Obesity correlates with adverse events (AEs) in children with acute myelogenous leukemia and duri... more Obesity correlates with adverse events (AEs) in children with acute myelogenous leukemia and during maintenance therapy for acute lymphoblastic leukemia (ALL). Less is known about AEs in obese ALL patients during pre-maintenance chemotherapy. We evaluated the relationship between obesity (body mass index (BMI) ≥ 95th percentile) and AEs during pre-maintenance chemotherapy in pediatric patients with ALL. One hundred fifty-five pediatric ALL patients diagnosed at a single institution between 2006 and 2012 were retrospectively evaluated for infections, treatment-requiring hypertension, insulin-requiring hyperglycemia, pancreatitis, pediatric intensive care unit admissions, sepsis, febrile neutropenia (FN) admissions, thrombosis, hepatotoxicity, and nephrotoxicity. Univariate and multivariable analyses compared proportions of obese versus nonobese patients experiencing AEs. AEs occurring significantly more frequently in obese patients by univariate analysis included treatment-requiring ...
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2018
Remplissage minimizes recurrence and confers minimal motion loss when applied to glenoid defects ... more Remplissage minimizes recurrence and confers minimal motion loss when applied to glenoid defects up to 20% and humeral loss up to 40% in patients with shoulder instability. However, variability in the reporting of volume of both glenoid and humeral head bone loss deters the formulation of distinct thresholds for indications and contraindication for remplissage. However, there appears to be little downside in the performance of this "biologic" solution to Hill-Sachs lesions.
Instrument detection, pose estimation, and tracking in surgical videos are an important vision co... more Instrument detection, pose estimation, and tracking in surgical videos are an important vision component for computer-assisted interventions. While significant advances have been made in recent years, articulation detection is still a major challenge. In this paper, we propose a deep neural network for articulated multi-instrument 2-D pose estimation, which is trained on detailed annotations of endoscopic and microscopic data sets. Our model is formed by a fully convolutional detection-regression network. Joints and associations between joint pairs in our instrument model are located by the detection subnetwork and are subsequently refined through a regression subnetwork. Based on the output from the model, the poses of the instruments are inferred using maximum bipartite graph matching. Our estimation framework is powered by deep learning techniques without any direct kinematic information from a robot. Our framework is tested on single-instrument RMIT data, and also on multi-instr...
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Jan 14, 2018
Superior capsular reconstruction has received increased attention as a surgical technique to addr... more Superior capsular reconstruction has received increased attention as a surgical technique to address massive 'irreparable' rotator cuff tears; however, the functional limitations and surgical techniques associated with this repair have yet to be sufficiently explored. The goal of this study was to utilize a multidisciplinary approach to characterize the biomechanics of this repair by: 1) identifying activities of daily living that may overburden graft, and 2) optimizing surgical techniques used during implantation. This experiment was completed in three phases. First, graft failure mechanics were characterized by performing an in vitro experiment. Second, in vivo shoulder kinematics associated with various activities were recorded with 3-D motion capture techniques. Finally, an in silico model was used to assess graft strains. Results show that motions involving posterior shoulder rotation, such as back washing, lead to graft strains that may cause failure. Output from the o...
Expert review of gastroenterology & hepatology, Jan 22, 2016
The identification of the top 100 papers in ulcerative colitis (UC) using citation analysis provi... more The identification of the top 100 papers in ulcerative colitis (UC) using citation analysis provides a unique insight into the advancement of disease understanding and subsequent treatment innovations that have progressed over time. The Thomson Reuters Web of Knowledge was used to identify the 100 most cited UC manuscripts. Title, first and senior authors, institution and department of first author, journal, country of origin, year and topic of each manuscript were analyzed. The top 100 manuscripts were published between 1955-2012. Thirty eight percent of the manuscripts originated from the US followed by the UK (26%). Genetics was the topic with the most publications (n = 27), followed by treatment (n = 22) and immunological pathways (n = 17). Truelove had the highest amount of authorships. The institutions with the highest number of publications were St. Mark's, London and the Radcliffe Infirmary. This list of highly cited papers identifies the topics and authors that have mad...
