Papers by Bruno Locatelli
Paediatric anaesthesia, Mar 1, 2018
The prevalence of persistent postsurgical pain in children is over 20% after major surgeries; how... more The prevalence of persistent postsurgical pain in children is over 20% after major surgeries; however, data are scarce on the prevalence, character, and risk factors among children undergoing common ambulatory surgeries. The primary aim of this study was to evaluate the prevalence of persistent pain following pediatric ambulatory surgery at 1, 3, and 6 months. Secondary aims were to identify risk factors and characterize the pain and consequences of persistent postsurgical pain. ASA I-II, ages 1 month to 16 years old, undergoing elective hypospadias repair, herniorraphy, orchiopexy, and orthopedic surgery were enrolled in a prospective, longitudinal, observational study at 3 pediatric centers in Italy. All patients received general plus regional anesthesia. Postoperative pain was evaluated using age appropriate pain scales at 1 and 3 hours. At 1, 3, and 6 months, pain scores were obtained and Parent's Postoperative Pain Measures (<8 yo) and Child Activity Limitations Intervie...
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Lancet (London, England), Jan 23, 2015
Preclinical data suggest that general anaesthetics affect brain development. There is mixed evide... more Preclinical data suggest that general anaesthetics affect brain development. There is mixed evidence from cohort studies that young children exposed to anaesthesia can have an increased risk of poor neurodevelopmental outcome. We aimed to establish whether general anaesthesia in infancy has any effect on neurodevelopmental outcome. Here we report the secondary outcome of neurodevelopmental outcome at 2 years of age in the General Anaesthesia compared to Spinal anaesthesia (GAS) trial. In this international assessor-masked randomised controlled equivalence trial, we recruited infants younger than 60 weeks postmenstrual age, born at greater than 26 weeks' gestation, and who had inguinal herniorrhaphy, from 28 hospitals in Australia, Italy, the USA, the UK, Canada, the Netherlands, and New Zealand. Infants were randomly assigned (1:1) to receive either awake-regional anaesthesia or sevoflurane-based general anaesthesia. Web-based randomisation was done in blocks of two or four and ...
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Paediatric anaesthesia, 2013
This randomized control trial was designed to evaluate the incidence of emergence delirium (ED) i... more This randomized control trial was designed to evaluate the incidence of emergence delirium (ED) in preschool children receiving sevoflurane or desflurane anesthesia combined with an effective caudal block. While ED has been described in children receiving sevoflurane or desflurane anesthesia, a direct comparison between the two agents using a validated ED assessment tool has not been reported previously. Two hundred and sixty preschool children scheduled for elective sub-umbilical surgery were randomized to receive sevoflurane or desflurane anesthesia combined with a caudal block. ED was defined as a Paediatric Anesthesia Emergence Delirium scale (PAED) ≥ 10 points. A delirium-specific score (ED I) was calculated from the first three items of the PAED score (eye contact, purposeful actions, awareness of the surroundings) and a nonspecific score (ED II) from the last two items on the PAED score (restlessness and inconsolability) to test the hypothesis that some items of the PAED scal...
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American Journal of Nephrology, 2015
Background/Aims: In renal transplantation, peri-operative low-dose rabbit-antithymocyte-globulin ... more Background/Aims: In renal transplantation, peri-operative low-dose rabbit-antithymocyte-globulin (RATG) plus basiliximab induction prevented acute allograft rejection more effectively than post-operative RATG plus basiliximab induction. We investigated the specific antirejection contribution of basiliximab in this context. Methods: This single-center, observational, matched-cohort study evaluated allograft rejections (primary outcome), steroid exposure and side effects, GFR (iohexol plasma clearance) and treatment costs in 16 deceased-donor renal transplant recipients induced with RATG (0.5 mg/kg/day) and 32 age-, gender- and treatment-matched reference-patients given RATG plus basiliximab (20 mg on days 0 and 4). Results: Induction was well tolerated. At 18 months, 8 patients (50%) vs. 3 reference-patients (9.4%) rejected the graft [HR (95% CI): 6.53 (1.73-24.70), p = 0.006]. Difference was significant (p < 0.01) even after adjusting for recipient/donor age and gender, cold isch...
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Pediatric Anesthesia, 2007
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British Journal of Anaesthesia, 2008
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British Journal of Anaesthesia, 2005
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Pediatric Anesthesia, 2006
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Forest Systems, Apr 7, 2010
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Bois Et Forets Des Tropiques, 2011
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ABSTRACT Policy Brief. Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ), Bonn, Germany
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Forest Systems
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The world’s temperatures are continuing to increase, forcing long-term strategies for adaptation ... more The world’s temperatures are continuing to increase, forcing long-term strategies for adaptation to climate change. The availability of water is declining and the risk of disasters is increasing. Unsustainable logging and agricultural practices have led to deforestation, resulting in deadly floods and landslides. Forests can not only help mitigate climate change by storing carbon and slowing the rate of temperature increases. Sustainably managed forests and trees on farms can also help soften the blow of climate-induced changes by reducing soil erosion and regulating water flows at the scale of entire landscapes.
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Restoration Ecology, 2015
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Papers by Bruno Locatelli