Papers by Mansour Dabirzadeh
Archives of Iranian Medicine, Jun 30, 2023
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Annals of parasitology, 2022
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Medical Laboratory Journal, 2017
Background and objective: Surgery is the gold standard treatment for hydatidosis. Scolicidal agen... more Background and objective: Surgery is the gold standard treatment for hydatidosis. Scolicidal agents could be used during surgery to kill protoscoleces and prevent cyst recurrence after rupturing of main lesion. Non-chemical agents with sufficient protoscolex-killing activity are known to be fully effective in this regard with fewer side effects. Fig tree is an Iranian native plant, which has been used for medicinal purposes in traditional medicine. Methods: After obtaining infected hydatid cyst of the liver from a slaughterhouse in Babol (Iran), the percentage of live protoscoleces was calculated by critical staining with 0.1 % eosin. Then, the protoscolex-killing activity of methanolic extract of fig leaves was evaluated at concentrations of 2.5, 5, 10, 15 and 20 mg/ml in 2, 4, 8, 12, and 16 minutes exposure times. Statistical analysis was performed using SPSS software (version 22). Results: Concentration of 20 mg/ml of the extract showed 100% protoscolex-killing activity within th...
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KAUMS Journal, 2016
Background: Pentavalent antimonate compounds are the routine drugs for leishmaniasis. Apart from ... more Background: Pentavalent antimonate compounds are the routine drugs for leishmaniasis. Apart from side effects, relapse and drug resistance are among the main problems of these compounds. Hawthorn has antioxidant and antibacterial effects. The aim of present study was to determine the anti-leishmanial effect of hawthorn fruit extract in vitro. Materials and Methods: In this experimental study different doses of hawthorn fruit extract was added to Leishmania major promastigotes. Cytotoxicity was investigated by both direct counting and MTT assay after 24, 48 and 72 hours. In addition, hawthorn extract was added to amastigote-infected macrophages and then the mean of amastigote per macrophage was counted after 24 and 48 hours. Data were analyzed using one-way ANOVA. Results: The cytotoxicity of the highest and lowest concentration of the extract (60 µg/ml and 0.5 µg/ml) after 24, 48 and 72 hours was 31.86, 27.93; 20.11, 20.94; and 35.19, 55.14, respectively. After 24 hours the IC50 was...
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Iranian Journal of Public Health, 2022
The article's abstract is not available.
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Background and Objective: Leishmania major is a flagellate protozoan parasite causing cutaneous l... more Background and Objective: Leishmania major is a flagellate protozoan parasite causing cutaneous leishmaniasis. Although pentavalent antimony compounds are the first-line drugs for leishmaniasis, their application is often accompanied by numerous limitations and side effects. Therefore, it is necessary to seek drugs of herbal origin that have fast-acting benefits and few side effects without resistance. This study aimed to evaluate the in vitro effects of methanolic extract of Arctiul lappa root on promastigotes and amastigotes of L. major. Methods: This experimental study evaluated the effects of 10, 100, 500, and 1000 µg/ml of A. lappa root methanol extract on L. major promastigotes using direct cell counting and MTT assay. The mean number of amastigotes in infected macrophages was calculated after 24 and 48 hours. Results: The half maximal inhibitory concentration (IC50) of A. lappa root methanolic extract was 131.25 µg/ml after 24 hours. The mean number of amastigotes in macropha...
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Medical Laboratory Journal, 2018
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Background Cryptosporidiosis has a worldwide distribution, and is the commonest cause of diarrhea... more Background Cryptosporidiosis has a worldwide distribution, and is the commonest cause of diarrhea in children and immune compromised individuals. Since there is no data available on the prevalence of Cryptosporidium species (sp.) in Zabol city, thus this study was carried out to assess the disease prevalence and related factors influencing the disease.
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Official Website Iranian Journal Of Dermatology. Comprehensive Research Information Management Sy... more Official Website Iranian Journal Of Dermatology. Comprehensive Research Information Management System. http://iranjd.jo.research.ac.ir. ...