Religion and spirituality influence how many patients and families experience illness, but knowle... more Religion and spirituality influence how many patients and families experience illness, but knowledge of the level of spiritual care provided to caregivers of pediatric patients within the hospital is limited. We evaluated patient caregivers' perceptions of the extent to which their religious and spiritual (R/S) needs were assessed and addressed in the hospital. We surveyed primary caregivers of children referred to palliative care <1 year prior at an urban, pediatric academic medical center. Participants completed a structured questionnaire with quantitative and qualitative measures of the provision of spiritual care in the hospital. Nonparametric tests were used to compare various measures of perceived and desired R/S support. The majority (16/24) of caregivers desired inquiry about R/S needs by the medical team. Fewer than half (12/25) had these needs assessed. No subjects were uncomfortable with questions regarding R/S needs. Only 35% (8/23) specifically wanted a physician...
International journal of computer assisted radiology and surgery, Jan 2, 2016
Computer-assisted interventions for enhanced minimally invasive surgery (MIS) require tracking of... more Computer-assisted interventions for enhanced minimally invasive surgery (MIS) require tracking of the surgical instruments. Instrument tracking is a challenging problem in both conventional and robotic-assisted MIS, but vision-based approaches are a promising solution with minimal hardware integration requirements. However, vision-based methods suffer from drift, and in the case of occlusions, shadows and fast motion, they can be subject to complete tracking failure. In this paper, we develop a 2D tracker based on a Generalized Hough Transform using SIFT features which can both handle complex environmental changes and recover from tracking failure. We use this to initialize a 3D tracker at each frame which enables us to recover 3D instrument pose over long sequences and even during occlusions. We quantitatively validate our method in 2D and 3D with ex vivo data collected from a DVRK controller as well as providing qualitative validation on robotic-assisted in vivo data. We demonstra...
Industrial relations systems have long been classified into different groups, such as the Anglo-S... more Industrial relations systems have long been classified into different groups, such as the Anglo-Saxon, the Scandinavian, or the continental European model. Similarly, welfare states have also been sorted into several categories, such as Christian-democratic, liberal, or social-democratic. The Varieties of Capitalism (VoC) approach has grouped capitalist systems–especially those of the OECD–into several categories, such as Liberal Market Economies (LMEs) and Coordinated Market Economies (CMEs). Given the parallel ...
Obesity correlates with adverse events (AEs) in children with acute myelogenous leukemia and duri... more Obesity correlates with adverse events (AEs) in children with acute myelogenous leukemia and during maintenance therapy for acute lymphoblastic leukemia (ALL). Less is known about AEs in obese ALL patients during pre-maintenance chemotherapy. We evaluated the relationship between obesity (body mass index (BMI) ≥ 95th percentile) and AEs during pre-maintenance chemotherapy in pediatric patients with ALL. One hundred fifty-five pediatric ALL patients diagnosed at a single institution between 2006 and 2012 were retrospectively evaluated for infections, treatment-requiring hypertension, insulin-requiring hyperglycemia, pancreatitis, pediatric intensive care unit admissions, sepsis, febrile neutropenia (FN) admissions, thrombosis, hepatotoxicity, and nephrotoxicity. Univariate and multivariable analyses compared proportions of obese versus nonobese patients experiencing AEs. AEs occurring significantly more frequently in obese patients by univariate analysis included treatment-requiring ...
Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2018
Remplissage minimizes recurrence and confers minimal motion loss when applied to glenoid defects ... more Remplissage minimizes recurrence and confers minimal motion loss when applied to glenoid defects up to 20% and humeral loss up to 40% in patients with shoulder instability. However, variability in the reporting of volume of both glenoid and humeral head bone loss deters the formulation of distinct thresholds for indications and contraindication for remplissage. However, there appears to be little downside in the performance of this "biologic" solution to Hill-Sachs lesions.
Instrument detection, pose estimation, and tracking in surgical videos are an important vision co... more Instrument detection, pose estimation, and tracking in surgical videos are an important vision component for computer-assisted interventions. While significant advances have been made in recent years, articulation detection is still a major challenge. In this paper, we propose a deep neural network for articulated multi-instrument 2-D pose estimation, which is trained on detailed annotations of endoscopic and microscopic data sets. Our model is formed by a fully convolutional detection-regression network. Joints and associations between joint pairs in our instrument model are located by the detection subnetwork and are subsequently refined through a regression subnetwork. Based on the output from the model, the poses of the instruments are inferred using maximum bipartite graph matching. Our estimation framework is powered by deep learning techniques without any direct kinematic information from a robot. Our framework is tested on single-instrument RMIT data, and also on multi-instr...
