Papers by MUDr. Iveta Mečiarová
Ortopedia, traumatologia, rehabilitacja, May 10, 2017
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Acta Parasitologica
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International Journal of Molecular Sciences
Carbonic anhydrase IX (CA IX) is recognized as an excellent marker of hypoxia and an adverse prog... more Carbonic anhydrase IX (CA IX) is recognized as an excellent marker of hypoxia and an adverse prognostic factor in solid tumors, including breast cancer (BC). Clinical studies confirm that soluble CA IX (sCA IX), shed into body fluids, predicts the response to some therapeutics. However, CA IX is not included in clinical practice guidelines, possibly due to a lack of validated diagnostic tools. Here, we present two novel diagnostic tools—a monoclonal antibody for CA IX detection by immunohistochemistry and an ELISA kit for the detection of sCA IX in the plasma—validated on a cohort of 100 patients with early BC. We confirm that tissue CA IX positivity (24%) correlates with tumor grading, necrosis, negative hormone receptor status, and the TNBC molecular subtype. We show that antibody IV/18 can specifically detect all subcellular forms of CA IX. Our ELISA test provides 70% sensitivity and 90% specificity. Although we showed that this test could detect exosomes in addition to shed CA I...
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Journal of Neuromuscular Diseases, 2015
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The American Journal of Cosmetic Surgery, 2018
Pseudoangiomatous stromal hyperplasia (PASH) is a benign mesenchymal proliferative breast conditi... more Pseudoangiomatous stromal hyperplasia (PASH) is a benign mesenchymal proliferative breast condition. Although its prevalence is difficult to accurately estimate, tumor-forming PASH is a rather uncommon breast lesion. The exact etiology and pathogenesis of PASH is not clearly understood. It typically affects women in their reproductive years. While PASH has been described in female and male adults, it appears to be rare in the pediatric population. Herein, we review a case of an unusually large tumorous form of PASH, which caused massive breast asymmetry in a young woman. In the second case report, we describe a 17-year-old boy with tumorous PASH leading to asymmetric gynecomastia. In both cases, we present the clinical features, imaging results, histopathologic features, and surgical treatment of the disease.
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Molecular and Clinical Oncology, 2018
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Ortopedia Traumatologia Rehabilitacja, 2017
Bizarre parosteal osteochondromatous proliferation (BPOP) is an unusual lesion mostly affecting t... more Bizarre parosteal osteochondromatous proliferation (BPOP) is an unusual lesion mostly affecting the bones of the hand. The mass grows from the bone surface and consists of cartilaginous, osseous and fibrous tissue. The lesion is commonly under/misdiagnosed and confused with other lesions, mostly the osteochondromas. We present a patient with BPOP that initially confused the practitioner and radiologist in their diagnosis. We discuss the clinical, radiologic and histologic characteristics of BPOP of the hand since its first report in 1983 and present its main differential diagnosis. We reviewed 184 cases. Female were affected in 52% and male in 48%. Pro ximal phalanges were most commonly affected, followed by middle phalanges and metacarpals. Pain was reported in 47,9 % of all reported papers. The most common surgical treatment was by excision, and the rate of recurrence was 47.3%.
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Oncology Letters, 2017
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Neoplasma, 2016
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Ceska Urologie, 2014
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Ceská gynekologie / Ceská lékarská spolecnost J. Ev. Purkyne, 2014
To perform a review of Tuberous sclerosis complex and its complications during the pregnancy from... more To perform a review of Tuberous sclerosis complex and its complications during the pregnancy from up to date scientific literature. Complex systematic review of the literature. 2nd Department of Obstetrics and Gynaecology, University Hospital Bratislava, Comenius University, Bratislava, Slovak Republic. Complex analysis of the syndrome, systematic search of MEDLINE and Slovak Medical Library. The reason to create a complex review of this syndrome was our clinical experience with one of the most acute lifethreatening condition of this syndrome - acute retroperitoneal haemorrhage in the pregnancy. Tuberous sclerosis can cause a rare, but potentially lifethreatening complications, especially during the pregnancy. These should be carefully dispesarized and in complicated cases acute radical management should be considered.
