Papers by Jose Carlos Bernardes
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Boletim da Biblioteca da Universidade de Coimbra, 2015
Sabemos bem que as Bibliotecas nem sempre foram como são hoje. Têm a sua história, ligada a muita... more Sabemos bem que as Bibliotecas nem sempre foram como são hoje. Têm a sua história, ligada a muitas variáveis de circunstância. Tratando-se de uma biblioteca universitária, essa história não pode, desde logo, dissociar-se das condicionantes que pesam na vida da própria universidade.
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Ehumanista Journal of Iberian Studies, 2001
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Gestao Regionalidade, Oct 14, 2009
Page 1. 35 Maria Carolina de Azevedo Ferreira de Souza, Miguel Juan Bacic e José Maria Ramos Bern... more Page 1. 35 Maria Carolina de Azevedo Ferreira de Souza, Miguel Juan Bacic e José Maria Ramos Bernardes Gestão & Regionalidade - Vol. 25 - Nº 74 - mai-ago/2009 A GESTÃO ESTRATÉGICA DAS COMPRAS COMO POLÍTICA ...
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Limite Revista De Estudios Portugueses Y De La Lusofonia, 2013
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O correto aproveitamento dos recursos naturais deve ser feito após criteriosas análises que certi... more O correto aproveitamento dos recursos naturais deve ser feito após criteriosas análises que certifique tal exploração. Este resumo mostra como a análise multivariada justificou a potencialidade do uso de indivíduos de babaçus encontrados em bioma amazônico para fins energéticos.
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Haematologica, 2004
Cytomorphology and IgH/T-cell receptor g clonal gene rearrangements detected by polymerase chain ... more Cytomorphology and IgH/T-cell receptor g clonal gene rearrangements detected by polymerase chain reaction (PCR) homo/heteroduplex analysis and direct sequencing were evaluated in cerebrospinal fluid (CSF) free of red-blood cells at diagnosis of 37 children with acute lymphoblastic leukemia. Molecular CSF involvement was greater as detected by molecular analysis than observed by morphologic criteria (45.9% vs 5.4%). The 4-year event-free survival was lower in the group with molecularly detected CSF involvement (p = 0.01).
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Sao Paulo Medical Journal, 2000
CONTEXT: Mutations of the p53 tumor suppressor gene are the most frequent alterations observed in... more CONTEXT: Mutations of the p53 tumor suppressor gene are the most frequent alterations observed in human neoplasias affecting adults. In pediatric oncology, however, they have seldom been identified. Wilms’ tumor is a renal neoplasia commonly occurring in children and is associated with mutations of the WT1 gene. The correlation between Wilms’ tumor and alterations of the p53 gene has not been well established, with a low frequency of mutations having been reported in this type of tumor. Mutation may be associated with advanced stage disease and unfavorable histology. OBJECTIVE: To screen for mutations of the p53 gene by the PCR-SSCP method and DNA sequencing in cases of Wilms’ tumor sug-gestive of mutation. DESIGN: Case Report. CASE REPORT: Evaluations of exons 5-9 of the p53 gene in DNA samples extracted by PCR-SSCP from 10 Wilms’ tumors in children at different stages, and DNA sequencing. Changes in SSCP analy-sis were observed in exon 8 in two samples. The probable muta-tions wer...
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Revista Española de Cardiología, 2011
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Sao Paulo Medical Journal, 2001
CONTEXT: The CDR-3 region of heavy-chain immunoglobulin has been used as a clonal marker in the s... more CONTEXT: The CDR-3 region of heavy-chain immunoglobulin has been used as a clonal marker in the study of minimal residual disease in children with acute lymphoblastic leukemia. Southern blot and polymerase chain reaction studies have demonstrated the occurrence of bi/oligoclonality in a variable number of cases of B-lineage acute lymphoblastic leukemia, a fact that may strongly interfere with the detection of minimal residual disease. Oligoclonality has also been associated with a poorer prognosis and a higher chance of relapse. OBJECTIVES: To correlate bi/oligoclonality, detected by polymerase chain reaction in Brazilian children with B-lineage acute lymphoblastic leukemia with a chance of relapse, with immunophenotype, risk group, and disease-free survival. DESIGN: Prospective study of patients’ outcome. SETTING: Pediatric Oncology Unit of the University Hospital, Faculty of Medicine of Ribeirão Preto, University of São Paulo. PARTICIPANTS: 47 children with acute lymphoblastic leu...
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Leukemia Research, 2006
Early treatment response assessment has become an import prerequisite in the selection therapy in... more Early treatment response assessment has become an import prerequisite in the selection therapy in childhood ALL. In this study we compare classical diagnostic factors and the significance of three simplified strategies, WBC count at day 7 and a simplified PCR methodology to minimal residual disease detection on days 14 and 28, to evaluate early treatment response in 84 consecutive children with ALL. The use of these simplified methods for the evaluation of early response, proved to be a good predictor of an unfavorable course in children with ALL and could be used as a stratification criterion in treatment protocols, specially in low-budget countries.
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Leukemia Research, 2009
Chronic myeloid leukemia (CML) is a rare disease in childhood which is almost exclusively associa... more Chronic myeloid leukemia (CML) is a rare disease in childhood which is almost exclusively associated with bcr-abl p210 (M-bcr) rearrangements. It has been suggested that co-expression of p190 and p210 may be a pathway of CML progression in adult patients. We report two cases of pediatric patients with a diagnosis of CML who presented co-expression of the p210 and p190 transcripts during progression to the blastic phase. The present data suggest that p190 may be a secondary event in at least some cases of childhood CML, suggesting an association with progression to a blastic crisis in these patients.
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Leukemia Research, 2002
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Journal of Pediatric Hematology/Oncology, 1997
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Cancer Genetics and Cytogenetics, 1996
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Ágora, Sep 26, 2011
Resumo: O estudo aborda a temática do empreendedorismo como um novo modelo de gestão nas unidades... more Resumo: O estudo aborda a temática do empreendedorismo como um novo modelo de gestão nas unidades de informação (arquivos e bibliotecas). O objetivo é debater como o arquivista eo bibliotecário podem ser empreendedores em ambientes da informação: arquivos, bibliotecas, centros de informação e documentação. O trabalho de pesquisa é de natureza exploratória e descritiva. Explora e descreve o fenômeno do empreendedorismo. O resultado visa discutir os conceitos e aplicações do empreendedor no sentido de criar e ...
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Papers by Jose Carlos Bernardes