spent in hospital was due to delay. The cost to the hospital was estimated at more than £700 000 in 1 year. Clinical Implications Patients are being put at extra risk in terms of their health by being delayed in hospital. Issues of institutionalisation, nosocomial in...
This study estimates degree of intrinsic inflation persistence in Pakistan using aggregate price ... more This study estimates degree of intrinsic inflation persistence in Pakistan using aggregate price index, group level price indices, and individual commodity prices. Monthly data from 1959 to 2011 is used for the analysis. [SBP WP no. 52].
Execution of the mitochondrial death signaling is paramount to an effective response of cancer ce... more Execution of the mitochondrial death signaling is paramount to an effective response of cancer cells to chemotherapeutic intervention. Therefore, factors that inhibit the engagement of the mitochondrial amplification pathway, such as the expression of the anti-apoptotic proteins of the Bcl2 family or inactivation of inducers of mitochondrial permeability, play a critical role in the acquisition of the resistant phenotype. Protein kinase CK2 (CK2) is a ubiquitous serine/threonine kinase that is highly conserved in eukaryotic cells. This multifunctional protein kinase has been shown to impact cell growth and proliferation, as numerous growth-related proteins are substrates of CK2. More importantly, experimental evidence linking increased expression and activity of the kinase to human cancers, underscores the relevance of CK2 biology to cellular transformation and carcinogenesis. Of note, among the many cellular substrates of CK2 are proteins involved in the efficient execution of the mitochondria-dependent cell death signaling, such as Bid, caspase-2, ARC and others. Supporting this, recent reports have demonstrated that genetic manipulation of CK2 expression as well as pharmacological inhibition of its enzymatic activity sensitizes cancer cells to apoptotic stimuli. Due to the critical regulatory role that this kinase plays in cell fate determination in cancer cells, there is a tremendous increase in activity geared at the development of CK2-specific therapies. Here we provide a brief review of CK2-mediated inhibition of mitochondrial death signaling in cancer cells and its implications for the design of novel target specific therapeutic strategies.
Page 1. STATE BANK OF PAKISTAN May, 2010 No. 33 Muhammad Farooq Arby Muhammad Jahanzeb Malik Muha... more Page 1. STATE BANK OF PAKISTAN May, 2010 No. 33 Muhammad Farooq Arby Muhammad Jahanzeb Malik Muhammad Nadim Hanif The Size of Informal Economy in Pakistan SBP Working Paper Series Page 2. SBP Working Paper Series Editor: Riaz Riazuddin ...
... A notable tendency was also seen towards family planning in the respondents, who were watchin... more ... A notable tendency was also seen towards family planning in the respondents, who were watching TV programs. ... On many occasions, it was brought into the notice of the Holy Prophet Muhammad (SAW) that some Sahaba Ikraam used to undergo this practice but the Holy ...
The fracturing of rocks in mines and quarries may be regarded as the first stage of comminution. ... more The fracturing of rocks in mines and quarries may be regarded as the first stage of comminution. The use of commercially available expansive materials in the dimension stone quarries is on the increase due to their effectiveness in controlled fracturing. However, ...
Trimethyltin(IV) complex containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) ha... more Trimethyltin(IV) complex containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) have been synthesized and characterized in solution state by multinuclear NMR (1H, 13C and 119Sn) using the noncoordinating solvent and also in solid sate by FTIR, mass ...
Synthesis and Reactivity in Inorganic Metal-Organic and Nano-Metal Chemistry, 2009
Preparation of five silver(I) complexes of glutathione (Glut) [Ag(Glut)1, [Ag(Glut)2] − , [(Metu)... more Preparation of five silver(I) complexes of glutathione (Glut) [Ag(Glut)1, [Ag(Glut)2] − , [(Metu)2Ag(Glut)], [(Tmtu)1Ag(Glut)] and [(Tmtu)2Ag(Glut)] (where, Metu = N-methylthiourea and Tmtu = N,N,N ,N -tetramethylthiourea) has been attempted and the products were ...