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Klinicka onkologie, 2014
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Molecular and Clinical Oncology, 2018
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Journal of the Korean Radiological Society, 2008
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1 Bioptická laboratoř s.r.o., Šiklův ústav patologie, LF UK, Plzeň 2 Cytopathos s.r.o., Bratislav... more 1 Bioptická laboratoř s.r.o., Šiklův ústav patologie, LF UK, Plzeň 2 Cytopathos s.r.o., Bratislava 3 Alfa Medical Patológia, FN Ružinov, Bratislava 4 Ortopedická klinika, Univerzitná nemocnica Akademika Dérera, Bratislava 5 Gendiagnostika s.r.o., Košice 6 Ústav patologie a molekulární medicíny, 2. LF UK, FN Motol, Praha 7 Ortopedická klinika, Nemocnice na Bulovce, Praha 8 Ústav patologie, FN Prešov
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Ceskoslovenská patologie, 2015
The authors present five cases of periosteal osteosarcoma located in the femur (4) and tibia (1) ... more The authors present five cases of periosteal osteosarcoma located in the femur (4) and tibia (1) in children and young adults (1 female and 4 males) with an age range of 9 - 23 years (mean age 15 years). Radiographs in all cases showed a broad-based soft tissue mass attached to the cortex with periosteal reaction and in two of them cortical disruption with extensive medullary involvement. Follow-ups were available in four cases (range 11 - 73 months) and revealed pelvic metastasis after 15 months with ultimately rapid dissemination and death in a 9-year-old girl and metastasis to the humerus after 13 months in a 15-year-old boy. The former tumor widely extended into the medullary cavity and an amputation was carried out, the latter had a pure juxtacortical position and an en block resection was performed; both of them were treated with chemotherapy. All the lesions displayed distinctive structural patterns combining a large island of tumorous cartilage and hypocellular, bland-lookin...
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Ceskoslovenská patologie, 2015
The authors present a unique case of small cell variant of clear cell sarcoma of soft parts in a ... more The authors present a unique case of small cell variant of clear cell sarcoma of soft parts in a 42-year old woman. The tumor originally arose in the right flank of the soft tissues and ultimately developed both a local recurrence and multiple distant skin metastases two years and ten months thereafter. Nonspecific morphology of small blue round cell tumor was preserved at all microscopically verified sites and initially led to the spectrum of erroneous diagnoses such as an extraskeletal myxoid chondrosarcoma, Ewing sarcoma as well as malignant melanoma. The distinctive features of clear cell sarcoma such as fascicular nested growth pattern, spindling, clear cell change and/or eosinophilic cytoplasm were not disclosed even by extensive sampling. Immunohistochemically, the tumor expressed only S100protein and HMB45; all other markers (CD99, FLI1, cytokeratins, EMA) were completely negative. The molecular analysis carried out in one of the cutaneous metastases revealed translocation t...
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Ceskoslovenska patologie, 2016
Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operat... more Presented is a case of 59-year-old woman with longstanding neck pain who has been promptly operated for spinal cord compression. Imaging studies disclosed ill-defined cervical paravertebral soft tissue mass at the level of vertebra C5/6 abutting left-sided intervertebral joint and destroying neighboring both vertebral arch and processus spinosus. Submitted specimen was interpreted as a possible metastatic skeletal process by clinicians and referring pathologist favored diagnosis of giant cell tumor/osteoclastoma of the bone. Microscopic features were consistent with giant cell lesion where uniform mononuclear mosaic stromal component dominated the unevenly distributed loose clusters of osteoclast-like giant cells frequently imparting appearance of peculiar pseudoalveolar spaces. Additionally, alternating geographic xanthomatous and densely hyalinized/ osteoid-like zones with speckled, coarsely granular haemosiderin pigment completed the variegated structural composition. The tumor i...
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Papers by MUDr. Iveta Mečiarová