Papers by Michelle Liberato
The Cambridge Structural Database, 2022
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International Journal of Human Sciences Research, Jan 26, 2022
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International Journal of Human Sciences Research, 2022
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Advanced Functional Materials, 2021
2D piezoelectric materials such as transition metal dichalcogenides are attracting significant at... more 2D piezoelectric materials such as transition metal dichalcogenides are attracting significant attention because they offer various benefits over bulk piezoelectrics. In this work, the fabrication of layered biomolecular crystals of diphenylalanine (FF) obtained via a co‐assembly of l,l‐ and d,d‐ enantiomers of FF monomers is reported. Their crystal structure, thermal and chemical stabilities, and piezoelectric properties are investigated. Single crystal X‐ray diffraction results show that FF enantiomers are arranged in the form of bilayers consisting of monomers with alternating chirality packed into a tape‐like monoclinic structure belonging to a polar space group P21. Each bilayer (≈1.5 nm thick) demonstrates strong out‐of‐plane piezoelectricity (d33 ≈ 20 pm V−1) that is almost an order of magnitude higher than in the archetypical piezoelectric material quartz. The grown crystals demonstrate better thermal and chemical stabilities than self‐assembled hexagonal FF nanotubes studied in the past. Piezoelectric bilayers, being held via weak aromatic interaction in the bulk crystals, can be exfoliated by mechanical or chemical methods, thus resulting in a 2D piezoelectric material, which can find various applications in biocompatible and ecologically friendly electromechanical microdevices, such as sensors, actuators, and energy harvesting elements used in implantable and wearable electronics.
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Colloids and surfaces. B, Biointerfaces, Jan 11, 2017
This paper describes the development of a facile and environmentally friendly strategy for suppor... more This paper describes the development of a facile and environmentally friendly strategy for supporting crotamine on gold nanoparticles (GNPs). Our approach was based on the covalent binding interaction between the cell penetrating peptide crotamine, which is a snake venom polypeptide with preference to penetrate dividing cells, and a polyethylene glycol (PEG) ligand, which is a nontoxic, water-soluble and easily obtainable commercial polymer. Crotamine was derivatized with ortho-pyridyldisulfide-polyethyleneglycol-N-hydroxysuccinimide (OPSS-PEG-SVA) cross-linker to produce OPSS-PEG-crotamine as the surface modifier of GNP. OPSS-PEG-SVA can serve not only as a surface modifier, but also as a stabilizing agent for GNPs. The successful PEGylation of the nanoparticles was demonstrated using different physicochemical techniques, while the grafting densities of the PEG ligands and crotamine on the surface of the nanoparticles were estimated using a combination of electron microscopy and ma...
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Physical chemistry chemical physics : PCCP, Jan 20, 2016
A novel enzymatic platform for the sensing of H2O2 and glucose that uses l,l-diphenylalanine micr... more A novel enzymatic platform for the sensing of H2O2 and glucose that uses l,l-diphenylalanine micro/nanostructures (FF-MNSs) as an enzyme support is shown. This platform is obtained by the self-assembly of poly(allylamine hydrochloride) (PAH), FF-MNSs, and microperoxidase-11 (MP11) anchored onto the peptide matrix, in two different crystal structures of FF-MNSs: hexagonal (P61) and orthorhombic (P22121). The electroactive area of the electrodes increases in the presence of FF-MNSs. We also demonstrate via theoretical calculations that the valence band energy of the orthorhombic structure allows it to be doped, similarly to p-type semiconductors, where PAH acts as a doping agent for the orthorhombic peptide structure, decreasing the band-gap by around 1 eV, which results in a smaller charge transfer resistance. These results are consistent with electrochemical impedance spectroscopy measurements, which further elucidate the role of the band structure of the orthorhombic FF-MNSs in the...
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Langmuir, 2015
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The Journal of Physical Chemistry C, 2014
ABSTRACT We report here the fabrication of a biomimetic sensor for direct oxygen reduction; the s... more ABSTRACT We report here the fabrication of a biomimetic sensor for direct oxygen reduction; the sensor consists of multicopper oxidases derived from cyclic-tetrameric copper(II) species containing the ligand (4-imidazolyl)ethylene-2-amino-1-ethylpyridine (apyhist) that are self-assembled with l-diphenylalanine micro/nanostructures (FF-MNTs). The [Cu4(apyhist)4]4+/FF-MNT complex was immobilized onto the surface of a glassy carbon (GC) electrode by poly ion complex formation with a Nafion film. This hybrid membrane allows regular proton transport to a Cu-based molecular oxygen reduction reaction catalyst, and the imidazole group in the imine ligand (apyhist) acts as a local buffer in the vicinity of the O2 reducing center, thus aiding the catalyst in retaining its selectivity for 4e–/4H+ oxygen reduction reaction. This nanocomposite provided improved sensing characteristics in the electrode interface with respect to the electroactive surface area, the diffusion coefficient, and the electron transfer kinetics. In addition, the hybrid film [Cu4(apyhist)4]4+/FF-MNT-coated GC electrode was successfully used as an enzymeless electrochemical sensor for the detection of dissolved oxygen in aqueous media at two concentration intervals, viz., 0.2–3.0 mg L–1 and greater than 3.0 mg L–1, with sensitivities of 25.0 and 80.2 μA L mg–1 cm–2, respectively, and a detection limit of 0.1 mg L–1. Evaluated in terms of relative standard deviation, the repeatability of the proposed sensor was less than 9.0% for ten measurements of a solution of 6.5 mg L–1 oxygen. Experimental efforts were conducted to use this proposed platform for O2 determination with real samples. Results from theoretical investigations using density functional theory support the hypothesis that the [Cu4(apyhist)4]4+ complex can act as the sole source of protons and electrons in the O2 reduction reaction.
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New Perspectives in Biosensors Technology and Applications, 2011
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The Journal of Physical Chemistry B, 2013
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Journal of Materials Chemistry B, 2016
The conjugation between micro/nanotubes of l,l-diphenylalanine and polycaprolactone has led to du... more The conjugation between micro/nanotubes of l,l-diphenylalanine and polycaprolactone has led to ductile composite fibers suitable for designing polymer membranes potentially usable as degradable skin patches in drug delivery.
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The Journal of Physical Chemistry C, 2017
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Soft Matter
The formation of hydrogels through photosensitized oxidation and crosslinking of histidine-derive... more The formation of hydrogels through photosensitized oxidation and crosslinking of histidine-derived polymers is demonstrated for the first time. The photooxidation of pendant His mediated by singlet oxygen was used to...
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Advanced Functional Materials
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ACS Applied Electronic Materials
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Papers by Michelle Liberato