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Journal of Medicinal Plants, 2016
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Medical Laboratory Journal, 2015
ِلبقه عسدآ ُذقً یئبؿبپ ، ُداصشیثد ،م یدٍاد ،ط یوؿبّ م " وػلاپَؼکَت یطَلَیهذیپاٍشػ صَ غجع شْؿ... more ِلبقه عسدآ ُذقً یئبؿبپ ، ُداصشیثد ،م یدٍاد ،ط یوؿبّ م " وػلاپَؼکَت یطَلَیهذیپاٍشػ صَ غجع شْؿ سادسبث ىبًص سد " مَلػ ِلده شیت ٍ دادشخ ،یّبگـیبهصآ 94 ُسبوؿ( نًْ ُسٍد ، 2 :) 119 126 ُذقً یئبؿبپ عبجع ذؿسا عبٌؿسبک یػبٌؿ لگًا ذسبق ٍ یػبٌؿ لگًا ٍُشگ ، ،لثاص یکؿضپ مَلػ ُبگـًاد ،یکؿضپ ُذکـًاد ،یػبٌؿ ىاشیا ُداصشیثد سَصٌه ذسبق ٍ یػبٌؿ لگًا ٍُشگ ،یکؿضپ یػبٌؿ لگًا سبیدبتػا ،لثاص یکؿضپ مَلػ ُبگـًاد ،یکؿضپ ُذکـًاد ،یػبٌؿ ىاشیا
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Introduction Trichomoniasis is one of the most common sexually transmitted diseases in the world,... more Introduction Trichomoniasis is one of the most common sexually transmitted diseases in the world, which is caused by Trichomonas vaginalis. It is also the most commonly transmitted infectious disease after viral infections (1). The parasite lives in a woman’s vagina, especially the cervix, and in the urethra, and in men’s prostate gland (2). In women, infection with T. vaginalis can cause vaginal, cervical, and urethral inflammations (3,4). Clinically, not only the establishment of the parasite in the vaginal wall does not cause clinical symptoms, but also many physiological and pathological factors such as estrogen, glycogen, and pH of the vagina are effective in the growth and pathogenicity of trichomoniasis (5,6). The parasite grows better in a humid environment, in a pH range of 4.9 to 7.5 and temperature of 35°C to 37°C, and if these conditions are less or greater than the desired level, the organism is destroyed (7). T. vaginalis can be transmitted to the infant during the lab...
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Journal of Gorgan University of Medical Sciences, 2003
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Background Cryptosporidiosis has a worldwide distribution, and is the commonest cause of diarrhea... more Background Cryptosporidiosis has a worldwide distribution, and is the commonest cause of diarrhea in children and immune compromised individuals. Since there is no data available on the prevalence of Cryptosporidium species (sp.) in Zabol city, thus this study was carried out to assess the disease prevalence and related factors influencing the disease. Materials and Methods In this cross-sectional study, 200 fecal specimens were collected from children referred to the Central or hospital labs in Zabol city, South East of Iran, during April 2014 to August 2016. Fecal examination was performed by staining with Ziel-Neelsen acid-fast to find oocysts of the parasite. The children were grouped according to the age, gender, kind of water supplies, and diarrheic and non-diarrheic condition. Data were evaluated using SPSS version 13.0 software. Results Among the children referred to the Central laboratory, 200 fecal samples from different age groups were collected. The prevalence of Cryptos...
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Background and purpose: Hydatid cyst is a zoonotic world-wide infection, caused by larval stage o... more Background and purpose: Hydatid cyst is a zoonotic world-wide infection, caused by larval stage of Echinococcus granulosus. Its mean infection rate in Iran is 1.2 surgical case per 100,000. Hydatidosis is of great economic and medical importance. So, this study was designed to determine the seroprevalence of human hydatidosis using ELISA. Materials and methods: In this cross-sectional study, 536 blood samples were collected from Shahrebabak residents in 2014. Random cluster sampling was applied to select the participants. Demographic information including age, sex, job, history of contact with dog, and place of residence (city or village) were collected using a questionnaire. The samples were transferred to laboratory and investigated by ELISA. Data was analyzed in SPSS applying and Chi-square test. Results: Only one male (0.18%) was found to be positive (23 years of age) who was living in city, self-employed and had no history of contact with dog. Conclusion: According to this stud...
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Papers by Mansour Dabirzadeh