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Jan 14, 2018
Superior capsular reconstruction has received increased attention as a surgical technique to addr... more Superior capsular reconstruction has received increased attention as a surgical technique to address massive 'irreparable' rotator cuff tears; however, the functional limitations and surgical techniques associated with this repair have yet to be sufficiently explored. The goal of this study was to utilize a multidisciplinary approach to characterize the biomechanics of this repair by: 1) identifying activities of daily living that may overburden graft, and 2) optimizing surgical techniques used during implantation. This experiment was completed in three phases. First, graft failure mechanics were characterized by performing an in vitro experiment. Second, in vivo shoulder kinematics associated with various activities were recorded with 3-D motion capture techniques. Finally, an in silico model was used to assess graft strains. Results show that motions involving posterior shoulder rotation, such as back washing, lead to graft strains that may cause failure. Output from the o...
Expert review of gastroenterology & hepatology, Jan 22, 2016
The identification of the top 100 papers in ulcerative colitis (UC) using citation analysis provi... more The identification of the top 100 papers in ulcerative colitis (UC) using citation analysis provides a unique insight into the advancement of disease understanding and subsequent treatment innovations that have progressed over time. The Thomson Reuters Web of Knowledge was used to identify the 100 most cited UC manuscripts. Title, first and senior authors, institution and department of first author, journal, country of origin, year and topic of each manuscript were analyzed. The top 100 manuscripts were published between 1955-2012. Thirty eight percent of the manuscripts originated from the US followed by the UK (26%). Genetics was the topic with the most publications (n = 27), followed by treatment (n = 22) and immunological pathways (n = 17). Truelove had the highest amount of authorships. The institutions with the highest number of publications were St. Mark's, London and the Radcliffe Infirmary. This list of highly cited papers identifies the topics and authors that have mad...
Religion and spirituality influence how many patients and families experience illness, but knowle... more Religion and spirituality influence how many patients and families experience illness, but knowledge of the level of spiritual care provided to caregivers of pediatric patients within the hospital is limited. We evaluated patient caregivers' perceptions of the extent to which their religious and spiritual (R/S) needs were assessed and addressed in the hospital. We surveyed primary caregivers of children referred to palliative care <1 year prior at an urban, pediatric academic medical center. Participants completed a structured questionnaire with quantitative and qualitative measures of the provision of spiritual care in the hospital. Nonparametric tests were used to compare various measures of perceived and desired R/S support. The majority (16/24) of caregivers desired inquiry about R/S needs by the medical team. Fewer than half (12/25) had these needs assessed. No subjects were uncomfortable with questions regarding R/S needs. Only 35% (8/23) specifically wanted a physician...
International journal of computer assisted radiology and surgery, Jan 2, 2016
Computer-assisted interventions for enhanced minimally invasive surgery (MIS) require tracking of... more Computer-assisted interventions for enhanced minimally invasive surgery (MIS) require tracking of the surgical instruments. Instrument tracking is a challenging problem in both conventional and robotic-assisted MIS, but vision-based approaches are a promising solution with minimal hardware integration requirements. However, vision-based methods suffer from drift, and in the case of occlusions, shadows and fast motion, they can be subject to complete tracking failure. In this paper, we develop a 2D tracker based on a Generalized Hough Transform using SIFT features which can both handle complex environmental changes and recover from tracking failure. We use this to initialize a 3D tracker at each frame which enables us to recover 3D instrument pose over long sequences and even during occlusions. We quantitatively validate our method in 2D and 3D with ex vivo data collected from a DVRK controller as well as providing qualitative validation on robotic-assisted in vivo data. We demonstra...
Industrial relations systems have long been classified into different groups, such as the Anglo-S... more Industrial relations systems have long been classified into different groups, such as the Anglo-Saxon, the Scandinavian, or the continental European model. Similarly, welfare states have also been sorted into several categories, such as Christian-democratic, liberal, or social-democratic. The Varieties of Capitalism (VoC) approach has grouped capitalist systems–especially those of the OECD–into several categories, such as Liberal Market Economies (LMEs) and Coordinated Market Economies (CMEs). Given the parallel ...
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Papers by John Kelly