Aims and Method The issue of elderly psychiatric patients remaining in hospitals after being decl... more Aims and Method The issue of elderly psychiatric patients remaining in hospitals after being declared medically fit is of concern to doctors, hospital managers and politicians alike. This article sets out the findings from a study involving elderly psychiatric patients at a district general hospital, undertaken to establish the actual lengths, reasons for and financial implications of delays in discharge. The study involved 50 in-patients, all of whom had been discharged over the 3-month study period. Results More than half of the patients in the sample were subject to some delay in discharge and for patients waiting for Elderly Mentally Infirm (EMI) placements this averaged 50 days. Collectively, nearly 25% of the time spent in hospital was due to delay. The cost to the hospital was estimated at more than £700 000 in 1 year. Clinical Implications Patients are being put at extra risk in terms of their health by being delayed in hospital. Issues of institutionalisation, nosocomial in...
This study estimates degree of intrinsic inflation persistence in Pakistan using aggregate price ... more This study estimates degree of intrinsic inflation persistence in Pakistan using aggregate price index, group level price indices, and individual commodity prices. Monthly data from 1959 to 2011 is used for the analysis. [SBP WP no. 52].
Execution of the mitochondrial death signaling is paramount to an effective response of cancer ce... more Execution of the mitochondrial death signaling is paramount to an effective response of cancer cells to chemotherapeutic intervention. Therefore, factors that inhibit the engagement of the mitochondrial amplification pathway, such as the expression of the anti-apoptotic proteins of the Bcl2 family or inactivation of inducers of mitochondrial permeability, play a critical role in the acquisition of the resistant phenotype. Protein kinase CK2 (CK2) is a ubiquitous serine/threonine kinase that is highly conserved in eukaryotic cells. This multifunctional protein kinase has been shown to impact cell growth and proliferation, as numerous growth-related proteins are substrates of CK2. More importantly, experimental evidence linking increased expression and activity of the kinase to human cancers, underscores the relevance of CK2 biology to cellular transformation and carcinogenesis. Of note, among the many cellular substrates of CK2 are proteins involved in the efficient execution of the mitochondria-dependent cell death signaling, such as Bid, caspase-2, ARC and others. Supporting this, recent reports have demonstrated that genetic manipulation of CK2 expression as well as pharmacological inhibition of its enzymatic activity sensitizes cancer cells to apoptotic stimuli. Due to the critical regulatory role that this kinase plays in cell fate determination in cancer cells, there is a tremendous increase in activity geared at the development of CK2-specific therapies. Here we provide a brief review of CK2-mediated inhibition of mitochondrial death signaling in cancer cells and its implications for the design of novel target specific therapeutic strategies.
Page 1. STATE BANK OF PAKISTAN May, 2010 No. 33 Muhammad Farooq Arby Muhammad Jahanzeb Malik Muha... more Page 1. STATE BANK OF PAKISTAN May, 2010 No. 33 Muhammad Farooq Arby Muhammad Jahanzeb Malik Muhammad Nadim Hanif The Size of Informal Economy in Pakistan SBP Working Paper Series Page 2. SBP Working Paper Series Editor: Riaz Riazuddin ...
... A notable tendency was also seen towards family planning in the respondents, who were watchin... more ... A notable tendency was also seen towards family planning in the respondents, who were watching TV programs. ... On many occasions, it was brought into the notice of the Holy Prophet Muhammad (SAW) that some Sahaba Ikraam used to undergo this practice but the Holy ...
The fracturing of rocks in mines and quarries may be regarded as the first stage of comminution. ... more The fracturing of rocks in mines and quarries may be regarded as the first stage of comminution. The use of commercially available expansive materials in the dimension stone quarries is on the increase due to their effectiveness in controlled fracturing. However, ...
Trimethyltin(IV) complex containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) ha... more Trimethyltin(IV) complex containing the carboxylate ligand 2,3-methylenedioxybenzoic acid (HL) have been synthesized and characterized in solution state by multinuclear NMR (1H, 13C and 119Sn) using the noncoordinating solvent and also in solid sate by FTIR, mass ...
Uploads
Papers by Muhamad Hanif